Sugi Variant

Sugi Variant/TNNT1

TNNT1 — 401 ClinVar variants

All ClinVar germline TNNT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 110 flagged for review →

20 Pathogenic · 4 Pathogenic/Likely pathogenic · 10 Likely pathogenic · 15 Conflicting · 40 Benign · 7 Benign/Likely benign · 176 Likely benign · 129 Uncertain significance

Full TNNT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 110

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 76

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 33

The independent predictors disagree with each other — read with care.

All TNNT1 variants

Pathogenic 20

Pathogenic/Likely pathogenic 4

Likely pathogenic 10

Conflicting classifications of pathogenicity 15

Benign 40

Benign/Likely benign 7

Likely benign 176

Uncertain significance 129