THRAP3 — 119 ClinVar variants
All ClinVar germline THRAP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →
5 Likely benign · 114 Uncertain significance
Full THRAP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 113
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 88
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- THRAP3 p.Ala117Ser Uncertain significance Single submitter
- THRAP3 p.Ala236Val Uncertain significance Single submitter
- THRAP3 p.Ala291Val Uncertain significance Single submitter
- THRAP3 p.Ala581Thr Uncertain significance Single submitter
- THRAP3 p.Arg153Gln Uncertain significance Single submitter
- THRAP3 p.Arg156His Uncertain significance Single submitter
- THRAP3 p.Arg15His Uncertain significance Single submitter
- THRAP3 p.Arg235Trp Uncertain significance Single submitter
- THRAP3 p.Arg245Gly Uncertain significance Single submitter
- THRAP3 p.Arg266Cys Uncertain significance Single submitter
- THRAP3 p.Arg39His Uncertain significance Single submitter
- THRAP3 p.Arg39Pro Uncertain significance Single submitter
- THRAP3 p.Arg504Gln Uncertain significance Single submitter
- THRAP3 p.Arg504Gly Uncertain significance Single submitter
- THRAP3 p.Arg545Gln Uncertain significance Single submitter
- THRAP3 p.Arg595Gln Uncertain significance Single submitter
- THRAP3 p.Arg687Lys Uncertain significance Single submitter
- THRAP3 p.Arg700Gln Uncertain significance Single submitter
- THRAP3 p.Arg718Cys Uncertain significance Single submitter
- THRAP3 p.Arg802Thr Uncertain significance Single submitter
- THRAP3 p.Arg865Gln Uncertain significance Single submitter
- THRAP3 p.Arg87His Uncertain significance Single submitter
- THRAP3 p.Arg944Pro Uncertain significance Single submitter
- THRAP3 p.Asn460Lys Uncertain significance Single submitter
- THRAP3 p.Asn852Ser Uncertain significance Single submitter
- THRAP3 p.Asn853Ser Uncertain significance Single submitter
- THRAP3 p.Asn949Ser Uncertain significance Single submitter
- THRAP3 p.Asp303Asn Uncertain significance Single submitter
- THRAP3 p.Asp368Asn Uncertain significance Single submitter
- THRAP3 p.Asp416Asn Uncertain significance Single submitter
- THRAP3 p.Asp431Gly Uncertain significance Single submitter
- THRAP3 p.Asp546Asn Uncertain significance Single submitter
- THRAP3 p.Asp818Glu Uncertain significance Single submitter
- THRAP3 p.Asp948Ala Uncertain significance Single submitter
- THRAP3 p.Gln294His Uncertain significance Single submitter
- THRAP3 p.Gln407Arg Uncertain significance Single submitter
- THRAP3 p.Gln861Arg Uncertain significance Single submitter
- THRAP3 p.Gln861Pro Uncertain significance Single submitter
- THRAP3 p.Glu170Gln Uncertain significance Single submitter
- THRAP3 p.Glu203Lys Uncertain significance Single submitter
- THRAP3 p.Glu241Gly Uncertain significance Single submitter
- THRAP3 p.Gly194Arg Uncertain significance Single submitter
- THRAP3 p.Gly514Val Uncertain significance Single submitter
- THRAP3 p.Gly549Glu Uncertain significance Single submitter
- THRAP3 p.Gly826Glu Uncertain significance Single submitter
- THRAP3 p.Gly844Val Uncertain significance Single submitter
- THRAP3 p.Gly888Val Uncertain significance Single submitter
- THRAP3 p.His304Arg Uncertain significance Single submitter
- THRAP3 p.His693Leu Uncertain significance Single submitter
- THRAP3 p.His761Asn Uncertain significance Single submitter
- THRAP3 p.Ile950Met Uncertain significance Single submitter
- THRAP3 p.Leu242Pro Uncertain significance Single submitter
- THRAP3 p.Leu349Pro Uncertain significance Single submitter
- THRAP3 p.Lys252Arg Uncertain significance Single submitter
- THRAP3 p.Lys333Glu Uncertain significance Single submitter
- THRAP3 p.Lys360Glu Uncertain significance Single submitter
