TNKS — 176 ClinVar variants
All ClinVar germline TNKS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 160 flagged for review →
6 Benign · 1 Benign/Likely benign · 4 Likely benign · 165 Uncertain significance
Full TNKS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 160
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 122
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TNKS p.Ala1000Thr Uncertain significance Single submitter
- TNKS p.Ala1007Ser Uncertain significance Single submitter
- TNKS p.Ala1015Val Uncertain significance Single submitter
- TNKS p.Ala107Ser Uncertain significance Single submitter
- TNKS p.Ala107Val Uncertain significance Single submitter
- TNKS p.Ala117Thr Uncertain significance Single submitter
- TNKS p.Ala1320Thr Uncertain significance Single submitter
- TNKS p.Ala21Thr Uncertain significance Single submitter
- TNKS p.Ala21Val Uncertain significance Single submitter
- TNKS p.Ala24Val Uncertain significance Single submitter
- TNKS p.Ala3Glu Uncertain significance Single submitter
- TNKS p.Ala426Pro Uncertain significance Single submitter
- TNKS p.Ala510Thr Uncertain significance Single submitter
- TNKS p.Ala599Ser Uncertain significance Single submitter
- TNKS p.Ala810Val Uncertain significance Single submitter
- TNKS p.Ala853Gly Uncertain significance Single submitter
- TNKS p.Ala960Val Uncertain significance Single submitter
- TNKS p.Ala969Ser Uncertain significance Single submitter
- TNKS p.Arg1019Lys Uncertain significance Single submitter
- TNKS p.Arg1149Gln Uncertain significance Single submitter
- TNKS p.Arg1253Thr Uncertain significance Single submitter
- TNKS p.Arg197Leu Uncertain significance Single submitter
- TNKS p.Arg245Cys Uncertain significance Single submitter
- TNKS p.Arg311Gln Uncertain significance Single submitter
- TNKS p.Arg383Gln Uncertain significance Single submitter
- TNKS p.Arg537His Uncertain significance Single submitter
- TNKS p.Arg60Gly Uncertain significance Single submitter
- TNKS p.Arg77Lys Uncertain significance Single submitter
- TNKS p.Asn1146Ser Uncertain significance Single submitter
- TNKS p.Asn1178Ser Uncertain significance Single submitter
- TNKS p.Asn309Ser Uncertain significance Single submitter
- TNKS p.Asn632Ser Uncertain significance Single submitter
- TNKS p.Asp460His Uncertain significance Single submitter
- TNKS p.Asp69Asn Uncertain significance Single submitter
- TNKS p.Asp69Gly Uncertain significance Single submitter
- TNKS p.Cys1163Tyr Uncertain significance Single submitter
- TNKS p.Cys97Tyr Uncertain significance Single submitter
- TNKS p.Gln237His Uncertain significance Single submitter
- TNKS p.Gln386Glu Uncertain significance Single submitter
- TNKS p.Gln390Arg Uncertain significance Single submitter
- TNKS p.Glu826Gly Uncertain significance Single submitter
- TNKS p.Gly1022Arg Uncertain significance Single submitter
- TNKS p.Gly158Arg Uncertain significance Single submitter
- TNKS p.Gly181Ala Uncertain significance Single submitter
- TNKS p.Gly23Arg Uncertain significance Single submitter
- TNKS p.Gly305Arg Uncertain significance Single submitter
- TNKS p.Gly346Asp Uncertain significance Single submitter
