TLR2 — 110 ClinVar variants
All ClinVar germline TLR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 82 flagged for review →
3 Conflicting · 8 Benign · 2 Benign/Likely benign · 14 Likely benign · 83 Uncertain significance
Full TLR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 82
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
TLR2 p.Ile91Val
Conflicting
Single submitter
colorectal cancer
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TLR2 p.Ala780Ser Uncertain significance Single submitter
- TLR2 p.Ala781Val Uncertain significance Single submitter
- TLR2 p.Arg32Cys Uncertain significance Single submitter
-
TLR2 p.Arg447Gln
Uncertain significance
Single submitter
leprosy, susceptibility to, 3
- TLR2 p.Arg611Cys Uncertain significance Single submitter
- TLR2 p.Arg63Gly Uncertain significance Single submitter
- TLR2 p.Asn130Asp Uncertain significance Single submitter
- TLR2 p.Asn130Ser Uncertain significance Single submitter
- TLR2 p.Asn158Thr Uncertain significance Single submitter
- TLR2 p.Asn24Ser Uncertain significance Single submitter
- TLR2 p.Asn638His Uncertain significance Single submitter
- TLR2 p.Asp160Gly Uncertain significance Single submitter
- TLR2 p.Asp231Gly Uncertain significance Single submitter
- TLR2 p.Cys30Arg Uncertain significance Single submitter
- TLR2 p.Cys750Arg Uncertain significance Single submitter
- TLR2 p.Gln209Leu Uncertain significance Single submitter
- TLR2 p.Gln549Lys Uncertain significance Single submitter
- TLR2 p.Gln573Arg Uncertain significance Single submitter
- TLR2 p.Gln661Arg Uncertain significance Single submitter
- TLR2 p.Glu336Asp Uncertain significance Single submitter
- TLR2 p.Glu336Lys Uncertain significance Single submitter
- TLR2 p.Glu375Lys Uncertain significance Single submitter
- TLR2 p.Glu738Lys Uncertain significance Single submitter
- TLR2 p.Gly307Ser Uncertain significance Single submitter
- TLR2 p.Gly38Asp Uncertain significance Single submitter
- TLR2 p.His202Leu Uncertain significance Single submitter
- TLR2 p.His721Arg Uncertain significance Single submitter
- TLR2 p.Ile418Val Uncertain significance Single submitter
- TLR2 p.Ile64Val Uncertain significance Single submitter
- TLR2 p.Ile740Leu Uncertain significance Single submitter
- TLR2 p.Ile740Val Uncertain significance Single submitter
- TLR2 p.Leu242Pro Uncertain significance Single submitter
- TLR2 p.Leu289Val Uncertain significance Single submitter
- TLR2 p.Leu389Pro Uncertain significance Single submitter
- TLR2 p.Leu409Ser Uncertain significance Single submitter
- TLR2 p.Leu410Val Uncertain significance Single submitter
- TLR2 p.Leu625Pro Uncertain significance Single submitter
- TLR2 p.Met621Ile Uncertain significance Single submitter
- TLR2 p.Ser146Cys Uncertain significance Single submitter
- TLR2 p.Ser424Cys Uncertain significance Single submitter
- TLR2 p.Ser465Asn Uncertain significance Single submitter
- TLR2 p.Ser496Phe Uncertain significance Single submitter
- TLR2 p.Ser583Leu Uncertain significance Single submitter
- TLR2 p.Ser696Arg Uncertain significance Single submitter
- TLR2 p.Ser784Phe Uncertain significance Single submitter
- TLR2 p.Thr127Ile Uncertain significance Single submitter
- TLR2 p.Thr142Ile Uncertain significance Single submitter
- TLR2 p.Thr255Ile Uncertain significance Single submitter
- TLR2 p.Thr491Ala Uncertain significance Single submitter
- TLR2 p.Thr758Ser Uncertain significance Single submitter
- TLR2 p.Trp434Arg Uncertain significance Single submitter
- TLR2 p.Val218Ile Uncertain significance Single submitter
- TLR2 p.Val351Phe Uncertain significance Single submitter
- TLR2 p.Val578Ile Uncertain significance Single submitter
- TLR2 p.Val8Leu Uncertain significance Single submitter
- TLR2 p.Met766Val Uncertain significance No assertion criteria
- TLR2 p.Ser40Leu Uncertain significance No assertion criteria
Predictors split 24
The independent predictors disagree with each other — read with care.
