TLE2 — 127 ClinVar variants
All ClinVar germline TLE2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →
10 Likely benign · 117 Uncertain significance
Full TLE2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 113
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 90
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TLE2 p.Ala110Thr Uncertain significance Single submitter
- TLE2 p.Ala133Val Uncertain significance Single submitter
- TLE2 p.Ala164Val Uncertain significance Single submitter
- TLE2 p.Ala167Val Uncertain significance Single submitter
- TLE2 p.Ala168Val Uncertain significance Single submitter
- TLE2 p.Ala187Ser Uncertain significance Single submitter
- TLE2 p.Ala187Val Uncertain significance Single submitter
- TLE2 p.Ala192Val Uncertain significance Single submitter
- TLE2 p.Ala273Thr Uncertain significance Single submitter
- TLE2 p.Ala328Gly Uncertain significance Single submitter
- TLE2 p.Ala331Thr Uncertain significance Single submitter
- TLE2 p.Ala37Asp Uncertain significance Single submitter
- TLE2 p.Ala533Val Uncertain significance Single submitter
- TLE2 p.Arg109Cys Uncertain significance Single submitter
- TLE2 p.Arg141His Uncertain significance Single submitter
- TLE2 p.Arg174His Uncertain significance Single submitter
- TLE2 p.Arg205Gln Uncertain significance Single submitter
- TLE2 p.Arg265Cys Uncertain significance Single submitter
- TLE2 p.Arg266Gln Uncertain significance Single submitter
- TLE2 p.Arg538Leu Uncertain significance Single submitter
- TLE2 p.Arg660Cys Uncertain significance Single submitter
- TLE2 p.Arg722Lys Uncertain significance Single submitter
- TLE2 p.Arg83Cys Uncertain significance Single submitter
- TLE2 p.Arg83His Uncertain significance Single submitter
- TLE2 p.Asp229Asn Uncertain significance Single submitter
- TLE2 p.Asp26Asn Uncertain significance Single submitter
- TLE2 p.Asp498Gly Uncertain significance Single submitter
- TLE2 p.Asp599His Uncertain significance Single submitter
- TLE2 p.Asp599Val Uncertain significance Single submitter
- TLE2 p.Asp733His Uncertain significance Single submitter
- TLE2 p.Cys566Ser Uncertain significance Single submitter
- TLE2 p.Gln102His Uncertain significance Single submitter
- TLE2 p.Gln165Lys Uncertain significance Single submitter
- TLE2 p.Glu31Lys Uncertain significance Single submitter
- TLE2 p.Glu458Lys Uncertain significance Single submitter
- TLE2 p.Glu79Gln Uncertain significance Single submitter
- TLE2 p.Gly14Ser Uncertain significance Single submitter
- TLE2 p.Gly256Arg Uncertain significance Single submitter
- TLE2 p.Gly356Asp Uncertain significance Single submitter
- TLE2 p.Gly363Arg Uncertain significance Single submitter
- TLE2 p.Gly443Ser Uncertain significance Single submitter
- TLE2 p.Gly587Asp Uncertain significance Single submitter
- TLE2 p.Gly69Arg Uncertain significance Single submitter
- TLE2 p.His375Tyr Uncertain significance Single submitter
- TLE2 p.His59Asn Uncertain significance Single submitter
- TLE2 p.His668Asp Uncertain significance Single submitter
- TLE2 p.Leu361His Uncertain significance Single submitter
- TLE2 p.Leu361Val Uncertain significance Single submitter
- TLE2 p.Lys18Glu Uncertain significance Single submitter
- TLE2 p.Lys214Arg Uncertain significance Single submitter
- TLE2 p.Met581Val Uncertain significance Single submitter
- TLE2 p.Pro128Gln Uncertain significance Single submitter
- TLE2 p.Pro128Ser Uncertain significance Single submitter
- TLE2 p.Pro135Ala Uncertain significance Single submitter
- TLE2 p.Pro135Leu Uncertain significance Single submitter
- TLE2 p.Pro135Thr Uncertain significance Single submitter
- TLE2 p.Pro137Ser Uncertain significance Single submitter
- TLE2 p.Pro188Leu Uncertain significance Single submitter
