TMEM97 — 17 ClinVar variants
All ClinVar germline TMEM97 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
1 Likely benign · 16 Uncertain significance
Full TMEM97 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TMEM97 p.Arg36Gly Uncertain significance Single submitter
- TMEM97 p.Arg36Leu Uncertain significance Single submitter
- TMEM97 p.Arg7Lys Uncertain significance Single submitter
- TMEM97 p.Asp122Asn Uncertain significance Single submitter
- TMEM97 p.Gln60Arg Uncertain significance Single submitter
- TMEM97 p.Ile96Val Uncertain significance Single submitter
- TMEM97 p.Leu89Ile Uncertain significance Single submitter
- TMEM97 p.Met161Lys Uncertain significance Single submitter
- TMEM97 p.Pro113Ser Uncertain significance Single submitter
- TMEM97 p.Pro165Ser Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All TMEM97 variants
Likely benign 1
- p.Leu137Phe Single submitter
Uncertain significance 16
- p.Arg140Gln Single submitter ⚠
- p.Arg36Gly Single submitter ⚠
- p.Arg36Leu Single submitter ⚠
- p.Arg7Lys Single submitter ⚠
- p.Asp122Asn Single submitter ⚠
- p.Gln60Arg Single submitter ⚠
- p.Ile96Val Single submitter ⚠
- p.Leu89Ile Single submitter ⚠
- p.Met161Lys Single submitter ⚠
- p.Phe118Cys Single submitter
- p.Pro113Ser Single submitter ⚠
- p.Pro165Ser Single submitter ⚠
- p.Pro57Ser Single submitter ⚠
- p.Pro63Ser Single submitter ⚠
- p.Thr85Met Single submitter ⚠
- p.Trp49Cys Single submitter ⚠