TNFSF10 — 44 ClinVar variants
All ClinVar germline TNFSF10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
7 Benign · 3 Likely benign · 34 Uncertain significance
Full TNFSF10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TNFSF10 p.Arg115Thr Uncertain significance Single submitter
- TNFSF10 p.Arg149Cys Uncertain significance Single submitter
- TNFSF10 p.Arg149His Uncertain significance Single submitter
- TNFSF10 p.Arg149Leu Uncertain significance Single submitter
- TNFSF10 p.Arg85His Uncertain significance Single submitter
- TNFSF10 p.Asn152Lys Uncertain significance Single submitter
- TNFSF10 p.Asn253Ser Uncertain significance Single submitter
- TNFSF10 p.Asp203Glu Uncertain significance Single submitter
- TNFSF10 p.Glu178Gly Uncertain significance Single submitter
- TNFSF10 p.Glu60Gly Uncertain significance Single submitter
- TNFSF10 p.Gly180Arg Uncertain significance Single submitter
- TNFSF10 p.Gly53Ser Uncertain significance Single submitter
- TNFSF10 p.Gly9Ala Uncertain significance Single submitter
- TNFSF10 p.His168Arg Uncertain significance Single submitter
- TNFSF10 p.Ile242Val Uncertain significance Single submitter
- TNFSF10 p.Leu147Met Uncertain significance Single submitter
- TNFSF10 p.Lys145Thr Uncertain significance Single submitter
- TNFSF10 p.Lys197Arg Uncertain significance Single submitter
- TNFSF10 p.Ser28Thr Uncertain significance Single submitter
- TNFSF10 p.Ser50Phe Uncertain significance Single submitter
- TNFSF10 p.Ser50Pro Uncertain significance Single submitter
- TNFSF10 p.Thr15Asn Uncertain significance Single submitter
- TNFSF10 p.Tyr185Cys Uncertain significance Single submitter
- TNFSF10 p.Tyr189Asp Uncertain significance Single submitter
- TNFSF10 p.Tyr209His Uncertain significance Single submitter
- TNFSF10 p.Val103Ile Uncertain significance Single submitter
- TNFSF10 p.Val80Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TNFSF10 p.Ala272Thr Uncertain significance Single submitter
- TNFSF10 p.Ala277Ser Uncertain significance Single submitter
- TNFSF10 p.Ile184Leu Uncertain significance Single submitter
- TNFSF10 p.Ile242Met Uncertain significance Single submitter
- TNFSF10 p.Phe38Leu Uncertain significance Single submitter
- TNFSF10 p.Pro217Leu Uncertain significance Single submitter
- TNFSF10 p.Val260Ala Uncertain significance Single submitter
All TNFSF10 variants
Benign 7
- c.132+44A>C Multiple submitters
- c.133-3652A>C Multiple submitters
- c.314-88G>A Multiple submitters
- c.*207G>A Multiple submitters
- p.Phe275= Multiple submitters
- p.Tyr35= Multiple submitters
- p.Val33Ile Multiple submitters
Likely benign 3
- p.Ile110Thr Single submitter
- p.Leu87= Single submitter
- p.Val88Ile Single submitter
Uncertain significance 34
- p.Ala272Thr Single submitter ⚠
- p.Ala277Ser Single submitter ⚠
- p.Arg115Thr Single submitter ⚠
- p.Arg149Cys Single submitter ⚠
- p.Arg149His Single submitter ⚠
- p.Arg149Leu Single submitter ⚠
- p.Arg85His Single submitter ⚠
- p.Asn152Lys Single submitter ⚠
- p.Asn253Ser Single submitter ⚠
- p.Asp203Glu Single submitter ⚠
- p.Glu178Gly Single submitter ⚠
- p.Glu60Gly Single submitter ⚠
- p.Gly180Arg Single submitter ⚠
- p.Gly53Ser Single submitter ⚠
- p.Gly9Ala Single submitter ⚠
- p.His168Arg Single submitter ⚠
- p.Ile184Leu Single submitter ⚠
- p.Ile242Met Single submitter ⚠
- p.Ile242Val Single submitter ⚠
- p.Leu147Met Single submitter ⚠
- p.Lys145Thr Single submitter ⚠
- p.Lys197Arg Single submitter ⚠
- p.Phe38Leu Single submitter ⚠
- p.Pro217Leu Single submitter ⚠
- p.Ser28Thr Single submitter ⚠
- p.Ser50Phe Single submitter ⚠
- p.Ser50Pro Single submitter ⚠
- p.Thr15Asn Single submitter ⚠
- p.Tyr185Cys Single submitter ⚠
- p.Tyr189Asp Single submitter ⚠
- p.Tyr209His Single submitter ⚠
- p.Val103Ile Single submitter ⚠
- p.Val260Ala Single submitter ⚠
- p.Val80Ile Single submitter ⚠