Sugi Variant

Sugi Variant/TLL1

TLL1 — 222 ClinVar variants

All ClinVar germline TLL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 129 flagged for review →

2 Pathogenic · 1 Likely pathogenic · 4 Conflicting · 34 Benign · 3 Benign/Likely benign · 43 Likely benign · 135 Uncertain significance

Full TLL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 129

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 3

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 106

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 19

The independent predictors disagree with each other — read with care.

All TLL1 variants

Pathogenic 2

Likely pathogenic 1

Conflicting classifications of pathogenicity 4

Benign 34

Benign/Likely benign 3

Likely benign 43

Uncertain significance 135