- TNKS p.Gly42Arg Uncertain significance Single submitter
- TNKS p.Gly52Ser Uncertain significance Single submitter
- TNKS p.Gly68Trp Uncertain significance Single submitter
- TNKS p.Gly707Ala Uncertain significance Single submitter
- TNKS p.Gly926Ser Uncertain significance Single submitter
- TNKS p.His10Gln Uncertain significance Single submitter
- TNKS p.His570Arg Uncertain significance Single submitter
- TNKS p.His578Tyr Uncertain significance Single submitter
- TNKS p.His61Tyr Uncertain significance Single submitter
- TNKS p.His711Arg Uncertain significance Single submitter
- TNKS p.His9Gln Uncertain significance Single submitter
- TNKS p.Ile1244Val Uncertain significance Single submitter
- TNKS p.Ile1279Thr Uncertain significance Single submitter
- TNKS p.Ile299Val Uncertain significance Single submitter
- TNKS p.Leu35Val Uncertain significance Single submitter
- TNKS p.Leu388Val Uncertain significance Single submitter
- TNKS p.Leu65Pro Uncertain significance Single submitter
- TNKS p.Leu768Ile Uncertain significance Single submitter
- TNKS p.Leu889Met Uncertain significance Single submitter
- TNKS p.Lys1020Arg Uncertain significance Single submitter
- TNKS p.Lys1036Thr Uncertain significance Single submitter
- TNKS p.Lys1157Arg Uncertain significance Single submitter
- TNKS p.Lys1326Asn Uncertain significance Single submitter
- TNKS p.Lys547Glu Uncertain significance Single submitter
- TNKS p.Met584Leu Uncertain significance Single submitter
- TNKS p.Met584Val Uncertain significance Single submitter
- TNKS p.Phe1099Tyr Uncertain significance Single submitter
- TNKS p.Phe56Val Uncertain significance Single submitter
- TNKS p.Pro120Ala Uncertain significance Single submitter
- TNKS p.Pro143Ala Uncertain significance Single submitter
- TNKS p.Pro20Ala Uncertain significance Single submitter
- TNKS p.Pro20Leu Uncertain significance Single submitter
- TNKS p.Pro22Ala Uncertain significance Single submitter
- TNKS p.Pro27Ser Uncertain significance Single submitter
- TNKS p.Pro285Ser Uncertain significance Single submitter
- TNKS p.Pro32Leu Uncertain significance Single submitter
- TNKS p.Pro34Gln Uncertain significance Single submitter
- TNKS p.Pro372Ser Uncertain significance Single submitter
- TNKS p.Pro37Leu Uncertain significance Single submitter
- TNKS p.Pro41Leu Uncertain significance Single submitter
- TNKS p.Pro41Ser Uncertain significance Single submitter
- TNKS p.Pro519Leu Uncertain significance Single submitter
- TNKS p.Pro55Leu Uncertain significance Single submitter
- TNKS p.Pro81Ala Uncertain significance Single submitter
- TNKS p.Pro825Leu Uncertain significance Single submitter
- TNKS p.Pro958Ser Uncertain significance Single submitter
- TNKS p.Pro983Leu Uncertain significance Single submitter
- TNKS p.Ser142Pro Uncertain significance Single submitter
- TNKS p.Ser149Arg Uncertain significance Single submitter
- TNKS p.Ser153Asn Uncertain significance Single submitter
- TNKS p.Ser161Gly Uncertain significance Single submitter
- TNKS p.Ser196Cys Uncertain significance Single submitter
- TNKS p.Ser36Thr Uncertain significance Single submitter
