TNF — 16 ClinVar variants
All ClinVar germline TNF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
1 Pathogenic · 1 Benign · 1 Benign/Likely benign · 4 Likely benign · 9 Uncertain significance
Full TNF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
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TNF p.Arg108Trp
Pathogenic
No assertion criteria
TNF receptor binding, altered
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 5
The independent predictors disagree with each other — read with care.
- TNF p.Gly184Arg Uncertain significance Single submitter
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TNF p.Gly54Glu
Uncertain significance
Single submitter
Increased circulating interleukin 6 concentration
-
TNF p.Met6Lys
Uncertain significance
Single submitter
migraine with or without aura, susceptibility to, 1
-
TNF p.Thr83Asn
Uncertain significance
Single submitter
inherited susceptibility to asthma
- TNF p.Val117Ala Uncertain significance Single submitter
All TNF variants
Pathogenic 1
- p.Arg108Trp No assertion criteria TNF receptor binding, altered ⚠
Benign 1
- p.Arg29= Single submitter
Benign/Likely benign 1
- p.Pro84Leu Multiple submitters
Likely benign 4
Uncertain significance 9
- p.Arg107Leu Single submitter ⚠
- p.Asp66Asn Single submitter ⚠
- p.Gly184Arg Single submitter ⚠
- p.Gly54Glu Single submitter Increased circulating interleukin 6 concentration ⚠
- p.Gly57Ser Single submitter ⚠
- p.Met6Lys Single submitter migraine with or without aura, susceptibility to, 1 ⚠
- p.Thr83Asn Single submitter inherited susceptibility to asthma ⚠
- p.Val117Ala Single submitter ⚠
- p.Val41Leu Single submitter ⚠