TM9SF3 — 36 ClinVar variants
All ClinVar germline TM9SF3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
2 Benign · 34 Uncertain significance
Full TM9SF3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TM9SF3 p.Ala348Val Uncertain significance Single submitter
- TM9SF3 p.Ala368Thr Uncertain significance Single submitter
- TM9SF3 p.Ala562Thr Uncertain significance Single submitter
- TM9SF3 p.Arg580Gln Uncertain significance Single submitter
- TM9SF3 p.Asn378Ser Uncertain significance Single submitter
- TM9SF3 p.Asp100Glu Uncertain significance Single submitter
- TM9SF3 p.Gln36His Uncertain significance Single submitter
- TM9SF3 p.Glu115Asp Uncertain significance Single submitter
- TM9SF3 p.Ile307Val Uncertain significance Single submitter
- TM9SF3 p.Leu420Met Uncertain significance Single submitter
- TM9SF3 p.Met264Val Uncertain significance Single submitter
- TM9SF3 p.Met313Ile Uncertain significance Single submitter
- TM9SF3 p.Met359Ile Uncertain significance Single submitter
- TM9SF3 p.Met395Thr Uncertain significance Single submitter
- TM9SF3 p.Met566Leu Uncertain significance Single submitter
- TM9SF3 p.Phe376Leu Uncertain significance Single submitter
- TM9SF3 p.Ser576Gly Uncertain significance Single submitter
- TM9SF3 p.Thr157Ile Uncertain significance Single submitter
- TM9SF3 p.Thr335Met Uncertain significance Single submitter
- TM9SF3 p.Thr373Ala Uncertain significance Single submitter
- TM9SF3 p.Thr525Ala Uncertain significance Single submitter
- TM9SF3 p.Tyr154Cys Uncertain significance Single submitter
- TM9SF3 p.Tyr537His Uncertain significance Single submitter
- TM9SF3 p.Val398Ile Uncertain significance Single submitter
- TM9SF3 p.Val405Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All TM9SF3 variants
Benign 2
- c.583-11dup Single submitter
- c.583-3del Single submitter
Uncertain significance 34
- c.1541+1G>C Single submitter
- p.Ala348Val Single submitter ⚠
- p.Ala368Thr Single submitter ⚠
- p.Ala562Thr Single submitter ⚠
- p.Arg580Gln Single submitter ⚠
- p.Asn378Ser Single submitter ⚠
- p.Asn431Ser Single submitter ⚠
- p.Asp100Glu Single submitter ⚠
- p.Cys402Phe Single submitter ⚠
- p.Gln36His Single submitter ⚠
- p.Glu115Asp Single submitter ⚠
- p.Gly68Arg Single submitter ⚠
- p.Ile307Val Single submitter ⚠
- p.Ile437Val Single submitter
- p.Leu420Met Single submitter ⚠
- p.Met264Val Single submitter ⚠
- p.Met313Ile Single submitter ⚠
- p.Met359Ile Single submitter ⚠
- p.Met395Thr Single submitter ⚠
- p.Met566Leu Single submitter ⚠
- p.Met566Thr Single submitter
- p.Phe376Leu Single submitter ⚠
- p.Ser326Asn Single submitter ⚠
- p.Ser560Gly Single submitter ⚠
- p.Ser576Gly Single submitter ⚠
- p.Thr157Ile Single submitter ⚠
- p.Thr335Met Single submitter ⚠
- p.Thr373Ala Single submitter ⚠
- p.Thr525Ala Single submitter ⚠
- p.Tyr154Cys Single submitter ⚠
- p.Tyr537His Single submitter ⚠
- p.Val398Ile Single submitter ⚠
- p.Val405Ile Single submitter ⚠
- p.Ala303_Val304insCysSerGlyCysGlnIlePheAla No assertion criteria