TLR4 — 113 ClinVar variants
All ClinVar germline TLR4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 81 flagged for review →
1 Conflicting · 7 Benign · 3 Benign/Likely benign · 21 Likely benign · 81 Uncertain significance
Full TLR4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 81
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 62
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TLR4 p.Ala121Ser Uncertain significance Single submitter
- TLR4 p.Ala133Thr Uncertain significance Single submitter
- TLR4 p.Ala222Thr Uncertain significance Single submitter
- TLR4 p.Ala251Thr Uncertain significance Single submitter
- TLR4 p.Ala276Ser Uncertain significance Single submitter
- TLR4 p.Ala366Gly Uncertain significance Single submitter
- TLR4 p.Arg496Lys Uncertain significance Single submitter
- TLR4 p.Arg763Cys Uncertain significance Single submitter
- TLR4 p.Asn205Ile Uncertain significance Single submitter
- TLR4 p.Asn282Asp Uncertain significance Single submitter
- TLR4 p.Asn305Asp Uncertain significance Single submitter
- TLR4 p.Asn309Tyr Uncertain significance Single submitter
- TLR4 p.Asn339Asp Uncertain significance Single submitter
- TLR4 p.Asn339Lys Uncertain significance Single submitter
- TLR4 p.Asn35Asp Uncertain significance Single submitter
- TLR4 p.Asn365Asp Uncertain significance Single submitter
- TLR4 p.Asn365Ser Uncertain significance Single submitter
- TLR4 p.Asn464Ile Uncertain significance Single submitter
- TLR4 p.Asn624His Uncertain significance Single submitter
- TLR4 p.Glu142Asp Uncertain significance Single submitter
- TLR4 p.Glu336Lys Uncertain significance Single submitter
- TLR4 p.Glu563Gly Uncertain significance Single submitter
- TLR4 p.Glu608Lys Uncertain significance Single submitter
- TLR4 p.Glu784Gln Uncertain significance Single submitter
- TLR4 p.Glu824Asp Uncertain significance Single submitter
- TLR4 p.Gly147Arg Uncertain significance Single submitter
- TLR4 p.Gly343Val Uncertain significance Single submitter
- TLR4 p.Gly825Arg Uncertain significance Single submitter
- TLR4 p.His456Tyr Uncertain significance Single submitter
- TLR4 p.His587Gln Uncertain significance Single submitter
- TLR4 p.His657Tyr Uncertain significance Single submitter
- TLR4 p.Ile146Val Uncertain significance Single submitter
- TLR4 p.Ile247Thr Uncertain significance Single submitter
- TLR4 p.Ile301Val Uncertain significance Single submitter
- TLR4 p.Leu203Val Uncertain significance Single submitter
- TLR4 p.Leu228Phe Uncertain significance Single submitter
- TLR4 p.Leu495Arg Uncertain significance Single submitter
- TLR4 p.Leu600Phe Uncertain significance Single submitter
- TLR4 p.Leu61Arg Uncertain significance Single submitter
- TLR4 p.Lys186Arg Uncertain significance Single submitter
- TLR4 p.Met41Val Uncertain significance Single submitter
- TLR4 p.Met437Thr Uncertain significance Single submitter
- TLR4 p.Met557Thr Uncertain significance Single submitter
- TLR4 p.Met629Ile Uncertain significance Single submitter
- TLR4 p.Pro214Arg Uncertain significance Single submitter
- TLR4 p.Pro619Ser Uncertain significance Single submitter
- TLR4 p.Ser116Gly Uncertain significance Single submitter
- TLR4 p.Ser471Cys Uncertain significance Single submitter
- TLR4 p.Ser482Phe Uncertain significance Single submitter
- TLR4 p.Ser559Phe Uncertain significance Single submitter
- TLR4 p.Ser622Asn Uncertain significance Single submitter
- TLR4 p.Ser682Arg Uncertain significance Single submitter
- TLR4 p.Ser838Phe Uncertain significance Single submitter
- TLR4 p.Thr56Ala Uncertain significance Single submitter
- TLR4 p.Tyr72Cys Uncertain significance Single submitter
- TLR4 p.Val242Ile Uncertain significance Single submitter
- TLR4 p.Val310Ile Uncertain significance Single submitter
- TLR4 p.Val774Met Uncertain significance Single submitter
- TLR4 p.Val783Ala Uncertain significance Single submitter
- TLR4 p.Val82Gly Uncertain significance Single submitter
- TLR4 p.Val82Leu Uncertain significance Single submitter
- TLR4 p.Val770Ile Uncertain significance No assertion criteria
Predictors split 19
The independent predictors disagree with each other — read with care.