- TLE2 p.Pro188Ser Uncertain significance Single submitter
- TLE2 p.Pro196Leu Uncertain significance Single submitter
- TLE2 p.Pro247His Uncertain significance Single submitter
- TLE2 p.Pro250Leu Uncertain significance Single submitter
- TLE2 p.Pro295Ser Uncertain significance Single submitter
- TLE2 p.Pro299Thr Uncertain significance Single submitter
- TLE2 p.Pro410Arg Uncertain significance Single submitter
- TLE2 p.Pro445Leu Uncertain significance Single submitter
- TLE2 p.Ser120Asn Uncertain significance Single submitter
- TLE2 p.Ser182Pro Uncertain significance Single submitter
- TLE2 p.Ser195Leu Uncertain significance Single submitter
- TLE2 p.Ser223Ala Uncertain significance Single submitter
- TLE2 p.Ser303Cys Uncertain significance Single submitter
- TLE2 p.Ser346Pro Uncertain significance Single submitter
- TLE2 p.Ser357Pro Uncertain significance Single submitter
- TLE2 p.Ser357Tyr Uncertain significance Single submitter
- TLE2 p.Ser406Phe Uncertain significance Single submitter
- TLE2 p.Ser420Phe Uncertain significance Single submitter
- TLE2 p.Ser51Arg Uncertain significance Single submitter
- TLE2 p.Ser652Gly Uncertain significance Single submitter
- TLE2 p.Ser709Phe Uncertain significance Single submitter
- TLE2 p.Ser731Leu Uncertain significance Single submitter
- TLE2 p.Thr139Ser Uncertain significance Single submitter
- TLE2 p.Thr151Met Uncertain significance Single submitter
- TLE2 p.Thr492Met Uncertain significance Single submitter
- TLE2 p.Thr580Ser Uncertain significance Single submitter
- TLE2 p.Tyr226His Uncertain significance Single submitter
- TLE2 p.Tyr419Cys Uncertain significance Single submitter
- TLE2 p.Val107Ile Uncertain significance Single submitter
- TLE2 p.Val177Met Uncertain significance Single submitter
- TLE2 p.Val432Ile Uncertain significance Single submitter
- TLE2 p.Val738Met Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- TLE2 p.Arg109His Uncertain significance Single submitter
- TLE2 p.Arg388Cys Uncertain significance Single submitter
- TLE2 p.Arg388His Uncertain significance Single submitter
- TLE2 p.Arg401Gln Uncertain significance Single submitter
- TLE2 p.Arg446Trp Uncertain significance Single submitter
- TLE2 p.Arg622His Uncertain significance Single submitter
- TLE2 p.Arg684Trp Uncertain significance Single submitter
- TLE2 p.Glu108Gln Uncertain significance Single submitter
- TLE2 p.Glu542Ala Uncertain significance Single submitter
- TLE2 p.Glu671Lys Uncertain significance Single submitter
- TLE2 p.Gly14Cys Uncertain significance Single submitter
- TLE2 p.Gly414Val Uncertain significance Single submitter
- TLE2 p.Gly427Arg Uncertain significance Single submitter
- TLE2 p.Ile519Val Uncertain significance Single submitter
- TLE2 p.Ile529Val Uncertain significance Single submitter
- TLE2 p.Pro142Leu Uncertain significance Single submitter
- TLE2 p.Pro662Leu Uncertain significance Single submitter
- TLE2 p.Ser130Phe Uncertain significance Single submitter
- TLE2 p.Ser672Asn Uncertain significance Single submitter
-
TLE2 p.Ser705Asn
Likely benign
Single submitter
neutropenia
- TLE2 p.Ser712Leu Uncertain significance Single submitter
- TLE2 p.Val482Met Uncertain significance Single submitter
- TLE2 p.Val561Ile Uncertain significance Single submitter
All TLE2 variants
Likely benign 10
- p.Asn696= Single submitter
- p.Gly316Arg Single submitter neutropenia
- p.Ile92Val Single submitter
- p.Ser228= Single submitter
- p.Ser705Asn Single submitter neutropenia ⚠
- p.Ser709= Single submitter
- p.Ser712= Single submitter
- p.Ser713= Single submitter
- p.Tyr68= Single submitter
- p.Val391Met Single submitter
Uncertain significance 117
- p.Ala110Thr Single submitter ⚠
- p.Ala133Val Single submitter ⚠
- p.Ala164Val Single submitter ⚠
