TMED10 — 11 ClinVar variants
All ClinVar germline TMED10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
2 Benign · 9 Uncertain significance
Full TMED10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TMED10 p.Ala67Thr Uncertain significance Single submitter
- TMED10 p.Arg152Gln Uncertain significance Single submitter
- TMED10 p.Gly65Arg Uncertain significance Single submitter
- TMED10 p.Ile161Val Uncertain significance Single submitter
- TMED10 p.Leu84Phe Uncertain significance Single submitter
- TMED10 p.Ser190Thr Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All TMED10 variants
Benign 2
- c.539-28T>C Multiple submitters
- c.539-11dup Single submitter
Uncertain significance 9
- p.Ala67Thr Single submitter ⚠
- p.Arg152Gln Single submitter ⚠
- p.Gly65Arg Single submitter ⚠
- p.Ile161Val Single submitter ⚠
- p.Ile198Thr Single submitter ⚠
- p.Leu84Phe Single submitter ⚠
- p.Met104Thr Single submitter ⚠
- p.Ser190Thr Single submitter ⚠
- p.Val205Leu Single submitter ⚠