TIPARP — 70 ClinVar variants
All ClinVar germline TIPARP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
2 Benign · 2 Likely benign · 66 Uncertain significance
Full TIPARP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TIPARP p.Ala124Val Uncertain significance Single submitter
- TIPARP p.Arg133Leu Uncertain significance Single submitter
- TIPARP p.Arg272Gly Uncertain significance Single submitter
- TIPARP p.Arg28Lys Uncertain significance Single submitter
- TIPARP p.Arg366Gln Uncertain significance Single submitter
- TIPARP p.Arg374Trp Uncertain significance Single submitter
- TIPARP p.Arg396Lys Uncertain significance Single submitter
- TIPARP p.Arg406His Uncertain significance Single submitter
- TIPARP p.Arg521His Uncertain significance Single submitter
- TIPARP p.Asn283Ser Uncertain significance Single submitter
- TIPARP p.Asn340Tyr Uncertain significance Single submitter
- TIPARP p.Asn447His Uncertain significance Single submitter
- TIPARP p.Asn97Ser Uncertain significance Single submitter
- TIPARP p.Asp113Glu Uncertain significance Single submitter
- TIPARP p.Asp119Asn Uncertain significance Single submitter
- TIPARP p.Asp119His Uncertain significance Single submitter
- TIPARP p.Asp176Glu Uncertain significance Single submitter
- TIPARP p.Asp213Asn Uncertain significance Single submitter
- TIPARP p.Asp21Gly Uncertain significance Single submitter
- TIPARP p.Gln327His Uncertain significance Single submitter
- TIPARP p.Gln501Pro Uncertain significance Single submitter
- TIPARP p.Glu31Gln Uncertain significance Single submitter
- TIPARP p.Gly602Ser Uncertain significance Single submitter
- TIPARP p.His158Arg Uncertain significance Single submitter
- TIPARP p.His387Gln Uncertain significance Single submitter
- TIPARP p.His601Tyr Uncertain significance Single submitter
- TIPARP p.Ile199Thr Uncertain significance Single submitter
- TIPARP p.Ile33Met Uncertain significance Single submitter
- TIPARP p.Ile399Arg Uncertain significance Single submitter
- TIPARP p.Leu163Val Uncertain significance Single submitter
- TIPARP p.Leu592Pro Uncertain significance Single submitter
- TIPARP p.Leu60Ile Uncertain significance Single submitter
- TIPARP p.Lys180Arg Uncertain significance Single submitter
- TIPARP p.Lys304Asn Uncertain significance Single submitter
- TIPARP p.Lys511Asn Uncertain significance Single submitter
- TIPARP p.Met107Val Uncertain significance Single submitter
- TIPARP p.Met598Leu Uncertain significance Single submitter
- TIPARP p.Met598Thr Uncertain significance Single submitter
- TIPARP p.Met89Val Uncertain significance Single submitter
- TIPARP p.Pro126Ser Uncertain significance Single submitter
- TIPARP p.Pro136Ala Uncertain significance Single submitter
- TIPARP p.Pro136Arg Uncertain significance Single submitter
- TIPARP p.Pro136Ser Uncertain significance Single submitter
- TIPARP p.Pro156Leu Uncertain significance Single submitter
- TIPARP p.Pro428Ser Uncertain significance Single submitter
- TIPARP p.Ser656Pro Uncertain significance Single submitter
- TIPARP p.Ser656Thr Uncertain significance Single submitter
- TIPARP p.Thr323Ala Uncertain significance Single submitter
- TIPARP p.Thr6Ser Uncertain significance Single submitter
