Sugi Variant

Sugi Variant/TNFRSF9

TNFRSF9 — 200 ClinVar variants

All ClinVar germline TNFRSF9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →

9 Pathogenic · 2 Pathogenic/Likely pathogenic · 2 Likely pathogenic · 5 Conflicting · 10 Benign · 3 Benign/Likely benign · 82 Likely benign · 87 Uncertain significance

Full TNFRSF9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 67

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 3

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 50

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 14

The independent predictors disagree with each other — read with care.

All TNFRSF9 variants

Pathogenic 9

Pathogenic/Likely pathogenic 2

Likely pathogenic 2

Conflicting classifications of pathogenicity 5

Benign 10

Benign/Likely benign 3

Likely benign 82

Uncertain significance 87