- TNKS p.Ser58Ala Uncertain significance Single submitter
- TNKS p.Ser58Cys Uncertain significance Single submitter
- TNKS p.Ser58Pro Uncertain significance Single submitter
- TNKS p.Ser671Thr Uncertain significance Single submitter
- TNKS p.Ser80Phe Uncertain significance Single submitter
- TNKS p.Ser91Gly Uncertain significance Single submitter
- TNKS p.Ser973Gly Uncertain significance Single submitter
- TNKS p.Thr1098Ser Uncertain significance Single submitter
- TNKS p.Thr1106Met Uncertain significance Single submitter
- TNKS p.Thr462Ile Uncertain significance Single submitter
- TNKS p.Thr905Ile Uncertain significance Single submitter
- TNKS p.Thr916Met Uncertain significance Single submitter
- TNKS p.Thr92Ala Uncertain significance Single submitter
- TNKS p.Thr93Ser Uncertain significance Single submitter
- TNKS p.Tyr1213Cys Uncertain significance Single submitter
- TNKS p.Tyr730Ser Uncertain significance Single submitter
- TNKS p.Val1004Ile Uncertain significance Single submitter
- TNKS p.Val1004Leu Uncertain significance Single submitter
- TNKS p.Val105Phe Uncertain significance Single submitter
- TNKS p.Val202Ala Uncertain significance Single submitter
- TNKS p.Val697Met Uncertain significance Single submitter
- TNKS p.Val99Gly Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- TNKS p.Ala289Gly Uncertain significance Single submitter
- TNKS p.Ala353Asp Uncertain significance Single submitter
- TNKS p.Arg200Thr Uncertain significance Single submitter
- TNKS p.Arg278Ser Uncertain significance Single submitter
- TNKS p.Arg537Cys Uncertain significance Single submitter
- TNKS p.Arg5Cys Uncertain significance Single submitter
- TNKS p.Arg5His Uncertain significance Single submitter
- TNKS p.Arg653Leu Uncertain significance Single submitter
- TNKS p.Asn1190Asp Uncertain significance Single submitter
- TNKS p.Asn849Lys Uncertain significance Single submitter
- TNKS p.Asp862Glu Uncertain significance Single submitter
- TNKS p.Cys1101Arg Uncertain significance Single submitter
- TNKS p.Gln592His Uncertain significance Single submitter
- TNKS p.Gly1088Asp Uncertain significance Single submitter
- TNKS p.His1132Arg Uncertain significance Single submitter
- TNKS p.His11Arg Uncertain significance Single submitter
- TNKS p.His11Tyr Uncertain significance Single submitter
- TNKS p.His12Tyr Uncertain significance Single submitter
- TNKS p.His391Leu Uncertain significance Single submitter
- TNKS p.Ile1189Thr Uncertain significance Single submitter
- TNKS p.Ile1193Met Uncertain significance Single submitter
- TNKS p.Leu1256Val Uncertain significance Single submitter
- TNKS p.Lys1156Asn Uncertain significance Single submitter
- TNKS p.Met1266Thr Uncertain significance Single submitter
- TNKS p.Pro1282Leu Uncertain significance Single submitter
- TNKS p.Pro617Leu Uncertain significance Single submitter
- TNKS p.Ser266Arg Uncertain significance Single submitter
- TNKS p.Ser742Phe Uncertain significance Single submitter
- TNKS p.Ser80Tyr Uncertain significance Single submitter
- TNKS p.Ser991Cys Uncertain significance Single submitter
- TNKS p.Thr1255Ile Uncertain significance Single submitter