- TLR4 p.Arg812Ile Uncertain significance Single submitter
- TLR4 p.Cys281Tyr Likely benign Single submitter
- TLR4 p.Cys391Trp Uncertain significance Single submitter
- TLR4 p.Gln430Pro Uncertain significance Single submitter
- TLR4 p.Glu336Gly Uncertain significance Single submitter
- TLR4 p.Glu376Asp Uncertain significance Single submitter
- TLR4 p.Ile634Thr Uncertain significance Single submitter
- TLR4 p.Leu174Val Uncertain significance Single submitter
- TLR4 p.Leu427Val Uncertain significance Single submitter
- TLR4 p.Leu549Val Uncertain significance Single submitter
- TLR4 p.Leu571Ile Uncertain significance Single submitter
- TLR4 p.Leu59Val Uncertain significance Single submitter
-
TLR4 p.Lys477Asn
Uncertain significance
Single submitter
lung adenocarcinoma
- TLR4 p.Pro202Ser Uncertain significance Single submitter
- TLR4 p.Pro49Ala Uncertain significance Single submitter
- TLR4 p.Ser381Gly Uncertain significance Single submitter
- TLR4 p.Tyr540Asp Uncertain significance Single submitter
- TLR4 p.Tyr652Cys Uncertain significance Single submitter
-
TLR4 p.Ser73Arg
Benign
No assertion criteria
TLR4-related disorder
All TLR4 variants
Conflicting classifications of pathogenicity 1
- p.Asn176fs No assertion criteria Susceptibility to severe COVID-19
Benign 7
- c.*2010G>C Multiple submitters
- p.Gln163= Multiple submitters
- p.Lys653= Multiple submitters
- p.Asp299Gly Single submitter COPD, severe early onset
- p.Thr399Ile Single submitter COPD, severe early onset
- p.Gln510His No assertion criteria TLR4-related disorder
- p.Ser73Arg No assertion criteria TLR4-related disorder ⚠
Benign/Likely benign 3
Likely benign 21
- p.Phe443= Multiple submitters
- c.*455G>A Single submitter lung adenocarcinoma
- c.*6290C>A Single submitter squamous cell carcinoma
- p.Arg227Lys Single submitter
- p.Arg606Gln Single submitter
- p.Arg763His Single submitter
- p.Asn235Ser Single submitter
- p.Cys281Tyr Single submitter ⚠
- p.Gln507= Single submitter
- p.Gly828Asp Single submitter
- p.Gly830Glu Single submitter
- p.His179Tyr Single submitter
- p.Leu778= Single submitter
- p.Phe263= Single submitter
- p.Ser545= Single submitter
- p.Tyr46Cys Single submitter
- p.Val604Ala Single submitter
- p.Val774Leu Single submitter
- p.Ile633= No assertion criteria TLR4-related disorder
- p.Ile93Val No assertion criteria TLR4-related disorder
- p.Thr175Ala No assertion criteria TLR4-related disorder
Uncertain significance 81
- c.*4092C>T Single submitter lung adenocarcinoma
- p.Ala121Ser Single submitter ⚠
- p.Ala133Thr Single submitter ⚠
- p.Ala222Thr Single submitter ⚠