- THRAP3 p.Lys396Arg Uncertain significance Single submitter
- THRAP3 p.Lys401Asn Uncertain significance Single submitter
- THRAP3 p.Lys437Glu Uncertain significance Single submitter
- THRAP3 p.Lys439Glu Uncertain significance Single submitter
- THRAP3 p.Lys451Arg Uncertain significance Single submitter
- THRAP3 p.Lys668Arg Uncertain significance Single submitter
- THRAP3 p.Lys921Arg Uncertain significance Single submitter
- THRAP3 p.Met422Thr Uncertain significance Single submitter
- THRAP3 p.Met422Val Uncertain significance Single submitter
- THRAP3 p.Met453Ile Uncertain significance Single submitter
- THRAP3 p.Pro267Leu Uncertain significance Single submitter
- THRAP3 p.Pro702Leu Uncertain significance Single submitter
- THRAP3 p.Pro952Ser Uncertain significance Single submitter
- THRAP3 p.Ser278Cys Uncertain significance Single submitter
- THRAP3 p.Ser278Tyr Uncertain significance Single submitter
- THRAP3 p.Ser320Thr Uncertain significance Single submitter
- THRAP3 p.Ser336Arg Uncertain significance Single submitter
- THRAP3 p.Ser499Thr Uncertain significance Single submitter
- THRAP3 p.Ser747Gly Uncertain significance Single submitter
- THRAP3 p.Ser747Thr Uncertain significance Single submitter
- THRAP3 p.Ser787Pro Uncertain significance Single submitter
- THRAP3 p.Ser823Cys Uncertain significance Single submitter
- THRAP3 p.Ser939Thr Uncertain significance Single submitter
- THRAP3 p.Thr210Ile Uncertain significance Single submitter
- THRAP3 p.Thr297Ile Uncertain significance Single submitter
- THRAP3 p.Thr556Ala Uncertain significance Single submitter
- THRAP3 p.Thr556Ile Uncertain significance Single submitter
- THRAP3 p.Thr799Ala Uncertain significance Single submitter
- THRAP3 p.Thr807Met Uncertain significance Single submitter
- THRAP3 p.Tyr228Cys Uncertain significance Single submitter
- THRAP3 p.Tyr293His Uncertain significance Single submitter
- THRAP3 p.Tyr476Cys Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- THRAP3 p.Arg15Cys Uncertain significance Single submitter
- THRAP3 p.Arg174Cys Uncertain significance Single submitter
- THRAP3 p.Arg245Trp Uncertain significance Single submitter
- THRAP3 p.Arg35Gln Uncertain significance Single submitter
- THRAP3 p.Arg608Cys Uncertain significance Single submitter
- THRAP3 p.Arg837Gly Uncertain significance Single submitter
- THRAP3 p.Arg906Trp Uncertain significance Single submitter
- THRAP3 p.Arg914Gln Uncertain significance Single submitter
- THRAP3 p.Asp818His Uncertain significance Single submitter
- THRAP3 p.Gln112Arg Uncertain significance Single submitter
- THRAP3 p.Glu482Lys Uncertain significance Single submitter
- THRAP3 p.Gly514Asp Uncertain significance Single submitter
- THRAP3 p.Gly644Glu Uncertain significance Single submitter
- THRAP3 p.Lys519Asn Uncertain significance Single submitter
- THRAP3 p.Phe73Ile Uncertain significance Single submitter
- THRAP3 p.Pro95Leu Uncertain significance Single submitter
- THRAP3 p.Ser310Arg Uncertain significance Single submitter
- THRAP3 p.Ser737Leu Uncertain significance Single submitter
- THRAP3 p.Ser753Leu Uncertain significance Single submitter
- THRAP3 p.Ser779Phe Uncertain significance Single submitter
- THRAP3 p.Thr874Ala Uncertain significance Single submitter
- THRAP3 p.Tyr104Cys Uncertain significance Single submitter
- THRAP3 p.Tyr84Cys Uncertain significance Single submitter
- THRAP3 p.Val260Leu Uncertain significance Single submitter
- THRAP3 p.Val598Asp Uncertain significance Single submitter
All THRAP3 variants
Likely benign 5
- c.2647-17A>G Multiple submitters
- p.Arg347= Single submitter
- p.Asn858= Single submitter
- p.Ser295Ala Single submitter
- p.Thr954Ala Single submitter
Uncertain significance 114
- p.Ala117Ser Single submitter ⚠
