TNS4 — 115 ClinVar variants
All ClinVar germline TNS4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 99 flagged for review →
1 Benign · 11 Likely benign · 103 Uncertain significance
Full TNS4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 99
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 87
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TNS4 p.Ala19Val Uncertain significance Single submitter
- TNS4 p.Ala525Thr Uncertain significance Single submitter
- TNS4 p.Ala698Asp Uncertain significance Single submitter
- TNS4 p.Ala74Val Uncertain significance Single submitter
- TNS4 p.Ala87Pro Uncertain significance Single submitter
- TNS4 p.Arg180His Uncertain significance Single submitter
- TNS4 p.Arg188Lys Uncertain significance Single submitter
- TNS4 p.Arg213His Uncertain significance Single submitter
- TNS4 p.Arg213Pro Uncertain significance Single submitter
- TNS4 p.Arg259Gln Uncertain significance Single submitter
- TNS4 p.Arg259Trp Uncertain significance Single submitter
- TNS4 p.Arg25Gly Uncertain significance Single submitter
- TNS4 p.Arg267Gln Uncertain significance Single submitter
- TNS4 p.Arg267Trp Uncertain significance Single submitter
- TNS4 p.Arg456Gln Uncertain significance Single submitter
- TNS4 p.Arg464Lys Uncertain significance Single submitter
- TNS4 p.Arg474Gly Uncertain significance Single submitter
- TNS4 p.Arg480Gln Uncertain significance Single submitter
- TNS4 p.Arg509Pro Uncertain significance Single submitter
- TNS4 p.Arg641Gln Uncertain significance Single submitter
- TNS4 p.Arg641Trp Uncertain significance Single submitter
- TNS4 p.Asn684Lys Uncertain significance Single submitter
- TNS4 p.Asp147Ala Uncertain significance Single submitter
- TNS4 p.Asp93Asn Uncertain significance Single submitter
- TNS4 p.Cys78Ser Uncertain significance Single submitter
- TNS4 p.Gln165Leu Uncertain significance Single submitter
- TNS4 p.Gln51Arg Uncertain significance Single submitter
- TNS4 p.Gln678Glu Uncertain significance Single submitter
- TNS4 p.Glu111Gln Uncertain significance Single submitter
- TNS4 p.Glu141Lys Uncertain significance Single submitter
- TNS4 p.Glu528Gln Uncertain significance Single submitter
- TNS4 p.Gly177Ser Uncertain significance Single submitter
- TNS4 p.Gly182Ala Uncertain significance Single submitter
- TNS4 p.Gly183Ala Uncertain significance Single submitter
- TNS4 p.Gly205Val Uncertain significance Single submitter
- TNS4 p.Gly208Ser Uncertain significance Single submitter
- TNS4 p.Gly210Arg Uncertain significance Single submitter
- TNS4 p.Gly484Ser Uncertain significance Single submitter
- TNS4 p.Gly501Asp Uncertain significance Single submitter
- TNS4 p.Gly597Arg Uncertain significance Single submitter
- TNS4 p.Gly89Arg Uncertain significance Single submitter
- TNS4 p.His166Asn Uncertain significance Single submitter
- TNS4 p.His583Tyr Uncertain significance Single submitter
- TNS4 p.Ile98Thr Uncertain significance Single submitter
- TNS4 p.Leu28Val Uncertain significance Single submitter
- TNS4 p.Lys637Gln Uncertain significance Single submitter
- TNS4 p.Met369Leu Uncertain significance Single submitter
- TNS4 p.Met435Thr Uncertain significance Single submitter
- TNS4 p.Met443Arg Uncertain significance Single submitter
- TNS4 p.Met654Thr Uncertain significance Single submitter
- TNS4 p.Phe471Ser Uncertain significance Single submitter
