TMPRSS4 — 65 ClinVar variants
All ClinVar germline TMPRSS4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
9 Likely benign · 56 Uncertain significance
Full TMPRSS4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TMPRSS4 p.Ala44Thr Uncertain significance Single submitter
- TMPRSS4 p.Arg110Gln Uncertain significance Single submitter
- TMPRSS4 p.Arg23Cys Uncertain significance Single submitter
- TMPRSS4 p.Arg355Leu Uncertain significance Single submitter
- TMPRSS4 p.Asp129Asn Uncertain significance Single submitter
- TMPRSS4 p.Asp252Asn Uncertain significance Single submitter
- TMPRSS4 p.Asp381Val Uncertain significance Single submitter
- TMPRSS4 p.Asp4Asn Uncertain significance Single submitter
- TMPRSS4 p.Cys140Tyr Uncertain significance Single submitter
- TMPRSS4 p.Cys410Tyr Uncertain significance Single submitter
- TMPRSS4 p.Cys83Ser Uncertain significance Single submitter
- TMPRSS4 p.Glu365Asp Uncertain significance Single submitter
- TMPRSS4 p.Glu90Asp Uncertain significance Single submitter
- TMPRSS4 p.Gly266Val Uncertain significance Single submitter
- TMPRSS4 p.Gly388Arg Uncertain significance Single submitter
- TMPRSS4 p.Gly388Cys Uncertain significance Single submitter
- TMPRSS4 p.His250Arg Uncertain significance Single submitter
- TMPRSS4 p.His250Tyr Uncertain significance Single submitter
- TMPRSS4 p.His91Gln Uncertain significance Single submitter
- TMPRSS4 p.Ile234Asn Uncertain significance Single submitter
- TMPRSS4 p.Leu41Val Uncertain significance Single submitter
- TMPRSS4 p.Phe96Leu Uncertain significance Single submitter
- TMPRSS4 p.Pro182Ala Uncertain significance Single submitter
- TMPRSS4 p.Pro182Ser Uncertain significance Single submitter
- TMPRSS4 p.Pro203Arg Uncertain significance Single submitter
- TMPRSS4 p.Ser125Tyr Uncertain significance Single submitter
- TMPRSS4 p.Ser190Pro Uncertain significance Single submitter
- TMPRSS4 p.Val165Ala Uncertain significance Single submitter
- TMPRSS4 p.Val350Ile Uncertain significance Single submitter
- TMPRSS4 p.Val432Ile Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- TMPRSS4 p.Ala292Thr Uncertain significance Single submitter
- TMPRSS4 p.Ala361Val Uncertain significance Single submitter
- TMPRSS4 p.Ala373Val Uncertain significance Single submitter
- TMPRSS4 p.Arg105His Uncertain significance Single submitter
- TMPRSS4 p.Arg20Cys Uncertain significance Single submitter
- TMPRSS4 p.Arg307Gly Uncertain significance Single submitter
- TMPRSS4 p.Asn335His Uncertain significance Single submitter
- TMPRSS4 p.Asp58Gly Uncertain significance Single submitter
- TMPRSS4 p.Gly388Ser Uncertain significance Single submitter
- TMPRSS4 p.Gly407Asp Uncertain significance Single submitter
- TMPRSS4 p.Gly417Glu Uncertain significance Single submitter
- TMPRSS4 p.Gly79Arg Uncertain significance Single submitter
- TMPRSS4 p.His399Pro Uncertain significance Single submitter
- TMPRSS4 p.Ile38Met Uncertain significance Single submitter
- TMPRSS4 p.Leu52Phe Uncertain significance Single submitter
- TMPRSS4 p.Lys201Glu Uncertain significance Single submitter
- TMPRSS4 p.Lys257Asn Uncertain significance Single submitter
- TMPRSS4 p.Pro158Arg Uncertain significance Single submitter
- TMPRSS4 p.Pro18Leu Uncertain significance Single submitter
- TMPRSS4 p.Pro72Leu Uncertain significance Single submitter
- TMPRSS4 p.Ser395Phe Uncertain significance Single submitter
- TMPRSS4 p.Thr420Ile Uncertain significance Single submitter
- TMPRSS4 p.Val220Ile Uncertain significance Single submitter
- TMPRSS4 p.Val380Gly Uncertain significance Single submitter
- TMPRSS4 p.Val404Ile Uncertain significance Single submitter
- TMPRSS4 p.Val432Ala Uncertain significance Single submitter
All TMPRSS4 variants
Likely benign 9
- p.Ala44Val Multiple submitters
- c.1010-2A>G Single submitter
- p.Arg175His Single submitter
- p.Asp225Asn Single submitter
- p.Asp359Glu Single submitter
- p.Cys193Ser Single submitter
- p.Ile278Val Single submitter
- p.Met294Val Single submitter
- p.Val229Ile Single submitter
Uncertain significance 56
- p.Ala292Thr Single submitter ⚠
- p.Ala361Val Single submitter ⚠
- p.Ala373Val Single submitter ⚠
- p.Ala44Thr Single submitter ⚠
- p.Arg105His Single submitter ⚠
- p.Arg110Gln Single submitter ⚠
- p.Arg20Cys Single submitter ⚠
- p.Arg23Cys Single submitter ⚠
- p.Arg307Gly Single submitter ⚠
- p.Arg355Leu Single submitter ⚠
- p.Asn335His Single submitter ⚠
- p.Asp129Asn Single submitter ⚠
- p.Asp252Asn Single submitter ⚠
- p.Asp381Val Single submitter ⚠
- p.Asp4Asn Single submitter ⚠
- p.Asp58Gly Single submitter ⚠
- p.Cys140Tyr Single submitter ⚠
- p.Cys410Tyr Single submitter ⚠
- p.Cys83Ser Single submitter ⚠
- p.Glu365Asp Single submitter ⚠
- p.Glu90Asp Single submitter ⚠
- p.Gly266Val Single submitter ⚠
- p.Gly388Arg Single submitter ⚠
- p.Gly388Cys Single submitter ⚠
- p.Gly388Ser Single submitter ⚠
- p.Gly407Asp Single submitter ⚠
- p.Gly417Glu Single submitter ⚠
- p.Gly79Arg Single submitter ⚠
- p.His250Arg Single submitter ⚠
- p.His250Tyr Single submitter ⚠
- p.His399Pro Single submitter ⚠
- p.His91Gln Single submitter ⚠
- p.Ile234Asn Single submitter ⚠
- p.Ile38Met Single submitter ⚠
- p.Leu41Val Single submitter ⚠
- p.Leu52Phe Single submitter ⚠
- p.Lys201Glu Single submitter ⚠
- p.Lys257Asn Single submitter ⚠
- p.Phe96Leu Single submitter ⚠
- p.Pro158Arg Single submitter ⚠
- p.Pro182Ala Single submitter ⚠
- p.Pro182Ser Single submitter ⚠
- p.Pro18Leu Single submitter ⚠
- p.Pro203Arg Single submitter ⚠
- p.Pro72Leu Single submitter ⚠
- p.Ser125Tyr Single submitter ⚠
- p.Ser190Pro Single submitter ⚠
- p.Ser395Phe Single submitter ⚠
- p.Thr420Ile Single submitter ⚠
- p.Val165Ala Single submitter ⚠
- p.Val220Ile Single submitter ⚠
- p.Val350Ile Single submitter ⚠
- p.Val380Gly Single submitter ⚠
- p.Val404Ile Single submitter ⚠
- p.Val432Ala Single submitter ⚠
- p.Val432Ile Single submitter ⚠