Sugi Variant

Sugi Variant/TNK2

TNK2 — 492 ClinVar variants

All ClinVar germline TNK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 282 flagged for review →

1 Pathogenic · 10 Conflicting · 43 Benign · 6 Benign/Likely benign · 111 Likely benign · 321 Uncertain significance

Full TNK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 282

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 6

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 236

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 236

Predictors split 40

The independent predictors disagree with each other — read with care.

All TNK2 variants

Pathogenic 1

  • p.Arg352Trp No assertion criteria Epileptic encephalopathy

Conflicting classifications of pathogenicity 10

Benign 43

Benign/Likely benign 6

Likely benign 111

Uncertain significance 321

Showing the top 300 by review status; the full set is in the sitemap.