TMEM205 — 35 ClinVar variants
All ClinVar germline TMEM205 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
35 Uncertain significance
Full TMEM205 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TMEM205 p.Ala180Ser Uncertain significance Single submitter
- TMEM205 p.Ala86Asp Uncertain significance Single submitter
- TMEM205 p.Arg104Cys Uncertain significance Single submitter
- TMEM205 p.Arg104His Uncertain significance Single submitter
- TMEM205 p.Arg124Gln Uncertain significance Single submitter
- TMEM205 p.Arg141His Uncertain significance Single submitter
- TMEM205 p.Arg154Cys Uncertain significance Single submitter
- TMEM205 p.Arg159His Uncertain significance Single submitter
- TMEM205 p.Asn175Ser Uncertain significance Single submitter
- TMEM205 p.Asn68Ser Uncertain significance Single submitter
- TMEM205 p.Asp138Asn Uncertain significance Single submitter
- TMEM205 p.Cys171Arg Uncertain significance Single submitter
- TMEM205 p.Cys64Ser Uncertain significance Single submitter
- TMEM205 p.Gln26Lys Uncertain significance Single submitter
- TMEM205 p.Glu3Lys Uncertain significance Single submitter
- TMEM205 p.Gly128Arg Uncertain significance Single submitter
- TMEM205 p.Gly128Trp Uncertain significance Single submitter
- TMEM205 p.Gly63Ser Uncertain significance Single submitter
- TMEM205 p.Gly9Ala Uncertain significance Single submitter
- TMEM205 p.Met13Ile Uncertain significance Single submitter
- TMEM205 p.Met25Thr Uncertain significance Single submitter
- TMEM205 p.Met25Val Uncertain significance Single submitter
- TMEM205 p.Met27Ile Uncertain significance Single submitter
- TMEM205 p.Phe54Leu Uncertain significance Single submitter
- TMEM205 p.Pro148Arg Uncertain significance Single submitter
- TMEM205 p.Trp84Arg Uncertain significance Single submitter
- TMEM205 p.Val172Ile Uncertain significance Single submitter
- TMEM205 p.Val172Phe Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- TMEM205 p.Arg109Cys Uncertain significance Single submitter
- TMEM205 p.Arg141Cys Uncertain significance Single submitter
- TMEM205 p.Arg43Gln Uncertain significance Single submitter
- TMEM205 p.Ser165Pro Uncertain significance Single submitter
- TMEM205 p.Ser174Asn Uncertain significance Single submitter
- TMEM205 p.Val172Asp Uncertain significance Single submitter
All TMEM205 variants
Uncertain significance 35
- p.Ala180Ser Single submitter ⚠
- p.Ala86Asp Single submitter ⚠
- p.Arg104Cys Single submitter ⚠
- p.Arg104His Single submitter ⚠
- p.Arg109Cys Single submitter ⚠
- p.Arg124Gln Single submitter ⚠
- p.Arg141Cys Single submitter ⚠
- p.Arg141His Single submitter ⚠
- p.Arg154Cys Single submitter ⚠
- p.Arg159His Single submitter ⚠
- p.Arg43Gln Single submitter ⚠
- p.Asn175Ser Single submitter ⚠
- p.Asn68Ser Single submitter ⚠
- p.Asp138Asn Single submitter ⚠
- p.Cys171Arg Single submitter ⚠
- p.Cys64Ser Single submitter ⚠
- p.Gln26Lys Single submitter ⚠
- p.Glu3Lys Single submitter ⚠
- p.Gly128Arg Single submitter ⚠
- p.Gly128Trp Single submitter ⚠
- p.Gly63Ser Single submitter ⚠
- p.Gly9Ala Single submitter ⚠
- p.Met13Ile Single submitter ⚠
- p.Met25Thr Single submitter ⚠
- p.Met25Val Single submitter ⚠
- p.Met27Ile Single submitter ⚠
- p.Phe54Leu Single submitter ⚠
- p.Pro148Arg Single submitter ⚠
- p.Ser164Ala Single submitter
- p.Ser165Pro Single submitter ⚠
- p.Ser174Asn Single submitter ⚠
- p.Trp84Arg Single submitter ⚠
- p.Val172Asp Single submitter ⚠
- p.Val172Ile Single submitter ⚠
- p.Val172Phe Single submitter ⚠