- p.Ala236Val Single submitter ⚠
- p.Ala291Val Single submitter ⚠
- p.Ala581Thr Single submitter ⚠
- p.Arg153Gln Single submitter ⚠
- p.Arg156His Single submitter ⚠
- p.Arg15Cys Single submitter ⚠
- p.Arg15His Single submitter ⚠
- p.Arg174Cys Single submitter ⚠
- p.Arg235Trp Single submitter ⚠
- p.Arg245Gly Single submitter ⚠
- p.Arg245Trp Single submitter ⚠
- p.Arg266Cys Single submitter ⚠
- p.Arg35Gln Single submitter ⚠
- p.Arg39His Single submitter ⚠
- p.Arg39Pro Single submitter ⚠
- p.Arg504Gln Single submitter ⚠
- p.Arg504Gly Single submitter ⚠
- p.Arg545Gln Single submitter ⚠
- p.Arg595Gln Single submitter ⚠
- p.Arg608Cys Single submitter ⚠
- p.Arg687Lys Single submitter ⚠
- p.Arg700Gln Single submitter ⚠
- p.Arg718Cys Single submitter ⚠
- p.Arg802Thr Single submitter ⚠
- p.Arg837Gly Single submitter ⚠
- p.Arg865Gln Single submitter ⚠
- p.Arg87His Single submitter ⚠
- p.Arg906Trp Single submitter ⚠
- p.Arg914Gln Single submitter ⚠
- p.Arg944Pro Single submitter ⚠
- p.Asn460Lys Single submitter ⚠
- p.Asn462fs Single submitter
- p.Asn852Ser Single submitter ⚠
- p.Asn853Ser Single submitter ⚠
- p.Asn949Ser Single submitter ⚠
- p.Asp303Asn Single submitter ⚠
- p.Asp368Asn Single submitter ⚠
- p.Asp416Asn Single submitter ⚠
- p.Asp431Gly Single submitter ⚠
- p.Asp546Asn Single submitter ⚠
- p.Asp818Glu Single submitter ⚠
- p.Asp818His Single submitter ⚠
- p.Asp948Ala Single submitter ⚠
- p.Gln112Arg Single submitter ⚠
- p.Gln294His Single submitter ⚠
- p.Gln407Arg Single submitter ⚠
- p.Gln861Arg Single submitter ⚠
- p.Gln861Pro Single submitter ⚠
- p.Glu170Gln Single submitter ⚠
- p.Glu203Lys Single submitter ⚠
- p.Glu241Gly Single submitter ⚠
- p.Glu482Lys Single submitter ⚠
- p.Gly194Arg Single submitter ⚠
- p.Gly514Asp Single submitter ⚠
- p.Gly514Val Single submitter ⚠
- p.Gly549Glu Single submitter ⚠
- p.Gly644Glu Single submitter ⚠
- p.Gly826Glu Single submitter ⚠
- p.Gly844Val Single submitter ⚠
- p.Gly888Val Single submitter ⚠
- p.His304Arg Single submitter ⚠
- p.His693Leu Single submitter ⚠
- p.His761Asn Single submitter ⚠
- p.Ile950Met Single submitter ⚠
- p.Leu242Pro Single submitter ⚠
- p.Leu349Pro Single submitter ⚠
- p.Lys252Arg Single submitter ⚠
- p.Lys333Glu Single submitter ⚠
- p.Lys360Glu Single submitter ⚠
- p.Lys396Arg Single submitter ⚠
- p.Lys401Asn Single submitter ⚠
- p.Lys437Glu Single submitter ⚠
- p.Lys439Glu Single submitter ⚠
- p.Lys451Arg Single submitter ⚠
- p.Lys519Asn Single submitter ⚠
- p.Lys668Arg Single submitter ⚠
- p.Lys921Arg Single submitter ⚠
- p.Met422Thr Single submitter ⚠
- p.Met422Val Single submitter ⚠
- p.Met453Ile Single submitter ⚠
- p.Phe73Ile Single submitter ⚠
- p.Pro267Leu Single submitter ⚠
- p.Pro702Leu Single submitter ⚠
- p.Pro952Ser Single submitter ⚠
- p.Pro95Leu Single submitter ⚠
- p.Ser278Cys Single submitter ⚠
- p.Ser278Tyr Single submitter ⚠
- p.Ser310Arg Single submitter ⚠
- p.Ser320Thr Single submitter ⚠
- p.Ser336Arg Single submitter ⚠
- p.Ser499Thr Single submitter ⚠
- p.Ser737Leu Single submitter ⚠
- p.Ser747Gly Single submitter ⚠
- p.Ser747Thr Single submitter ⚠
- p.Ser753Leu Single submitter ⚠
- p.Ser779Phe Single submitter ⚠
- p.Ser787Pro Single submitter ⚠
- p.Ser823Cys Single submitter ⚠
- p.Ser939Thr Single submitter ⚠
- p.Thr210Ile Single submitter ⚠
- p.Thr297Ile Single submitter ⚠
- p.Thr556Ala Single submitter ⚠
- p.Thr556Ile Single submitter ⚠
- p.Thr799Ala Single submitter ⚠
- p.Thr807Met Single submitter ⚠
- p.Thr874Ala Single submitter ⚠
- p.Tyr104Cys Single submitter ⚠
- p.Tyr228Cys Single submitter ⚠
- p.Tyr293His Single submitter ⚠
- p.Tyr476Cys Single submitter ⚠
- p.Tyr84Cys Single submitter ⚠
- p.Val260Leu Single submitter ⚠
- p.Val598Asp Single submitter ⚠