- TIPARP p.Tyr305Cys Uncertain significance Single submitter
- TIPARP p.Val346Leu Uncertain significance Single submitter
- TIPARP p.Val583Ile Uncertain significance Single submitter
- TIPARP p.Val623Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- TIPARP p.Asp353Val Uncertain significance Single submitter
- TIPARP p.Glu225Gln Uncertain significance Single submitter
- TIPARP p.Glu378Lys Uncertain significance Single submitter
- TIPARP p.Glu505Lys Uncertain significance Single submitter
- TIPARP p.Leu618Phe Uncertain significance Single submitter
- TIPARP p.Lys506Arg Uncertain significance Single submitter
- TIPARP p.Met383Ile Uncertain significance Single submitter
- TIPARP p.Phe325Ser Uncertain significance Single submitter
- TIPARP p.Thr557Ala Uncertain significance Single submitter
- TIPARP p.Tyr643Ser Uncertain significance Single submitter
All TIPARP variants
Benign 2
- p.Arg523= Multiple submitters
- c.918-5T>C Single submitter
Likely benign 2
- p.Arg114Gly Single submitter
- p.Arg133Gln Single submitter
Uncertain significance 66
- p.Ala124Val Single submitter ⚠
- p.Arg133Leu Single submitter ⚠
- p.Arg272Gly Single submitter ⚠
- p.Arg28Lys Single submitter ⚠
- p.Arg366Gln Single submitter ⚠
- p.Arg374Trp Single submitter ⚠
- p.Arg396Lys Single submitter ⚠
- p.Arg406His Single submitter ⚠
- p.Arg521His Single submitter ⚠
- p.Asn283Ser Single submitter ⚠
- p.Asn340Tyr Single submitter ⚠
- p.Asn447His Single submitter ⚠
- p.Asn97Ser Single submitter ⚠
- p.Asp113Glu Single submitter ⚠
- p.Asp119Asn Single submitter ⚠
- p.Asp119His Single submitter ⚠
- p.Asp176Glu Single submitter ⚠
- p.Asp213Asn Single submitter ⚠
- p.Asp21Gly Single submitter ⚠
- p.Asp256Tyr Single submitter
- p.Asp353Val Single submitter ⚠
- p.Gln327His Single submitter ⚠
- p.Gln501Pro Single submitter ⚠
- p.Glu225Gln Single submitter ⚠
- p.Glu31Gln Single submitter ⚠
- p.Glu378Lys Single submitter ⚠
- p.Glu505Lys Single submitter ⚠
- p.Gly602Ser Single submitter ⚠
- p.His158Arg Single submitter ⚠
- p.His387Gln Single submitter ⚠
- p.His601Tyr Single submitter ⚠
- p.Ile199Thr Single submitter ⚠
- p.Ile33Met Single submitter ⚠
- p.Ile399Arg Single submitter ⚠
- p.Leu163Val Single submitter ⚠
- p.Leu592Pro Single submitter ⚠
- p.Leu60Ile Single submitter ⚠
- p.Leu618Phe Single submitter ⚠
- p.Lys180Arg Single submitter ⚠
- p.Lys259Ter Single submitter
- p.Lys304Asn Single submitter ⚠
- p.Lys506Arg Single submitter ⚠
- p.Lys511Asn Single submitter ⚠
- p.Met107Val Single submitter ⚠
- p.Met383Ile Single submitter ⚠
- p.Met558Val Single submitter
- p.Met598Leu Single submitter ⚠
- p.Met598Thr Single submitter ⚠
- p.Met89Val Single submitter ⚠
- p.Phe325Ser Single submitter ⚠
- p.Pro126Ser Single submitter ⚠
- p.Pro136Ala Single submitter ⚠
- p.Pro136Arg Single submitter ⚠
- p.Pro136Ser Single submitter ⚠
- p.Pro156Leu Single submitter ⚠
- p.Pro428Ser Single submitter ⚠
- p.Ser656Pro Single submitter ⚠
- p.Ser656Thr Single submitter ⚠
- p.Thr323Ala Single submitter ⚠
- p.Thr557Ala Single submitter ⚠
- p.Thr6Ser Single submitter ⚠
- p.Tyr305Cys Single submitter ⚠
- p.Tyr643Ser Single submitter ⚠
- p.Val346Leu Single submitter ⚠
- p.Val583Ile Single submitter ⚠
- p.Val623Met Single submitter ⚠