- p.Ala167Val Single submitter ⚠
- p.Ala168Val Single submitter ⚠
- p.Ala187Ser Single submitter ⚠
- p.Ala187Val Single submitter ⚠
- p.Ala192Val Single submitter ⚠
- p.Ala273Thr Single submitter ⚠
- p.Ala328Gly Single submitter ⚠
- p.Ala331Thr Single submitter ⚠
- p.Ala37Asp Single submitter ⚠
- p.Ala533Val Single submitter ⚠
- p.Arg109Cys Single submitter ⚠
- p.Arg109His Single submitter ⚠
- p.Arg141His Single submitter ⚠
- p.Arg174His Single submitter ⚠
- p.Arg205Gln Single submitter ⚠
- p.Arg265Cys Single submitter ⚠
- p.Arg266Gln Single submitter ⚠
- p.Arg388Cys Single submitter ⚠
- p.Arg388His Single submitter ⚠
- p.Arg401Gln Single submitter ⚠
- p.Arg446Trp Single submitter ⚠
- p.Arg538Leu Single submitter ⚠
- p.Arg603Gly Single submitter
- p.Arg622His Single submitter ⚠
- p.Arg660Cys Single submitter ⚠
- p.Arg684Trp Single submitter ⚠
- p.Arg722Lys Single submitter ⚠
- p.Arg83Cys Single submitter ⚠
- p.Arg83His Single submitter ⚠
- p.Asp229Asn Single submitter ⚠
- p.Asp26Asn Single submitter ⚠
- p.Asp498Gly Single submitter ⚠
- p.Asp599His Single submitter ⚠
- p.Asp599Val Single submitter ⚠
- p.Asp733His Single submitter ⚠
- p.Cys566Ser Single submitter ⚠
- p.Gln102His Single submitter ⚠
- p.Gln165Lys Single submitter ⚠
- p.Glu108Gln Single submitter ⚠
- p.Glu31Lys Single submitter ⚠
- p.Glu458Lys Single submitter ⚠
- p.Glu542Ala Single submitter ⚠
- p.Glu671Lys Single submitter ⚠
- p.Glu79Gln Single submitter ⚠
- p.Gly123Arg Single submitter
- p.Gly14Cys Single submitter ⚠
- p.Gly14Ser Single submitter ⚠
- p.Gly256Arg Single submitter ⚠
- p.Gly356Asp Single submitter ⚠
- p.Gly363Arg Single submitter ⚠
- p.Gly414Val Single submitter ⚠
- p.Gly427Arg Single submitter ⚠
- p.Gly443Ser Single submitter ⚠
- p.Gly587Asp Single submitter ⚠
- p.Gly69Arg Single submitter ⚠
- p.His375Tyr Single submitter ⚠
- p.His59Asn Single submitter ⚠
- p.His668Asp Single submitter ⚠
- p.Ile519Val Single submitter ⚠
- p.Ile529Val Single submitter ⚠
- p.Leu361His Single submitter ⚠
- p.Leu361Val Single submitter ⚠
- p.Lys18Glu Single submitter ⚠
- p.Lys214Arg Single submitter ⚠
- p.Met429Thr Single submitter
- p.Met581Val Single submitter ⚠
- p.Pro128Gln Single submitter ⚠
- p.Pro128Ser Single submitter ⚠
- p.Pro135Ala Single submitter ⚠
- p.Pro135Leu Single submitter ⚠
- p.Pro135Thr Single submitter ⚠
- p.Pro137Ser Single submitter ⚠
- p.Pro142Leu Single submitter ⚠
- p.Pro188Leu Single submitter ⚠
- p.Pro188Ser Single submitter ⚠
- p.Pro196Leu Single submitter ⚠
- p.Pro247His Single submitter ⚠
- p.Pro250Leu Single submitter ⚠
- p.Pro295Ser Single submitter ⚠
- p.Pro299Thr Single submitter ⚠
- p.Pro410Arg Single submitter ⚠
- p.Pro445Leu Single submitter ⚠
- p.Pro662Leu Single submitter ⚠
- p.Ser120Asn Single submitter ⚠
- p.Ser130Phe Single submitter ⚠
- p.Ser182Pro Single submitter ⚠
- p.Ser195Leu Single submitter ⚠
- p.Ser223Ala Single submitter ⚠
- p.Ser303Cys Single submitter ⚠
- p.Ser346Pro Single submitter ⚠
- p.Ser357Pro Single submitter ⚠
- p.Ser357Tyr Single submitter ⚠
- p.Ser406Phe Single submitter ⚠
- p.Ser420Phe Single submitter ⚠
- p.Ser51Arg Single submitter ⚠
- p.Ser652Gly Single submitter ⚠
- p.Ser672Asn Single submitter ⚠
- p.Ser709Phe Single submitter ⚠
- p.Ser712Leu Single submitter ⚠
- p.Ser731Leu Single submitter ⚠
- p.Thr139Ser Single submitter ⚠
- p.Thr151Met Single submitter ⚠
- p.Thr492Met Single submitter ⚠
- p.Thr580Ser Single submitter ⚠
- p.Tyr226His Single submitter ⚠
- p.Tyr419Cys Single submitter ⚠
- p.Tyr739Phe Single submitter
- p.Val107Ile Single submitter ⚠
- p.Val177Met Single submitter ⚠
- p.Val432Ile Single submitter ⚠
- p.Val482Met Single submitter ⚠
- p.Val561Ile Single submitter ⚠
- p.Val738Met Single submitter ⚠
- p.Val81Gly Single submitter