- TLR2 p.Phe217Ser Benign/Likely benign Multiple submitters
- TLR2 p.Arg579Cys Uncertain significance Single submitter
- TLR2 p.Arg650Trp Uncertain significance Single submitter
-
TLR2 p.Arg748Cys
Uncertain significance
Single submitter
Mycobacterium tuberculosis, susceptibility to
- TLR2 p.Arg748Gly Uncertain significance Single submitter
- TLR2 p.Arg771Trp Uncertain significance Single submitter
- TLR2 p.Asn77Tyr Uncertain significance Single submitter
- TLR2 p.Asp169Tyr Uncertain significance Single submitter
- TLR2 p.Cys353Tyr Uncertain significance Single submitter
- TLR2 p.Glu649Lys Uncertain significance Single submitter
- TLR2 p.Glu727Val Uncertain significance Single submitter
- TLR2 p.Gly34Ser Uncertain significance Single submitter
- TLR2 p.Gly406Arg Uncertain significance Single submitter
- TLR2 p.Gly406Glu Uncertain significance Single submitter
- TLR2 p.Leu144Phe Uncertain significance Single submitter
- TLR2 p.Lys150Ile Uncertain significance Single submitter
- TLR2 p.Phe325Leu Uncertain significance Single submitter
- TLR2 p.Pro477Leu Likely benign Single submitter
- TLR2 p.Pro499Leu Uncertain significance Single submitter
- TLR2 p.Pro668Ser Uncertain significance Single submitter
- TLR2 p.Pro669Arg Uncertain significance Single submitter
- TLR2 p.Ser18Tyr Uncertain significance Single submitter
- TLR2 p.Ser243Cys Uncertain significance Single submitter
- TLR2 p.Ser388Cys Uncertain significance Single submitter
All TLR2 variants
Conflicting classifications of pathogenicity 3
- p.Ile91Val Single submitter colorectal cancer ⚠
- p.Asn199= No assertion criteria COVID-19–associated multisystem inflammatory syndrome in adults
- p.Ser450= No assertion criteria COVID-19–associated multisystem inflammatory syndrome in adults
Benign 8
- p.Arg579His Multiple submitters
- p.Gly38= Multiple submitters
- p.Leu213= Multiple submitters
- p.Ala400= No assertion criteria TLR2-related disorder
- p.Asn729Ser No assertion criteria TLR2-related disorder
- p.Leu563= No assertion criteria TLR2-related disorder
- p.Phe707= No assertion criteria TLR2-related disorder
- p.Thr411Ile No assertion criteria TLR2-related disorder
Benign/Likely benign 2
- p.Leu542= Multiple submitters Mycobacterium tuberculosis, susceptibility to
- p.Phe217Ser Multiple submitters ⚠
Likely benign 14
- p.Arg571His Multiple submitters
- p.Asp231= Single submitter
- p.Gln574= Single submitter
- p.Glu407= Single submitter
- p.Pro477Leu Single submitter ⚠
- p.Ser636Arg Single submitter
- p.Thr163= Single submitter
- p.Thr605Met Single submitter
- p.Val220Leu Single submitter
- p.Val269Leu Single submitter
- p.Ala26Val No assertion criteria TLR2-related disorder
- p.Leu81Pro No assertion criteria TLR2-related disorder
- p.Pro456= No assertion criteria TLR2-related disorder
- p.Thr65= No assertion criteria TLR2-related disorder
Uncertain significance 83
