TIAL1 — 17 ClinVar variants
All ClinVar germline TIAL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
17 Uncertain significance
Full TIAL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TIAL1 p.Ala213Ser Uncertain significance Single submitter
- TIAL1 p.Arg192Ser Uncertain significance Single submitter
- TIAL1 p.Gly343Ala Uncertain significance Single submitter
- TIAL1 p.Met132Val Uncertain significance Single submitter
- TIAL1 p.Met281Thr Uncertain significance Single submitter
- TIAL1 p.Met281Val Uncertain significance Single submitter
- TIAL1 p.Pro337Ser Uncertain significance Single submitter
- TIAL1 p.Pro356Ser Uncertain significance Single submitter
- TIAL1 p.Ser259Ala Uncertain significance Single submitter
- TIAL1 p.Thr188Ile Uncertain significance Single submitter
- TIAL1 p.Thr264Met Uncertain significance Single submitter
- TIAL1 p.Val13Ile Uncertain significance Single submitter
- TIAL1 p.Val269Ala Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All TIAL1 variants
Uncertain significance 17
- c.130-48C>T Single submitter
- p.Ala213Ser Single submitter ⚠
- p.Arg192Ser Single submitter ⚠
- p.Gly343Ala Single submitter ⚠
- p.Met132Val Single submitter ⚠
- p.Met281Thr Single submitter ⚠
- p.Met281Val Single submitter ⚠
- p.Pro337Ser Single submitter ⚠
- p.Pro356Ser Single submitter ⚠
- p.Ser259Ala Single submitter ⚠
- p.Ser278Cys Single submitter ⚠
- p.Ser291Arg Single submitter ⚠
- p.Thr188Ile Single submitter ⚠
- p.Thr264Met Single submitter ⚠
- p.Thr84Ala Single submitter
- p.Val13Ile Single submitter ⚠
- p.Val269Ala Single submitter ⚠