- TNS4 p.Pro114Ser Uncertain significance Single submitter
- TNS4 p.Pro121Ser Uncertain significance Single submitter
- TNS4 p.Pro20Ser Uncertain significance Single submitter
- TNS4 p.Pro229Ser Uncertain significance Single submitter
- TNS4 p.Pro249Leu Uncertain significance Single submitter
- TNS4 p.Pro345Arg Uncertain significance Single submitter
- TNS4 p.Pro345Thr Uncertain significance Single submitter
- TNS4 p.Pro383Ser Uncertain significance Single submitter
- TNS4 p.Pro428Thr Uncertain significance Single submitter
- TNS4 p.Pro63Ser Uncertain significance Single submitter
- TNS4 p.Pro81Leu Uncertain significance Single submitter
- TNS4 p.Pro91Ser Uncertain significance Single submitter
- TNS4 p.Ser143Phe Uncertain significance Single submitter
- TNS4 p.Ser196Arg Uncertain significance Single submitter
- TNS4 p.Ser197Ile Uncertain significance Single submitter
- TNS4 p.Ser306Thr Uncertain significance Single submitter
- TNS4 p.Ser315Ala Uncertain significance Single submitter
- TNS4 p.Ser322Leu Uncertain significance Single submitter
- TNS4 p.Ser350Phe Uncertain significance Single submitter
- TNS4 p.Ser359Asn Uncertain significance Single submitter
- TNS4 p.Ser359Ile Uncertain significance Single submitter
- TNS4 p.Ser504Arg Uncertain significance Single submitter
- TNS4 p.Thr173Asn Uncertain significance Single submitter
- TNS4 p.Thr366Ile Uncertain significance Single submitter
- TNS4 p.Thr391Asn Uncertain significance Single submitter
- TNS4 p.Thr445Ile Uncertain significance Single submitter
- TNS4 p.Thr45Met Uncertain significance Single submitter
- TNS4 p.Thr607Ile Uncertain significance Single submitter
- TNS4 p.Thr616Met Uncertain significance Single submitter
- TNS4 p.Thr648Asn Uncertain significance Single submitter
- TNS4 p.Trp449Ser Uncertain significance Single submitter
- TNS4 p.Trp661Arg Uncertain significance Single submitter
- TNS4 p.Tyr692His Uncertain significance Single submitter
- TNS4 p.Val538Met Uncertain significance Single submitter
- TNS4 p.Val601Met Uncertain significance Single submitter
- TNS4 p.Val72Met Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- TNS4 p.Arg509Gln Uncertain significance Single submitter
- TNS4 p.Arg659Gln Uncertain significance Single submitter
- TNS4 p.Asn106Tyr Uncertain significance Single submitter
- TNS4 p.Asp506Tyr Uncertain significance Single submitter
- TNS4 p.Glu466Lys Uncertain significance Single submitter
- TNS4 p.Glu593Gly Uncertain significance Single submitter
- TNS4 p.Gly532Glu Uncertain significance Single submitter
- TNS4 p.Ile148Lys Uncertain significance Single submitter
- TNS4 p.Lys440Asn Uncertain significance Single submitter
- TNS4 p.Pro373Ser Uncertain significance Single submitter
- TNS4 p.Ser248Tyr Uncertain significance Single submitter
- TNS4 p.Ser291Phe Uncertain significance Single submitter
All TNS4 variants
Benign 1
- p.Gly379Ser Multiple submitters
Likely benign 11
- p.Ala156Thr Single submitter
- p.Ala334Val Single submitter
- p.Ala432Ser Single submitter
- p.Ala432Thr Single submitter
- p.Gly64Asp Single submitter
- p.Ile271Val Single submitter
- p.Met135Thr Single submitter
- p.Phe79Leu Single submitter
- p.Pro500Ser Single submitter
- p.Ser241Leu Single submitter
- p.Val190Ile Single submitter
Uncertain significance 103
- p.Ala19Val Single submitter ⚠