- p.Ala780Ser Single submitter ⚠
- p.Ala781Val Single submitter ⚠
- p.Arg32Cys Single submitter ⚠
- p.Arg447Gln Single submitter leprosy, susceptibility to, 3 ⚠
- p.Arg447Ter Single submitter colorectal cancer
- p.Arg579Cys Single submitter ⚠
- p.Arg611Cys Single submitter ⚠
- p.Arg63Gly Single submitter ⚠
- p.Arg650Trp Single submitter ⚠
- p.Arg748Cys Single submitter Mycobacterium tuberculosis, susceptibility to ⚠
- p.Arg748Gly Single submitter ⚠
- p.Arg771Trp Single submitter ⚠
- p.Asn130Asp Single submitter ⚠
- p.Asn130Ser Single submitter ⚠
- p.Asn158Thr Single submitter ⚠
- p.Asn24Ser Single submitter ⚠
- p.Asn638His Single submitter ⚠
- p.Asn77Tyr Single submitter ⚠
- p.Asp160Gly Single submitter ⚠
- p.Asp169Tyr Single submitter ⚠
- p.Asp231Gly Single submitter ⚠
- p.Cys30Arg Single submitter ⚠
- p.Cys353Ter Single submitter colorectal cancer
- p.Cys353Tyr Single submitter ⚠
- p.Cys750Arg Single submitter ⚠
- p.Gln209Leu Single submitter ⚠
- p.Gln549Lys Single submitter ⚠
- p.Gln573Arg Single submitter ⚠
- p.Gln661Arg Single submitter ⚠
- p.Glu336Asp Single submitter ⚠
- p.Glu336Lys Single submitter ⚠
- p.Glu375Lys Single submitter ⚠
- p.Glu649Lys Single submitter ⚠
- p.Glu727Val Single submitter ⚠
- p.Glu738Lys Single submitter ⚠
- p.Gly307Ser Single submitter ⚠
- p.Gly34Ser Single submitter ⚠
- p.Gly38Asp Single submitter ⚠
- p.Gly406Arg Single submitter ⚠
- p.Gly406Glu Single submitter ⚠
- p.His202Leu Single submitter ⚠
- p.His721Arg Single submitter ⚠
- p.Ile418Val Single submitter ⚠
- p.Ile64Val Single submitter ⚠
- p.Ile740Leu Single submitter ⚠
- p.Ile740Val Single submitter ⚠
- p.Leu144Phe Single submitter ⚠
- p.Leu242Pro Single submitter ⚠
- p.Leu289Val Single submitter ⚠
- p.Leu389Pro Single submitter ⚠
- p.Leu409Ser Single submitter ⚠
- p.Leu410Val Single submitter ⚠
- p.Leu625Pro Single submitter ⚠
- p.Lys150Ile Single submitter ⚠
- p.Lys630Met Single submitter
- p.Met621Ile Single submitter ⚠
- p.Phe325Leu Single submitter ⚠
- p.Pro499Leu Single submitter ⚠
- p.Pro668Ser Single submitter ⚠
- p.Pro669Arg Single submitter ⚠
- p.Ser101fs Single submitter colorectal cancer
- p.Ser146Cys Single submitter ⚠
- p.Ser18Tyr Single submitter ⚠
- p.Ser243Cys Single submitter ⚠
- p.Ser388Cys Single submitter ⚠
- p.Ser424Cys Single submitter ⚠
- p.Ser465Asn Single submitter ⚠
- p.Ser496Phe Single submitter ⚠
- p.Ser583Leu Single submitter ⚠
- p.Ser696Arg Single submitter ⚠
- p.Ser784Phe Single submitter ⚠
- p.Thr127Ile Single submitter ⚠
- p.Thr142Ile Single submitter ⚠
- p.Thr255Ile Single submitter ⚠
- p.Thr491Ala Single submitter ⚠
- p.Thr758Ser Single submitter ⚠
- p.Trp434Arg Single submitter ⚠
- p.Val218Ile Single submitter ⚠
- p.Val351Phe Single submitter ⚠
- p.Val578Ile Single submitter ⚠
- p.Val8Leu Single submitter ⚠
- p.Met766Val No assertion criteria ⚠
- p.Ser40Leu No assertion criteria ⚠