TMEM109 — 28 ClinVar variants
All ClinVar germline TMEM109 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
1 Likely benign · 27 Uncertain significance
Full TMEM109 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TMEM109 p.Ala103Thr Uncertain significance Single submitter
- TMEM109 p.Ala136Ser Uncertain significance Single submitter
- TMEM109 p.Ala170Gly Uncertain significance Single submitter
- TMEM109 p.Ala233Val Uncertain significance Single submitter
- TMEM109 p.Ala87Thr Uncertain significance Single submitter
- TMEM109 p.Ala98Ser Uncertain significance Single submitter
- TMEM109 p.Arg158Gln Uncertain significance Single submitter
- TMEM109 p.Arg201Trp Uncertain significance Single submitter
- TMEM109 p.Arg206Gln Uncertain significance Single submitter
- TMEM109 p.Arg217Gln Uncertain significance Single submitter
- TMEM109 p.Arg227His Uncertain significance Single submitter
- TMEM109 p.Arg229His Uncertain significance Single submitter
- TMEM109 p.Gln211His Uncertain significance Single submitter
- TMEM109 p.Glu243Lys Uncertain significance Single submitter
- TMEM109 p.Gly150Asp Uncertain significance Single submitter
- TMEM109 p.Gly171Ser Uncertain significance Single submitter
- TMEM109 p.Gly218Arg Uncertain significance Single submitter
- TMEM109 p.Val152Ala Uncertain significance Single submitter
- TMEM109 p.Val94Ala Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- TMEM109 p.Ala170Asp Uncertain significance Single submitter
- TMEM109 p.Arg229Cys Uncertain significance Single submitter
- TMEM109 p.Arg232Pro Uncertain significance Single submitter
- TMEM109 p.Arg238Cys Uncertain significance Single submitter
- TMEM109 p.Arg238His Uncertain significance Single submitter
- TMEM109 p.Ser146Cys Uncertain significance Single submitter
- TMEM109 p.Ser183Cys Uncertain significance Single submitter
- TMEM109 p.Val216Gly Uncertain significance Single submitter
All TMEM109 variants
Likely benign 1
- p.Ala118Thr Single submitter
Uncertain significance 27
- p.Ala103Thr Single submitter ⚠
- p.Ala136Ser Single submitter ⚠
- p.Ala170Asp Single submitter ⚠
- p.Ala170Gly Single submitter ⚠
- p.Ala233Val Single submitter ⚠
- p.Ala87Thr Single submitter ⚠
- p.Ala98Ser Single submitter ⚠
- p.Arg158Gln Single submitter ⚠
- p.Arg201Trp Single submitter ⚠
- p.Arg206Gln Single submitter ⚠
- p.Arg217Gln Single submitter ⚠
- p.Arg227His Single submitter ⚠
- p.Arg229Cys Single submitter ⚠
- p.Arg229His Single submitter ⚠
- p.Arg232Pro Single submitter ⚠
- p.Arg238Cys Single submitter ⚠
- p.Arg238His Single submitter ⚠
- p.Gln211His Single submitter ⚠
- p.Glu243Lys Single submitter ⚠
- p.Gly150Asp Single submitter ⚠
- p.Gly171Ser Single submitter ⚠
- p.Gly218Arg Single submitter ⚠
- p.Ser146Cys Single submitter ⚠
- p.Ser183Cys Single submitter ⚠
- p.Val152Ala Single submitter ⚠
- p.Val216Gly Single submitter ⚠
- p.Val94Ala Single submitter ⚠