TPX2 — 96 ClinVar variants

All ClinVar germline TPX2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →

3 Benign · 7 Likely benign · 86 Uncertain significance

Full TPX2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 87

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 52

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 35

The independent predictors disagree with each other — read with care.

All TPX2 variants

Benign 3

p.Ala184= Multiple submitters
p.Ser94= Multiple submitters
p.Lys439= Single submitter

Likely benign 7

p.Ala108Thr Single submitter
p.Asp333Ala Single submitter
p.Glu507Lys Single submitter
p.Ile431Val Single submitter
p.Leu238Phe Single submitter ⚠
p.Leu491= Single submitter
p.Phe262= Single submitter

Uncertain significance 86

p.Ala142Val Single submitter ⚠
p.Ala184Gly Single submitter ⚠
p.Ala668Val Single submitter ⚠
p.Ala683Pro Single submitter ⚠
p.Arg229Trp Single submitter ⚠
p.Arg267Gln Single submitter ⚠
p.Arg296Gln Single submitter ⚠
p.Arg337Gln Single submitter ⚠
p.Arg379Trp Single submitter ⚠
p.Arg440Ile Single submitter ⚠
p.Arg496Gln Single submitter ⚠
p.Arg543Gln Single submitter ⚠
p.Arg547His Single submitter ⚠
p.Arg671Trp Single submitter ⚠
p.Arg693Ile Single submitter ⚠
p.Arg693Thr Single submitter ⚠
p.Asn183Ser Single submitter ⚠
p.Asn18Asp Single submitter ⚠
p.Asn18Ser Single submitter ⚠
p.Asn308Lys Single submitter ⚠
p.Asn30Tyr Single submitter ⚠
p.Asn43Thr Single submitter ⚠
p.Asn89Asp Single submitter ⚠
p.Asp366Gly Single submitter ⚠
p.Cys100Arg Single submitter ⚠
p.Cys301Ser Single submitter ⚠
p.Cys536Arg Single submitter ⚠
p.Cys747Arg Single submitter ⚠
p.Gln127Arg Single submitter ⚠
p.Gln589Pro Single submitter ⚠
p.Gln657Arg Single submitter ⚠
p.Gln67Arg Single submitter ⚠
p.Glu212Asp Single submitter ⚠
p.Glu276Gly Single submitter ⚠
p.Glu277Val Single submitter ⚠
p.Glu475Lys Single submitter ⚠
p.Glu614Gly Single submitter ⚠
p.Glu615Asp Single submitter ⚠
p.Gly26Arg Single submitter ⚠
p.Gly57Asp Single submitter ⚠
p.His136Tyr Single submitter ⚠
p.His194Tyr Single submitter ⚠
p.His290Tyr Single submitter ⚠
p.His376Tyr Single submitter ⚠
p.Ile109Met Single submitter ⚠
p.Ile109Val Single submitter ⚠
p.Ile417Val Single submitter ⚠
p.Leu155Val Single submitter ⚠
p.Leu238Arg Single submitter ⚠
p.Leu344Met Single submitter ⚠
p.Leu412Phe Single submitter ⚠
p.Leu479Val Single submitter ⚠
p.Leu61Trp Single submitter ⚠
p.Lys256Arg Single submitter ⚠
p.Lys357Arg Single submitter ⚠
p.Lys362Arg Single submitter ⚠
p.Lys384Arg Single submitter ⚠
p.Lys38Asn Single submitter ⚠
p.Lys396Glu Single submitter ⚠
p.Lys485Gln Single submitter ⚠
p.Pro13Arg Single submitter ⚠
p.Pro326Ser Single submitter ⚠
p.Pro339Ser Single submitter ⚠
p.Pro416Thr Single submitter ⚠
p.Pro426Leu Single submitter ⚠
p.Pro427Ser Single submitter ⚠
p.Pro508Leu Single submitter ⚠
p.Pro515Ala Single submitter ⚠
p.Pro537Ser Single submitter ⚠
p.Pro637His Single submitter ⚠
p.Pro637Ser Single submitter ⚠
p.Pro73Thr Single submitter ⚠
p.Ser14Leu Single submitter ⚠
p.Ser218Asn Single submitter ⚠
p.Ser459Phe Single submitter ⚠
p.Ser542Cys Single submitter ⚠
p.Thr464Ala Single submitter ⚠
p.Thr734Ala Single submitter ⚠
p.Thr743Ser Single submitter ⚠
p.Tyr278Cys Single submitter ⚠
p.Tyr400Ser Single submitter ⚠
p.Val258Ile Single submitter ⚠
p.Val510Ala Single submitter ⚠
p.Val632Ile Single submitter ⚠
p.Val735Leu Single submitter ⚠
p.Val735Met Single submitter ⚠