- TNKS p.Thr371Ser Uncertain significance Single submitter
- TNKS p.Thr665Asn Uncertain significance Single submitter
- TNKS p.Thr665Ile Uncertain significance Single submitter
- TNKS p.Thr795Arg Uncertain significance Single submitter
- TNKS p.Thr938Ala Uncertain significance Single submitter
- TNKS p.Thr938Met Uncertain significance Single submitter
- TNKS p.Tyr415Ser Uncertain significance Single submitter
All TNKS variants
Benign 6
- c.1456+4C>T Multiple submitters
- c.674-5T>C Multiple submitters
- p.Pro983= Multiple submitters
- p.Ser148= Multiple submitters
- p.Glu349= Single submitter
- p.Thr95= Single submitter
Benign/Likely benign 1
- p.Thr777= Multiple submitters
Likely benign 4
- p.Ala1025Thr Single submitter
- p.Ala1271= Single submitter
- p.Gly86Ser Single submitter
- p.His304= Single submitter
Uncertain significance 165
- p.Ala1000Thr Single submitter ⚠
- p.Ala1007Ser Single submitter ⚠
- p.Ala1015Val Single submitter ⚠
- p.Ala107Ser Single submitter ⚠
- p.Ala107Val Single submitter ⚠
- p.Ala117Thr Single submitter ⚠
- p.Ala1320Thr Single submitter ⚠
- p.Ala21Thr Single submitter ⚠
- p.Ala21Val Single submitter ⚠
- p.Ala24Val Single submitter ⚠
- p.Ala289Gly Single submitter ⚠
- p.Ala353Asp Single submitter ⚠
- p.Ala3Glu Single submitter ⚠
- p.Ala426Pro Single submitter ⚠
- p.Ala510Thr Single submitter ⚠
- p.Ala599Ser Single submitter ⚠
- p.Ala810Val Single submitter ⚠
- p.Ala853Gly Single submitter ⚠
- p.Ala960Val Single submitter ⚠
- p.Ala969Ser Single submitter ⚠
- p.Arg1019Lys Single submitter ⚠
- p.Arg1149Gln Single submitter ⚠
- p.Arg1253Thr Single submitter ⚠
- p.Arg197Leu Single submitter ⚠
- p.Arg200Thr Single submitter ⚠
- p.Arg245Cys Single submitter ⚠
- p.Arg278Ser Single submitter ⚠
- p.Arg311Gln Single submitter ⚠
- p.Arg383Gln Single submitter ⚠
- p.Arg537Cys Single submitter ⚠
- p.Arg537His Single submitter ⚠
- p.Arg5Cys Single submitter ⚠
- p.Arg5His Single submitter ⚠
- p.Arg60Gly Single submitter ⚠
- p.Arg653Leu Single submitter ⚠
- p.Arg77Lys Single submitter ⚠
- p.Asn1146Ser Single submitter ⚠
- p.Asn1178Ser Single submitter ⚠
- p.Asn1190Asp Single submitter ⚠
- p.Asn309Ser Single submitter ⚠
- p.Asn632Ser Single submitter ⚠
- p.Asn849Lys Single submitter ⚠
- p.Asp460His Single submitter ⚠
- p.Asp69Asn Single submitter ⚠
- p.Asp69Gly Single submitter ⚠
- p.Asp862Glu Single submitter ⚠
- p.Cys1101Arg Single submitter ⚠
- p.Cys1163Tyr Single submitter ⚠
- p.Cys97Tyr Single submitter ⚠
- p.Gln237His Single submitter ⚠
- p.Gln386Glu Single submitter ⚠
- p.Gln390Arg Single submitter ⚠
- p.Gln592His Single submitter ⚠
- p.Glu826Gly Single submitter ⚠
- p.Gly1022Arg Single submitter ⚠
- p.Gly1088Asp Single submitter ⚠
- p.Gly158Arg Single submitter ⚠
- p.Gly181Ala Single submitter ⚠
- p.Gly23Arg Single submitter ⚠
- p.Gly305Arg Single submitter ⚠
- p.Gly346Asp Single submitter ⚠
- p.Gly42Arg Single submitter ⚠
- p.Gly52Ser Single submitter ⚠
- p.Gly68Trp Single submitter ⚠
- p.Gly707Ala Single submitter ⚠
- p.Gly926Ser Single submitter ⚠
- p.His10Gln Single submitter ⚠
- p.His1132Arg Single submitter ⚠
- p.His11Arg Single submitter ⚠