- p.Ala525Thr Single submitter ⚠
- p.Ala690Val Single submitter
- p.Ala698Asp Single submitter ⚠
- p.Ala74Val Single submitter ⚠
- p.Ala87Pro Single submitter ⚠
- p.Arg180His Single submitter ⚠
- p.Arg188Lys Single submitter ⚠
- p.Arg213His Single submitter ⚠
- p.Arg213Pro Single submitter ⚠
- p.Arg259Gln Single submitter ⚠
- p.Arg259Trp Single submitter ⚠
- p.Arg25Gly Single submitter ⚠
- p.Arg267Gln Single submitter ⚠
- p.Arg267Trp Single submitter ⚠
- p.Arg456Gln Single submitter ⚠
- p.Arg464Lys Single submitter ⚠
- p.Arg474Gly Single submitter ⚠
- p.Arg480Gln Single submitter ⚠
- p.Arg509Gln Single submitter ⚠
- p.Arg509Pro Single submitter ⚠
- p.Arg641Gln Single submitter ⚠
- p.Arg641Trp Single submitter ⚠
- p.Arg659Gln Single submitter ⚠
- p.Asn106Tyr Single submitter ⚠
- p.Asn684Lys Single submitter ⚠
- p.Asp147Ala Single submitter ⚠
- p.Asp506Tyr Single submitter ⚠
- p.Asp93Asn Single submitter ⚠
- p.Cys78Ser Single submitter ⚠
- p.Gln165Leu Single submitter ⚠
- p.Gln51Arg Single submitter ⚠
- p.Gln678Glu Single submitter ⚠
- p.Glu111Gln Single submitter ⚠
- p.Glu141Lys Single submitter ⚠
- p.Glu466Lys Single submitter ⚠
- p.Glu528Gln Single submitter ⚠
- p.Glu593Gly Single submitter ⚠
- p.Gly177Ser Single submitter ⚠
- p.Gly182Ala Single submitter ⚠
- p.Gly183Ala Single submitter ⚠
- p.Gly205Val Single submitter ⚠
- p.Gly208Ser Single submitter ⚠
- p.Gly210Arg Single submitter ⚠
- p.Gly484Ser Single submitter ⚠
- p.Gly501Asp Single submitter ⚠
- p.Gly532Glu Single submitter ⚠
- p.Gly597Arg Single submitter ⚠
- p.Gly89Arg Single submitter ⚠
- p.His166Asn Single submitter ⚠
- p.His521Gln Single submitter
- p.His583Tyr Single submitter ⚠
- p.Ile148Lys Single submitter ⚠
- p.Ile98Thr Single submitter ⚠
- p.Leu28Val Single submitter ⚠
- p.Lys440Asn Single submitter ⚠
- p.Lys637Gln Single submitter ⚠
- p.Met369Leu Single submitter ⚠
- p.Met435Thr Single submitter ⚠
- p.Met443Arg Single submitter ⚠
- p.Met654Thr Single submitter ⚠
- p.Phe471Ser Single submitter ⚠
- p.Pro114Ser Single submitter ⚠
- p.Pro121Ser Single submitter ⚠
- p.Pro20Ser Single submitter ⚠
- p.Pro229Ser Single submitter ⚠
- p.Pro249Leu Single submitter ⚠
- p.Pro345Arg Single submitter ⚠
- p.Pro345Thr Single submitter ⚠
- p.Pro373Ser Single submitter ⚠
- p.Pro383Ser Single submitter ⚠
- p.Pro428Thr Single submitter ⚠
- p.Pro63Ser Single submitter ⚠
- p.Pro81Leu Single submitter ⚠
- p.Pro91Ser Single submitter ⚠
- p.Ser143Phe Single submitter ⚠
- p.Ser196Arg Single submitter ⚠
- p.Ser197Ile Single submitter ⚠
- p.Ser248Tyr Single submitter ⚠
- p.Ser291Phe Single submitter ⚠
- p.Ser306Thr Single submitter ⚠
- p.Ser315Ala Single submitter ⚠
- p.Ser322Leu Single submitter ⚠
- p.Ser350Phe Single submitter ⚠
- p.Ser359Asn Single submitter ⚠
- p.Ser359Ile Single submitter ⚠
- p.Ser504Arg Single submitter ⚠
- p.Ser515Leu Single submitter
- p.Ser668Phe Single submitter
- p.Thr173Asn Single submitter ⚠
- p.Thr366Ile Single submitter ⚠
- p.Thr391Asn Single submitter ⚠
- p.Thr445Ile Single submitter ⚠
- p.Thr45Met Single submitter ⚠
- p.Thr607Ile Single submitter ⚠
- p.Thr616Met Single submitter ⚠
- p.Thr648Asn Single submitter ⚠
- p.Trp449Ser Single submitter ⚠
- p.Trp661Arg Single submitter ⚠
- p.Tyr692His Single submitter ⚠
- p.Val538Met Single submitter ⚠
- p.Val601Met Single submitter ⚠
- p.Val72Met Single submitter ⚠