TLR6 — 89 ClinVar variants
All ClinVar germline TLR6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 80 flagged for review →
4 Benign · 4 Likely benign · 81 Uncertain significance
Full TLR6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 80
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TLR6 p.Ala155Val Uncertain significance Single submitter
- TLR6 p.Ala35Ser Uncertain significance Single submitter
- TLR6 p.Ala644Asp Uncertain significance Single submitter
- TLR6 p.Ala65Thr Uncertain significance Single submitter
- TLR6 p.Arg293Cys Uncertain significance Single submitter
- TLR6 p.Arg625Trp Uncertain significance Single submitter
- TLR6 p.Arg626Cys Uncertain significance Single submitter
- TLR6 p.Arg770Cys Uncertain significance Single submitter
- TLR6 p.Asn285Ser Uncertain significance Single submitter
- TLR6 p.Asn314Asp Uncertain significance Single submitter
- TLR6 p.Asn359Asp Uncertain significance Single submitter
- TLR6 p.Asn630Ile Uncertain significance Single submitter
- TLR6 p.Asn639Lys Uncertain significance Single submitter
- TLR6 p.Asn677His Uncertain significance Single submitter
- TLR6 p.Asn677Ser Uncertain significance Single submitter
- TLR6 p.Asn722Ser Uncertain significance Single submitter
- TLR6 p.Asn776Ser Uncertain significance Single submitter
- TLR6 p.Asp340Tyr Uncertain significance Single submitter
- TLR6 p.Asp4Asn Uncertain significance Single submitter
- TLR6 p.Asp58Asn Uncertain significance Single submitter
- TLR6 p.Asp668Tyr Uncertain significance Single submitter
- TLR6 p.Cys561Gly Uncertain significance Single submitter
- TLR6 p.Gln236Leu Uncertain significance Single submitter
- TLR6 p.Gln637Arg Uncertain significance Single submitter
- TLR6 p.Gln741Arg Uncertain significance Single submitter
- TLR6 p.Glu187Lys Uncertain significance Single submitter
- TLR6 p.Glu310Val Uncertain significance Single submitter
- TLR6 p.Glu536Lys Uncertain significance Single submitter
- TLR6 p.Glu665Ala Uncertain significance Single submitter
- TLR6 p.Glu77Lys Uncertain significance Single submitter
- TLR6 p.Gly31Arg Uncertain significance Single submitter
- TLR6 p.Gly681Arg Uncertain significance Single submitter
- TLR6 p.His118Tyr Uncertain significance Single submitter
- TLR6 p.His170Arg Uncertain significance Single submitter
- TLR6 p.His311Tyr Uncertain significance Single submitter
- TLR6 p.His651Arg Uncertain significance Single submitter
- TLR6 p.His749Tyr Uncertain significance Single submitter
- TLR6 p.Ile338Ser Uncertain significance Single submitter
- TLR6 p.Ile544Val Uncertain significance Single submitter
- TLR6 p.Ile631Leu Uncertain significance Single submitter
- TLR6 p.Ile692Thr Uncertain significance Single submitter
- TLR6 p.Leu136Met Uncertain significance Single submitter
- TLR6 p.Leu208Ser Uncertain significance Single submitter
- TLR6 p.Leu256Phe Uncertain significance Single submitter
- TLR6 p.Leu273Val Uncertain significance Single submitter
- TLR6 p.Leu475Trp Uncertain significance Single submitter
- TLR6 p.Leu754Val Uncertain significance Single submitter
- TLR6 p.Lys55Glu Uncertain significance Single submitter
- TLR6 p.Lys747Arg Uncertain significance Single submitter
- TLR6 p.Lys750Arg Uncertain significance Single submitter
- TLR6 p.Lys784Gln Uncertain significance Single submitter
- TLR6 p.Met783Arg Uncertain significance Single submitter
- TLR6 p.Met783Thr Uncertain significance Single submitter
- TLR6 p.Phe74Leu Uncertain significance Single submitter
- TLR6 p.Pro275Ser Uncertain significance Single submitter
- TLR6 p.Ser129Pro Uncertain significance Single submitter
- TLR6 p.Thr250Ala Uncertain significance Single submitter
- TLR6 p.Thr261Met Uncertain significance Single submitter
- TLR6 p.Thr302Met Uncertain significance Single submitter
- TLR6 p.Thr303Ile Uncertain significance Single submitter
- TLR6 p.Thr313Met Uncertain significance Single submitter
- TLR6 p.Thr322Ile Uncertain significance Single submitter
- TLR6 p.Thr585Ser Uncertain significance Single submitter
