TIMELESS — 192 ClinVar variants

All ClinVar germline TIMELESS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 156 flagged for review →

1 Pathogenic · 1 Conflicting · 4 Benign · 3 Benign/Likely benign · 20 Likely benign · 163 Uncertain significance

Full TIMELESS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 156

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

TIMELESS p.Asp839Asn Conflicting Single submitter
advance sleep phase syndrome, familial, 4

Predictors lean, ClinVar uncertain 119

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 36

The independent predictors disagree with each other — read with care.

All TIMELESS variants

Pathogenic 1

p.Arg1081Ter No assertion criteria advance sleep phase syndrome, familial, 4

Conflicting classifications of pathogenicity 1

p.Asp839Asn Single submitter advance sleep phase syndrome, familial, 4 ⚠

Benign 4

p.Met578Val Multiple submitters
p.Phe1060Leu Multiple submitters
p.Phe509= Multiple submitters
p.Val910Ile Single submitter

Benign/Likely benign 3

p.Ala1145= Multiple submitters
p.Ala129Ser Multiple submitters
p.Arg905Trp Multiple submitters ⚠

Likely benign 20

c.1868+8C>T Single submitter
c.2524+3G>A Single submitter
c.3040+6G>A Single submitter
c.687+14C>G Single submitter
p.Ala1131= Single submitter
p.Ala1155Thr Single submitter
p.Arg395Gln Single submitter
p.Arg813= Single submitter
p.Cys517Tyr Single submitter
p.Gln880= Single submitter
p.Gly1193Glu Single submitter
p.Gly808= Single submitter
p.Gly891Glu Single submitter
p.Leu173Phe Single submitter
p.Leu835= Single submitter
p.Lys1114Glu Single submitter
p.Pro1150= Single submitter
p.Pro1160= Single submitter
p.Ser208= Single submitter
p.Ser63= Single submitter

