TMPRSS11D — 52 ClinVar variants
All ClinVar germline TMPRSS11D variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
5 Likely benign · 47 Uncertain significance
Full TMPRSS11D gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TMPRSS11D p.Ala274Gly Uncertain significance Single submitter
- TMPRSS11D p.Ala306Pro Uncertain significance Single submitter
- TMPRSS11D p.Ala313Thr Uncertain significance Single submitter
- TMPRSS11D p.Ala42Gly Uncertain significance Single submitter
- TMPRSS11D p.Arg113Thr Uncertain significance Single submitter
- TMPRSS11D p.Arg186Thr Uncertain significance Single submitter
- TMPRSS11D p.Arg236His Uncertain significance Single submitter
- TMPRSS11D p.Arg6Pro Uncertain significance Single submitter
- TMPRSS11D p.Asn127Ser Uncertain significance Single submitter
- TMPRSS11D p.Asn218Asp Uncertain significance Single submitter
- TMPRSS11D p.Asn262Asp Uncertain significance Single submitter
- TMPRSS11D p.Glu136Lys Uncertain significance Single submitter
- TMPRSS11D p.Glu195Asp Uncertain significance Single submitter
- TMPRSS11D p.Glu315Gln Uncertain significance Single submitter
- TMPRSS11D p.Glu60Asp Uncertain significance Single submitter
- TMPRSS11D p.Glu90Ala Uncertain significance Single submitter
- TMPRSS11D p.Glu90Lys Uncertain significance Single submitter
- TMPRSS11D p.Gly176Ser Uncertain significance Single submitter
- TMPRSS11D p.Ile260Thr Uncertain significance Single submitter
- TMPRSS11D p.Ile347Asn Uncertain significance Single submitter
- TMPRSS11D p.Leu348Ser Uncertain significance Single submitter
- TMPRSS11D p.Leu56Phe Uncertain significance Single submitter
- TMPRSS11D p.Leu76Ser Uncertain significance Single submitter
- TMPRSS11D p.Met142Ile Uncertain significance Single submitter
- TMPRSS11D p.Met220Val Uncertain significance Single submitter
- TMPRSS11D p.Pro153Arg Uncertain significance Single submitter
- TMPRSS11D p.Pro199Leu Uncertain significance Single submitter
- TMPRSS11D p.Pro340Ser Uncertain significance Single submitter
- TMPRSS11D p.Pro357Ser Uncertain significance Single submitter
- TMPRSS11D p.Ser183Thr Uncertain significance Single submitter
- TMPRSS11D p.Ser377Thr Uncertain significance Single submitter
- TMPRSS11D p.Thr191Ser Uncertain significance Single submitter
- TMPRSS11D p.Thr283Ile Uncertain significance Single submitter
- TMPRSS11D p.Thr406Ala Uncertain significance Single submitter
- TMPRSS11D p.Tyr264Cys Uncertain significance Single submitter
- TMPRSS11D p.Tyr2Cys Uncertain significance Single submitter
- TMPRSS11D p.Val24Ile Uncertain significance Single submitter
- TMPRSS11D p.Val361Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- TMPRSS11D p.Arg205Trp Uncertain significance Single submitter
- TMPRSS11D p.Arg378Trp Uncertain significance Single submitter
- TMPRSS11D p.Asn334His Uncertain significance Single submitter
- TMPRSS11D p.Glu81Asp Uncertain significance Single submitter
- TMPRSS11D p.Gly318Ala Uncertain significance Single submitter
- TMPRSS11D p.Pro396Leu Uncertain significance Single submitter
All TMPRSS11D variants
Likely benign 5
- p.His341Tyr Single submitter
- p.Ile170Thr Single submitter
- p.Ser110Asn Single submitter
- p.Thr123Ser Single submitter
- p.Val38Ile Single submitter
Uncertain significance 47
- p.Ala274Gly Single submitter ⚠
- p.Ala306Pro Single submitter ⚠
- p.Ala313Thr Single submitter ⚠
- p.Ala363Thr Single submitter
- p.Ala42Gly Single submitter ⚠
- p.Arg113Thr Single submitter ⚠
- p.Arg186Thr Single submitter ⚠
- p.Arg205Trp Single submitter ⚠
- p.Arg236His Single submitter ⚠
- p.Arg236Pro Single submitter
- p.Arg378Trp Single submitter ⚠
- p.Arg6Pro Single submitter ⚠
- p.Asn127Ser Single submitter ⚠
- p.Asn218Asp Single submitter ⚠
- p.Asn262Asp Single submitter ⚠
- p.Asn334His Single submitter ⚠
- p.Glu136Lys Single submitter ⚠
- p.Glu195Asp Single submitter ⚠
- p.Glu315Gln Single submitter ⚠
- p.Glu60Asp Single submitter ⚠
- p.Glu81Asp Single submitter ⚠
- p.Glu90Ala Single submitter ⚠
- p.Glu90Lys Single submitter ⚠
- p.Gly176Ser Single submitter ⚠
- p.Gly318Ala Single submitter ⚠
- p.Ile260Thr Single submitter ⚠
- p.Ile347Asn Single submitter ⚠
- p.Leu348Ser Single submitter ⚠
- p.Leu56Phe Single submitter ⚠
- p.Leu76Ser Single submitter ⚠
- p.Met142Ile Single submitter ⚠
- p.Met220Val Single submitter ⚠
- p.Pro153Arg Single submitter ⚠
- p.Pro199Leu Single submitter ⚠
- p.Pro340Ser Single submitter ⚠
- p.Pro357Ser Single submitter ⚠
- p.Pro396Leu Single submitter ⚠
- p.Ser183Thr Single submitter ⚠
- p.Ser377Thr Single submitter ⚠
- p.Thr191Ser Single submitter ⚠
- p.Thr241Lys Single submitter
- p.Thr283Ile Single submitter ⚠
- p.Thr406Ala Single submitter ⚠
- p.Tyr264Cys Single submitter ⚠
- p.Tyr2Cys Single submitter ⚠
- p.Val24Ile Single submitter ⚠
- p.Val361Met Single submitter ⚠