TMED9 — 21 ClinVar variants
All ClinVar germline TMED9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
1 Likely benign · 20 Uncertain significance
Full TMED9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TMED9 p.Ala2Pro Uncertain significance Single submitter
- TMED9 p.Arg11Gln Uncertain significance Single submitter
- TMED9 p.Arg11Trp Uncertain significance Single submitter
- TMED9 p.Arg23Trp Uncertain significance Single submitter
- TMED9 p.Arg34Pro Uncertain significance Single submitter
- TMED9 p.Gln201Glu Uncertain significance Single submitter
- TMED9 p.Glu4Gly Uncertain significance Single submitter
- TMED9 p.Gly15Arg Uncertain significance Single submitter
- TMED9 p.Leu25Phe Uncertain significance Single submitter
- TMED9 p.Leu29Val Uncertain significance Single submitter
- TMED9 p.Leu5Val Uncertain significance Single submitter
- TMED9 p.Leu9Phe Uncertain significance Single submitter
- TMED9 p.Thr24Ser Uncertain significance Single submitter
- TMED9 p.Val7Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- TMED9 p.Gly218Ser Uncertain significance Single submitter
- TMED9 p.Leu234Val Uncertain significance Single submitter
- TMED9 p.Leu25Arg Uncertain significance Single submitter
- TMED9 p.Met85Ile Uncertain significance Single submitter
- TMED9 p.Pro55Ala Uncertain significance Single submitter
-
TMED9 p.Leu26Gln
Uncertain significance
No assertion criteria
Monoclonal B-Cell Lymphocytosis
All TMED9 variants
Likely benign 1
- p.Thr16Ala Single submitter
Uncertain significance 20
- p.Ala2Pro Single submitter ⚠
- p.Arg11Gln Single submitter ⚠
- p.Arg11Trp Single submitter ⚠
- p.Arg23Trp Single submitter ⚠
- p.Arg34Pro Single submitter ⚠
- p.Gln201Glu Single submitter ⚠
- p.Glu4Gly Single submitter ⚠
- p.Gly15Arg Single submitter ⚠
- p.Gly218Ser Single submitter ⚠
- p.Leu234Val Single submitter ⚠
- p.Leu25Arg Single submitter ⚠
- p.Leu25Phe Single submitter ⚠
- p.Leu29Val Single submitter ⚠
- p.Leu5Val Single submitter ⚠
- p.Leu9Phe Single submitter ⚠
- p.Met85Ile Single submitter ⚠
- p.Pro55Ala Single submitter ⚠
- p.Thr24Ser Single submitter ⚠
- p.Val7Leu Single submitter ⚠
- p.Leu26Gln No assertion criteria Monoclonal B-Cell Lymphocytosis ⚠