TNKS2 — 100 ClinVar variants

All ClinVar germline TNKS2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 89 flagged for review →

1 Conflicting · 4 Benign · 1 Likely benign · 94 Uncertain significance

Full TNKS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 89

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

TNKS2 p.Thr627Ile Conflicting Single submitter

Predictors lean, ClinVar uncertain 72

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 16

The independent predictors disagree with each other — read with care.

All TNKS2 variants

Conflicting classifications of pathogenicity 1

p.Thr627Ile Single submitter ⚠

Benign 4

c.1673+17G>A Multiple submitters
c.424+20C>T Multiple submitters
p.Leu825= Multiple submitters
c.1447+9T>G Single submitter

Likely benign 1

p.Gly558= Single submitter

Uncertain significance 94

p.Ala1135Val Single submitter
p.Ala1137Ser Single submitter ⚠
p.Ala239Gly Single submitter ⚠
p.Ala285Thr Single submitter
p.Ala327Thr Single submitter ⚠
p.Ala391Thr Single submitter ⚠
p.Ala492Thr Single submitter ⚠
p.Ala647Val Single submitter ⚠
p.Ala740Val Single submitter ⚠
p.Ala802Gly Single submitter ⚠
p.Ala837Thr Single submitter ⚠
p.Arg1012Gln Single submitter ⚠
p.Arg120Gln Single submitter ⚠
p.Arg153Gln Single submitter ⚠
p.Arg42Thr Single submitter ⚠
p.Arg673His Single submitter ⚠
p.Arg932Ser Single submitter ⚠
p.Arg991Ser Single submitter ⚠
p.Asn1002Lys Single submitter ⚠
p.Asn118Lys Single submitter ⚠
p.Asn310Ser Single submitter ⚠
p.Asn476Asp Single submitter ⚠
p.Asn813Ser Single submitter ⚠
p.Asn83Asp Single submitter ⚠
p.Asn918Ser Single submitter ⚠
p.Asn941Asp Single submitter ⚠
p.Asn993Ser Single submitter ⚠
p.Asp179Gly Single submitter
p.Asp789His Single submitter ⚠
p.Asp957His Single submitter ⚠
p.Asp957Tyr Single submitter ⚠
p.Gln471Arg Single submitter
p.Gln676His Single submitter ⚠
p.Gln810Glu Single submitter ⚠
p.Glu417Gln Single submitter ⚠
p.Glu483Asp Single submitter ⚠
p.Glu498Lys Single submitter ⚠
p.Glu543Gln Single submitter ⚠
p.Glu861Lys Single submitter ⚠
p.Glu888Lys Single submitter ⚠
p.Gly645Arg Single submitter ⚠
p.Gly723Arg Single submitter ⚠
p.Gly778Arg Single submitter ⚠
p.Gly81Asp Single submitter ⚠
p.Gly862Asp Single submitter ⚠
p.Gly91Ser Single submitter ⚠
p.Gly936Arg Single submitter
p.His129Pro Single submitter ⚠
p.His266Arg Single submitter ⚠
p.His350Leu Single submitter ⚠
p.His412Pro Single submitter ⚠
p.His701Arg Single submitter ⚠
p.His750Pro Single submitter ⚠
p.Ile1040Asn Single submitter ⚠
p.Ile1075Val Single submitter ⚠
p.Ile382Met Single submitter ⚠
p.Ile522Leu Single submitter ⚠
p.Ile522Val Single submitter ⚠
p.Ile927Val Single submitter ⚠
p.Ile93Val Single submitter ⚠
p.Ile988Leu Single submitter ⚠
p.Ile997Thr Single submitter ⚠
p.Leu481Phe Single submitter ⚠
p.Leu497Arg Single submitter ⚠
p.Leu560Phe Single submitter ⚠
p.Leu730Val Single submitter
p.Leu78His Single submitter ⚠
p.Leu866Ser Single submitter ⚠
p.Leu885Pro Single submitter ⚠
p.Leu946Phe Single submitter ⚠
p.Lys359Arg Single submitter ⚠
p.Met194Val Single submitter ⚠
p.Met273Val Single submitter ⚠
p.Met355Val Single submitter ⚠
p.Met798Ile Single submitter ⚠
p.Pro117His Single submitter ⚠
p.Pro127Ser Single submitter ⚠
p.Pro748Ser Single submitter ⚠
p.Pro829Gln Single submitter ⚠
p.Pro872Leu Single submitter ⚠
p.Pro94Ser Single submitter ⚠
p.Ser207Ile Single submitter ⚠
p.Ser830Pro Single submitter ⚠
p.Thr1102Ile Single submitter ⚠
p.Thr60Ile Single submitter ⚠
p.Thr741Met Single submitter ⚠
p.Thr795Ile Single submitter ⚠
p.Thr900Ser Single submitter ⚠
p.Tyr1073His Single submitter ⚠
p.Val517Ala Single submitter ⚠
p.Val541Met Single submitter ⚠
p.Val542Met Single submitter ⚠
p.Val882Ile Single submitter ⚠
p.Val903Ile Single submitter ⚠