- TLR6 p.Tyr104Cys Uncertain significance Single submitter
- TLR6 p.Tyr559Cys Uncertain significance Single submitter
- TLR6 p.Tyr614Cys Uncertain significance Single submitter
- TLR6 p.Tyr63Cys Uncertain significance Single submitter
- TLR6 p.Val121Leu Uncertain significance Single submitter
- TLR6 p.Val217Ile Uncertain significance Single submitter
- TLR6 p.Val267Gly Uncertain significance Single submitter
- TLR6 p.Val364Ile Uncertain significance Single submitter
- TLR6 p.Val427Ile Uncertain significance Single submitter
- TLR6 p.Val589Ala Uncertain significance Single submitter
- TLR6 p.Val9Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- TLR6 p.Asp37His Uncertain significance Single submitter
- TLR6 p.Gln111Pro Uncertain significance Single submitter
- TLR6 p.Gln620Pro Uncertain significance Single submitter
- TLR6 p.Leu169Ser Uncertain significance Single submitter
- TLR6 p.Phe515Leu Uncertain significance Single submitter
- TLR6 p.Ser709Thr Uncertain significance Single submitter
All TLR6 variants
Benign 4
- p.Gly592Val Multiple submitters
- p.Thr287= Multiple submitters
- p.Val465Ile Multiple submitters
- p.Met577fs No assertion criteria Abnormality of neuronal migration
Likely benign 4
- p.Arg626His Single submitter
- p.Ile120Val Single submitter
- p.Ile183Val Single submitter
- p.Lys542Gln Single submitter
Uncertain significance 81
- p.Ala155Val Single submitter ⚠
- p.Ala35Ser Single submitter ⚠
- p.Ala644Asp Single submitter ⚠
- p.Ala65Thr Single submitter ⚠
- p.Arg293Cys Single submitter ⚠
- p.Arg625Trp Single submitter ⚠
- p.Arg626Cys Single submitter ⚠
- p.Arg770Cys Single submitter ⚠
- p.Asn285Ser Single submitter ⚠
- p.Asn314Asp Single submitter ⚠
- p.Asn359Asp Single submitter ⚠
- p.Asn630Ile Single submitter ⚠
- p.Asn639Lys Single submitter ⚠
- p.Asn677His Single submitter ⚠
- p.Asn677Ser Single submitter ⚠
- p.Asn722Ser Single submitter ⚠
- p.Asn776Ser Single submitter ⚠
- p.Asp340Tyr Single submitter ⚠
- p.Asp37His Single submitter ⚠
- p.Asp4Asn Single submitter ⚠
- p.Asp58Asn Single submitter ⚠
- p.Asp668Tyr Single submitter ⚠
- p.Cys561Gly Single submitter ⚠
- p.Gln111Pro Single submitter ⚠
- p.Gln236Leu Single submitter ⚠
- p.Gln620Pro Single submitter ⚠
- p.Gln637Arg Single submitter ⚠
- p.Gln741Arg Single submitter ⚠
- p.Glu187Lys Single submitter ⚠
- p.Glu310Val Single submitter ⚠
- p.Glu536Lys Single submitter ⚠
- p.Glu665Ala Single submitter ⚠
- p.Glu77Lys Single submitter ⚠
- p.Gly31Arg Single submitter ⚠
- p.Gly681Arg Single submitter ⚠
- p.His118Tyr Single submitter ⚠
- p.His170Arg Single submitter ⚠
- p.His311Tyr Single submitter ⚠
- p.His651Arg Single submitter ⚠
- p.His749Tyr Single submitter ⚠
- p.Ile338Ser Single submitter ⚠
- p.Ile544Val Single submitter ⚠
- p.Ile631Leu Single submitter ⚠
- p.Ile692Thr Single submitter ⚠
- p.Leu136Met Single submitter ⚠
- p.Leu169Ser Single submitter ⚠
- p.Leu208Ser Single submitter ⚠
- p.Leu256Phe Single submitter ⚠
- p.Leu273Val Single submitter ⚠
- p.Leu475Trp Single submitter ⚠
- p.Leu754Val Single submitter ⚠
- p.Leu75Gln Single submitter
- p.Lys55Glu Single submitter ⚠
- p.Lys747Arg Single submitter ⚠
- p.Lys750Arg Single submitter ⚠
- p.Lys784Gln Single submitter ⚠
- p.Met783Arg Single submitter ⚠
- p.Met783Thr Single submitter ⚠
- p.Phe515Leu Single submitter ⚠
- p.Phe74Leu Single submitter ⚠
- p.Pro275Ser Single submitter ⚠
- p.Ser129Pro Single submitter ⚠
- p.Ser709Thr Single submitter ⚠
- p.Thr250Ala Single submitter ⚠
- p.Thr261Met Single submitter ⚠
- p.Thr302Met Single submitter ⚠
- p.Thr303Ile Single submitter ⚠
- p.Thr313Met Single submitter ⚠
- p.Thr322Ile Single submitter ⚠
- p.Thr585Ser Single submitter ⚠
- p.Tyr104Cys Single submitter ⚠
- p.Tyr559Cys Single submitter ⚠
- p.Tyr614Cys Single submitter ⚠
- p.Tyr63Cys Single submitter ⚠
- p.Val121Leu Single submitter ⚠
- p.Val217Ile Single submitter ⚠
- p.Val267Gly Single submitter ⚠
- p.Val364Ile Single submitter ⚠
- p.Val427Ile Single submitter ⚠
- p.Val589Ala Single submitter ⚠
- p.Val9Ala Single submitter ⚠