Uncertain significance 163

p.Asn337Ser Multiple submitters ⚠
c.909+5G>A Single submitter advance sleep phase syndrome, familial, 4
p.Ala1041Gly Single submitter ⚠
p.Ala1041Thr Single submitter ⚠
p.Ala1133Pro Single submitter ⚠
p.Ala1145Val Single submitter ⚠
p.Ala1148Thr Single submitter ⚠
p.Ala1155Asp Single submitter ⚠
p.Ala16Thr Single submitter
p.Ala183Ser Single submitter ⚠
p.Ala235Glu Single submitter ⚠
p.Ala235Val Single submitter ⚠
p.Ala335Asp Single submitter ⚠
p.Ala370Ser Single submitter ⚠
p.Ala429Thr Single submitter ⚠
p.Ala586Val Single submitter ⚠
p.Ala760Gly Single submitter ⚠
p.Ala782Ser Single submitter ⚠
p.Ala836Thr Single submitter ⚠
p.Ala925Thr Single submitter ⚠
p.Arg1033Trp Single submitter ⚠
p.Arg1065His Single submitter ⚠
p.Arg1070Gln Single submitter ⚠
p.Arg1081Gln Single submitter ⚠
p.Arg1092Gln Single submitter ⚠
p.Arg1092Trp Single submitter ⚠
p.Arg1130Gln Single submitter ⚠
p.Arg1183Gly Single submitter ⚠
p.Arg227His Single submitter ⚠
p.Arg241Cys Single submitter ⚠
p.Arg241His Single submitter ⚠
p.Arg246Gln Single submitter ⚠
p.Arg246Gly Single submitter ⚠
p.Arg257Cys Single submitter ⚠
p.Arg259Gln Single submitter ⚠
p.Arg267Gln Single submitter ⚠
p.Arg271Gln Single submitter ⚠
p.Arg321His Single submitter ⚠
p.Arg322Cys Single submitter ⚠
p.Arg333Cys Single submitter ⚠
p.Arg356Gln Single submitter ⚠
p.Arg390Gly Single submitter ⚠
p.Arg426His Single submitter ⚠
p.Arg426Leu Single submitter ⚠
p.Arg435Trp Single submitter ⚠
p.Arg466Gly Single submitter ⚠
p.Arg466His Single submitter ⚠
p.Arg479Gln Single submitter
p.Arg492Gly Single submitter ⚠
p.Arg496Cys Single submitter ⚠
p.Arg496His Single submitter ⚠
p.Arg500His Single submitter ⚠
p.Arg520Cys Single submitter ⚠
p.Arg520Leu Single submitter ⚠
p.Arg52Trp Single submitter ⚠
p.Arg596Gln Single submitter ⚠
p.Arg596Trp Single submitter ⚠
p.Arg602Gln Single submitter ⚠
p.Arg731Trp Single submitter ⚠
p.Arg753Cys Single submitter ⚠
p.Arg753His Single submitter ⚠
p.Arg817His Single submitter ⚠
p.Arg860His Single submitter ⚠
p.Arg922Cys Single submitter
p.Arg922His Single submitter
p.Arg924Gln Single submitter ⚠
p.Arg940Gln Single submitter ⚠
p.Arg940Trp Single submitter
p.Arg941Gln Single submitter ⚠
p.Arg947Gln Single submitter ⚠
p.Arg947Trp Single submitter ⚠
p.Asn1003Asp Single submitter ⚠
p.Asn1051Asp Single submitter ⚠
p.Asn337Ile Single submitter
p.Asn471Lys Single submitter ⚠
p.Asn837Asp Single submitter ⚠
p.Asp1172Asn Single submitter ⚠
p.Asp1174Asn Single submitter ⚠
p.Asp1205Val Single submitter ⚠
p.Asp1208His Single submitter ⚠
p.Asp37Tyr Single submitter ⚠
p.Asp425Gly Single submitter ⚠
p.Asp46Asn Single submitter ⚠
p.Asp735Gly Single submitter ⚠
p.Asp892Gly Single submitter ⚠
p.Gln1108His Single submitter ⚠
p.Gln233Lys Single submitter ⚠
p.Gln285Arg Single submitter ⚠
p.Gln494Pro Single submitter ⚠
p.Glu1049Lys Single submitter ⚠
p.Glu1058Lys Single submitter ⚠
p.Glu1159Gln Single submitter ⚠
p.Glu232Lys Single submitter ⚠
p.Glu477Asp Single submitter ⚠
p.Glu594Lys Single submitter ⚠
p.Gly144Asp Single submitter ⚠
p.Gly197Ser Single submitter ⚠
p.Gly291Arg Single submitter ⚠
p.Gly883Glu Single submitter ⚠
p.Gly988Ala Single submitter ⚠
p.His1125Arg Single submitter ⚠
p.His168Tyr Single submitter ⚠
p.His72Tyr Single submitter ⚠
p.His734Arg Single submitter ⚠
p.His913Arg Single submitter ⚠
p.Ile1017Val Single submitter ⚠
p.Ile330Leu Single submitter ⚠
p.Ile468Phe Single submitter ⚠
p.Ile472Val Single submitter ⚠
p.Leu1107Val Single submitter ⚠
p.Leu1171Val Single submitter ⚠
p.Leu1189Val Single submitter ⚠
p.Leu485Phe Single submitter
p.Leu508Val Single submitter ⚠
p.Leu607Pro Single submitter ⚠
p.Leu956Trp Single submitter ⚠
p.Leu95Phe Single submitter
p.Lys1066Arg Single submitter ⚠
p.Lys1127Glu Single submitter ⚠
p.Lys1167Thr Single submitter ⚠
p.Lys369Asn Single submitter ⚠
p.Lys737Arg Single submitter ⚠
p.Met261Leu Single submitter ⚠
p.Met358Val Single submitter ⚠
p.Met578Thr Single submitter ⚠
p.Met5Val Single submitter ⚠
p.Met600Ile Single submitter ⚠
p.Met803Ile Single submitter ⚠
p.Met915Val Single submitter ⚠
p.Phe278Ser Single submitter ⚠
p.Phe388Ser Single submitter ⚠
p.Phe486Leu Single submitter ⚠
p.Phe498Leu Single submitter ⚠
p.Phe769Leu Single submitter ⚠
p.Phe904Leu Single submitter ⚠
p.Pro1043Ala Single submitter ⚠
p.Pro1088Ser Single submitter ⚠
p.Pro1116Leu Single submitter ⚠
p.Pro1160Leu Single submitter ⚠
p.Pro613Ala Single submitter ⚠
p.Pro957Leu Single submitter ⚠
p.Pro978His Single submitter ⚠
p.Ser1039Thr Single submitter ⚠
p.Ser15Arg Single submitter ⚠
p.Ser207Thr Single submitter ⚠
p.Ser329Phe Single submitter ⚠
p.Ser360Leu Single submitter ⚠
p.Ser551Phe Single submitter ⚠
p.Ser552Asn Single submitter ⚠
p.Ser574Phe Single submitter ⚠
p.Thr1089Ala Single submitter ⚠
p.Thr136Asn Single submitter ⚠
p.Thr402Ser Single submitter ⚠
p.Thr506Ala Single submitter ⚠
p.Thr617Ser Single submitter ⚠
p.Tyr419Cys Single submitter ⚠
p.Tyr41Asn Single submitter ⚠
p.Tyr807Cys Single submitter ⚠
p.Val1042Ile Single submitter ⚠
p.Val399Ile Single submitter ⚠
p.Val592Met Single submitter ⚠
p.Val767Leu Single submitter ⚠
p.Val856Gly Single submitter ⚠