- p.Ala251Thr Single submitter ⚠
- p.Ala276Ser Single submitter ⚠
- p.Ala366Gly Single submitter ⚠
- p.Arg496Lys Single submitter ⚠
- p.Arg763Cys Single submitter ⚠
- p.Arg812Ile Single submitter ⚠
- p.Asn205Ile Single submitter ⚠
- p.Asn282Asp Single submitter ⚠
- p.Asn305Asp Single submitter ⚠
- p.Asn309Tyr Single submitter ⚠
- p.Asn339Asp Single submitter ⚠
- p.Asn339Lys Single submitter ⚠
- p.Asn35Asp Single submitter ⚠
- p.Asn365Asp Single submitter ⚠
- p.Asn365Ser Single submitter ⚠
- p.Asn464Ile Single submitter ⚠
- p.Asn624His Single submitter ⚠
- p.Cys391Trp Single submitter ⚠
- p.Gln430Pro Single submitter ⚠
- p.Glu142Asp Single submitter ⚠
- p.Glu336Gly Single submitter ⚠
- p.Glu336Lys Single submitter ⚠
- p.Glu376Asp Single submitter ⚠
- p.Glu563Gly Single submitter ⚠
- p.Glu608Lys Single submitter ⚠
- p.Glu784Gln Single submitter ⚠
- p.Glu824Asp Single submitter ⚠
- p.Gly147Arg Single submitter ⚠
- p.Gly343Val Single submitter ⚠
- p.Gly825Arg Single submitter ⚠
- p.His456Tyr Single submitter ⚠
- p.His587Gln Single submitter ⚠
- p.His657Tyr Single submitter ⚠
- p.Ile146Val Single submitter ⚠
- p.Ile247Thr Single submitter ⚠
- p.Ile301Val Single submitter ⚠
- p.Ile634Thr Single submitter ⚠
- p.Leu174Val Single submitter ⚠
- p.Leu203Val Single submitter ⚠
- p.Leu228Phe Single submitter ⚠
- p.Leu427Val Single submitter ⚠
- p.Leu495Arg Single submitter ⚠
- p.Leu549Val Single submitter ⚠
- p.Leu571Ile Single submitter ⚠
- p.Leu59Val Single submitter ⚠
- p.Leu600Phe Single submitter ⚠
- p.Leu61Arg Single submitter ⚠
- p.Lys186Arg Single submitter ⚠
- p.Lys477Asn Single submitter lung adenocarcinoma ⚠
- p.Met41Val Single submitter ⚠
- p.Met437Thr Single submitter ⚠
- p.Met557Thr Single submitter ⚠
- p.Met629Ile Single submitter ⚠
- p.Pro202Ser Single submitter ⚠
- p.Pro214Arg Single submitter ⚠
- p.Pro49Ala Single submitter ⚠
- p.Pro619Ser Single submitter ⚠
- p.Ser116Gly Single submitter ⚠
- p.Ser381Gly Single submitter ⚠
- p.Ser471Cys Single submitter ⚠
- p.Ser482Phe Single submitter ⚠
- p.Ser559Phe Single submitter ⚠
- p.Ser622Asn Single submitter ⚠
- p.Ser682Arg Single submitter ⚠
- p.Ser838Phe Single submitter ⚠
- p.Thr56Ala Single submitter ⚠
- p.Tyr540Asp Single submitter ⚠
- p.Tyr652Cys Single submitter ⚠
- p.Tyr72Cys Single submitter ⚠
- p.Val242Ile Single submitter ⚠
- p.Val310Ile Single submitter ⚠
- p.Val774Met Single submitter ⚠
- p.Val783Ala Single submitter ⚠
- p.Val82Gly Single submitter ⚠
- p.Val82Leu Single submitter ⚠
- p.Trp593Ter No assertion criteria
- p.Val770Ile No assertion criteria ⚠