TMEM33 — 33 ClinVar variants
All ClinVar germline TMEM33 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
33 Uncertain significance
Full TMEM33 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TMEM33 p.Ala12Gly Uncertain significance Single submitter
- TMEM33 p.Ala12Val Uncertain significance Single submitter
- TMEM33 p.Ala133Ser Uncertain significance Single submitter
- TMEM33 p.Ala58Thr Uncertain significance Single submitter
- TMEM33 p.Ala82Thr Uncertain significance Single submitter
- TMEM33 p.Asn209Ser Uncertain significance Single submitter
- TMEM33 p.Asn7Lys Uncertain significance Single submitter
- TMEM33 p.Gln10His Uncertain significance Single submitter
- TMEM33 p.Gln10Lys Uncertain significance Single submitter
- TMEM33 p.Ile239Met Uncertain significance Single submitter
- TMEM33 p.Ile239Val Uncertain significance Single submitter
- TMEM33 p.Leu29Arg Uncertain significance Single submitter
- TMEM33 p.Met18Val Uncertain significance Single submitter
- TMEM33 p.Met27Ile Uncertain significance Single submitter
- TMEM33 p.Phe191Leu Uncertain significance Single submitter
- TMEM33 p.Pro9Ser Uncertain significance Single submitter
- TMEM33 p.Ser38Phe Uncertain significance Single submitter
- TMEM33 p.Thr127Lys Uncertain significance Single submitter
- TMEM33 p.Thr25Met Uncertain significance Single submitter
- TMEM33 p.Tyr188Cys Uncertain significance Single submitter
- TMEM33 p.Val130Ile Uncertain significance Single submitter
- TMEM33 p.Val35Ala Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- TMEM33 p.Arg199Gln Uncertain significance Single submitter
- TMEM33 p.Leu146Ser Uncertain significance Single submitter
- TMEM33 p.Leu45Pro Uncertain significance Single submitter
- TMEM33 p.Phe17Leu Uncertain significance Single submitter
- TMEM33 p.Ser197Leu Uncertain significance Single submitter
- TMEM33 p.Thr109Ala Uncertain significance Single submitter
- TMEM33 p.Thr193Ile Uncertain significance Single submitter
- TMEM33 p.Thr34Ala Uncertain significance Single submitter
All TMEM33 variants
Uncertain significance 33
- p.Ala123Val Single submitter
- p.Ala12Gly Single submitter ⚠
- p.Ala12Val Single submitter ⚠
- p.Ala133Ser Single submitter ⚠
- p.Ala58Thr Single submitter ⚠
- p.Ala82Thr Single submitter ⚠
- p.Arg199Gln Single submitter ⚠
- p.Asn209Ser Single submitter ⚠
- p.Asn7Lys Single submitter ⚠
- p.Gln10His Single submitter ⚠
- p.Gln10Lys Single submitter ⚠
- p.Ile239Met Single submitter ⚠
- p.Ile239Val Single submitter ⚠
- p.Leu146Ser Single submitter ⚠
- p.Leu29Arg Single submitter ⚠
- p.Leu45Pro Single submitter ⚠
- p.Met18Val Single submitter ⚠
- p.Met19Ile Single submitter
- p.Met27Ile Single submitter ⚠
- p.Phe17Leu Single submitter ⚠
- p.Phe191Leu Single submitter ⚠
- p.Pro9Ser Single submitter ⚠
- p.Ser197Leu Single submitter ⚠
- p.Ser38Phe Single submitter ⚠
- p.Thr109Ala Single submitter ⚠
- p.Thr127Lys Single submitter ⚠
- p.Thr127Met Single submitter
- p.Thr193Ile Single submitter ⚠
- p.Thr25Met Single submitter ⚠
- p.Thr34Ala Single submitter ⚠
- p.Tyr188Cys Single submitter ⚠
- p.Val130Ile Single submitter ⚠
- p.Val35Ala Single submitter ⚠