- p.His11Tyr Single submitter ⚠
- p.His12Tyr Single submitter ⚠
- p.His391Leu Single submitter ⚠
- p.His570Arg Single submitter ⚠
- p.His578Tyr Single submitter ⚠
- p.His61Tyr Single submitter ⚠
- p.His711Arg Single submitter ⚠
- p.His9Gln Single submitter ⚠
- p.Ile1189Thr Single submitter ⚠
- p.Ile1193Met Single submitter ⚠
- p.Ile1244Val Single submitter ⚠
- p.Ile1279Thr Single submitter ⚠
- p.Ile295Asn Single submitter
- p.Ile299Val Single submitter ⚠
- p.Leu1256Val Single submitter ⚠
- p.Leu35Val Single submitter ⚠
- p.Leu388Val Single submitter ⚠
- p.Leu65Pro Single submitter ⚠
- p.Leu768Ile Single submitter ⚠
- p.Leu889Met Single submitter ⚠
- p.Lys1020Arg Single submitter ⚠
- p.Lys1036Thr Single submitter ⚠
- p.Lys1156Asn Single submitter ⚠
- p.Lys1157Arg Single submitter ⚠
- p.Lys1326Asn Single submitter ⚠
- p.Lys547Glu Single submitter ⚠
- p.Met1266Thr Single submitter ⚠
- p.Met584Leu Single submitter ⚠
- p.Met584Val Single submitter ⚠
- p.Met956Val Single submitter
- p.Phe1099Tyr Single submitter ⚠
- p.Phe56Val Single submitter ⚠
- p.Pro120Ala Single submitter ⚠
- p.Pro1235Ala Single submitter
- p.Pro1282Leu Single submitter ⚠
- p.Pro143Ala Single submitter ⚠
- p.Pro20Ala Single submitter ⚠
- p.Pro20Leu Single submitter ⚠
- p.Pro22Ala Single submitter ⚠
- p.Pro27Ser Single submitter ⚠
- p.Pro285Ser Single submitter ⚠
- p.Pro32Leu Single submitter ⚠
- p.Pro34Gln Single submitter ⚠
- p.Pro372Ser Single submitter ⚠
- p.Pro37Leu Single submitter ⚠
- p.Pro41Leu Single submitter ⚠
- p.Pro41Ser Single submitter ⚠
- p.Pro519Leu Single submitter ⚠
- p.Pro55Leu Single submitter ⚠
- p.Pro617Leu Single submitter ⚠
- p.Pro81Ala Single submitter ⚠
- p.Pro825Leu Single submitter ⚠
- p.Pro958Ser Single submitter ⚠
- p.Pro983Arg Single submitter
- p.Pro983Leu Single submitter ⚠
- p.Ser142Pro Single submitter ⚠
- p.Ser149Arg Single submitter ⚠
- p.Ser153Asn Single submitter ⚠
- p.Ser161Gly Single submitter ⚠
- p.Ser196Cys Single submitter ⚠
- p.Ser266Arg Single submitter ⚠
- p.Ser36Thr Single submitter ⚠
- p.Ser58Ala Single submitter ⚠
- p.Ser58Cys Single submitter ⚠
- p.Ser58Pro Single submitter ⚠
- p.Ser671Thr Single submitter ⚠
- p.Ser742Phe Single submitter ⚠
- p.Ser80Phe Single submitter ⚠
- p.Ser80Tyr Single submitter ⚠
- p.Ser91Gly Single submitter ⚠
- p.Ser973Gly Single submitter ⚠
- p.Ser991Cys Single submitter ⚠
- p.Thr1098Ser Single submitter ⚠
- p.Thr1106Met Single submitter ⚠
- p.Thr1255Ile Single submitter ⚠
- p.Thr371Ser Single submitter ⚠
- p.Thr462Ile Single submitter ⚠
- p.Thr665Asn Single submitter ⚠
- p.Thr665Ile Single submitter ⚠
- p.Thr785Ile Single submitter
- p.Thr795Arg Single submitter ⚠
- p.Thr905Ile Single submitter ⚠
- p.Thr916Met Single submitter ⚠
- p.Thr92Ala Single submitter ⚠
- p.Thr938Ala Single submitter ⚠
- p.Thr938Met Single submitter ⚠
- p.Thr93Ser Single submitter ⚠
- p.Tyr1213Cys Single submitter ⚠
- p.Tyr415Ser Single submitter ⚠
- p.Tyr730Ser Single submitter ⚠
- p.Val1004Ile Single submitter ⚠
- p.Val1004Leu Single submitter ⚠
- p.Val105Phe Single submitter ⚠
- p.Val202Ala Single submitter ⚠
- p.Val697Met Single submitter ⚠
- p.Val99Gly Single submitter ⚠