TMEM140 — 34 ClinVar variants
All ClinVar germline TMEM140 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
3 Likely benign · 31 Uncertain significance
Full TMEM140 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TMEM140 p.Ala104Gly Uncertain significance Single submitter
- TMEM140 p.Arg174Lys Uncertain significance Single submitter
- TMEM140 p.Arg5Lys Uncertain significance Single submitter
- TMEM140 p.Asp41Glu Uncertain significance Single submitter
- TMEM140 p.Gln105Glu Uncertain significance Single submitter
- TMEM140 p.Gln99Lys Uncertain significance Single submitter
- TMEM140 p.Glu57Gly Uncertain significance Single submitter
- TMEM140 p.Ile25Asn Uncertain significance Single submitter
- TMEM140 p.Ile25Thr Uncertain significance Single submitter
- TMEM140 p.Leu160Ser Uncertain significance Single submitter
- TMEM140 p.Leu164Ser Uncertain significance Single submitter
- TMEM140 p.Leu182Ile Uncertain significance Single submitter
- TMEM140 p.Met15Ile Uncertain significance Single submitter
- TMEM140 p.Met15Thr Uncertain significance Single submitter
- TMEM140 p.Thr59Ile Uncertain significance Single submitter
- TMEM140 p.Val117Met Uncertain significance Single submitter
- TMEM140 p.Val21Leu Uncertain significance Single submitter
- TMEM140 p.Val21Met Uncertain significance Single submitter
- TMEM140 p.Val75Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- TMEM140 p.Ala153Pro Uncertain significance Single submitter
- TMEM140 p.Gln63Pro Uncertain significance Single submitter
- TMEM140 p.Gly118Asp Uncertain significance Single submitter
- TMEM140 p.Gly130Ser Uncertain significance Single submitter
- TMEM140 p.Gly37Val Uncertain significance Single submitter
- TMEM140 p.Gly89Arg Uncertain significance Single submitter
- TMEM140 p.Leu93Pro Uncertain significance Single submitter
- TMEM140 p.Met28Ile Uncertain significance Single submitter
- TMEM140 p.Phe171Leu Uncertain significance Single submitter
- TMEM140 p.Ser90Pro Uncertain significance Single submitter
All TMEM140 variants
Likely benign 3
- p.Ala97Ser Single submitter
- p.Arg114Gln Single submitter
- p.Gly3Ser Single submitter
Uncertain significance 31
- p.Ala104Gly Single submitter ⚠
- p.Ala153Pro Single submitter ⚠
- p.Arg174Lys Single submitter ⚠
- p.Arg5Lys Single submitter ⚠
- p.Asp41Glu Single submitter ⚠
- p.Gln105Glu Single submitter ⚠
- p.Gln63Pro Single submitter ⚠
- p.Gln99Lys Single submitter ⚠
- p.Glu57Gly Single submitter ⚠
- p.Gly118Asp Single submitter ⚠
- p.Gly130Ser Single submitter ⚠
- p.Gly37Val Single submitter ⚠
- p.Gly48Ser Single submitter
- p.Gly89Arg Single submitter ⚠
- p.Ile25Asn Single submitter ⚠
- p.Ile25Thr Single submitter ⚠
- p.Leu160Ser Single submitter ⚠
- p.Leu164Ser Single submitter ⚠
- p.Leu182Ile Single submitter ⚠
- p.Leu93Pro Single submitter ⚠
- p.Met15Ile Single submitter ⚠
- p.Met15Thr Single submitter ⚠
- p.Met28Ile Single submitter ⚠
- p.Phe171Leu Single submitter ⚠
- p.Ser90Pro Single submitter ⚠
- p.Thr59Ile Single submitter ⚠
- p.Tyr50Cys Single submitter
- p.Val117Met Single submitter ⚠
- p.Val21Leu Single submitter ⚠
- p.Val21Met Single submitter ⚠
- p.Val75Met Single submitter ⚠