TRAF2 — 69 ClinVar variants
All ClinVar germline TRAF2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
3 Benign · 3 Likely benign · 63 Uncertain significance
Full TRAF2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRAF2 p.Ala177Val Uncertain significance Single submitter
- TRAF2 p.Ala245Ser Uncertain significance Single submitter
- TRAF2 p.Ala254Gly Uncertain significance Single submitter
- TRAF2 p.Ala362Thr Uncertain significance Single submitter
- TRAF2 p.Ala3Val Uncertain significance Single submitter
- TRAF2 p.Ala420Thr Uncertain significance Single submitter
- TRAF2 p.Ala494Val Uncertain significance Single submitter
- TRAF2 p.Arg144Cys Uncertain significance Single submitter
- TRAF2 p.Arg167Gln Uncertain significance Single submitter
- TRAF2 p.Arg241Pro Uncertain significance Single submitter
- TRAF2 p.Arg308Gln Uncertain significance Single submitter
- TRAF2 p.Arg372His Uncertain significance Single submitter
- TRAF2 p.Arg52Gln Uncertain significance Single submitter
- TRAF2 p.Asn39Lys Uncertain significance Single submitter
- TRAF2 p.Asp450Asn Uncertain significance Single submitter
- TRAF2 p.Cys124Phe Uncertain significance Single submitter
- TRAF2 p.Cys182Arg Uncertain significance Single submitter
- TRAF2 p.Cys192Tyr Uncertain significance Single submitter
- TRAF2 p.Glu155Gln Uncertain significance Single submitter
- TRAF2 p.Glu158Gly Uncertain significance Single submitter
- TRAF2 p.Glu228Lys Uncertain significance Single submitter
- TRAF2 p.Gly172Arg Uncertain significance Single submitter
- TRAF2 p.Gly18Ser Uncertain significance Single submitter
- TRAF2 p.Gly210Asp Uncertain significance Single submitter
- TRAF2 p.Gly222Ser Uncertain significance Single submitter
- TRAF2 p.Gly265Arg Uncertain significance Single submitter
- TRAF2 p.His154Arg Uncertain significance Single submitter
- TRAF2 p.His154Asp Uncertain significance Single submitter
- TRAF2 p.His165Tyr Uncertain significance Single submitter
- TRAF2 p.Ile285Val Uncertain significance Single submitter
- TRAF2 p.Ile77Met Uncertain significance Single submitter
- TRAF2 p.Ile82Leu Uncertain significance Single submitter
- TRAF2 p.Leu131Arg Uncertain significance Single submitter
- TRAF2 p.Leu133Val Uncertain significance Single submitter
- TRAF2 p.Phe56Ser Uncertain significance Single submitter
- TRAF2 p.Pro17Ser Uncertain significance Single submitter
- TRAF2 p.Pro183Ser Uncertain significance Single submitter
- TRAF2 p.Pro9His Uncertain significance Single submitter
- TRAF2 p.Ser250Leu Uncertain significance Single submitter
- TRAF2 p.Ser483Ala Uncertain significance Single submitter
- TRAF2 p.Ser88Asn Uncertain significance Single submitter
- TRAF2 p.Thr279Met Uncertain significance Single submitter
- TRAF2 p.Tyr395His Uncertain significance Single submitter
- TRAF2 p.Tyr78Cys Uncertain significance Single submitter
- TRAF2 p.Val237Leu Uncertain significance Single submitter
- TRAF2 p.Val369Ala Uncertain significance Single submitter
- TRAF2 p.Val40Ile Uncertain significance Single submitter
- TRAF2 p.Val443Met Uncertain significance Single submitter
- TRAF2 p.Val451Met Uncertain significance Single submitter
- TRAF2 p.Val485Leu Uncertain significance Single submitter
- TRAF2 p.Val485Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- TRAF2 p.Ala446Thr Uncertain significance Single submitter
- TRAF2 p.Arg150Cys Uncertain significance Single submitter
- TRAF2 p.Asn94Lys Uncertain significance Single submitter
- TRAF2 p.Asp487Gly Uncertain significance Single submitter
- TRAF2 p.Glu276Gly Uncertain significance Single submitter
- TRAF2 p.Ile197Phe Uncertain significance Single submitter
- TRAF2 p.Lys320Glu Uncertain significance Single submitter
- TRAF2 p.Phe218Leu Uncertain significance Single submitter
- TRAF2 p.Ser55Phe Uncertain significance Single submitter
- TRAF2 p.Val100Leu Uncertain significance Single submitter
All TRAF2 variants
Likely benign 3
- p.Ala264Val Single submitter
- p.Arg128His Single submitter
- p.Arg150His Single submitter
Uncertain significance 63
- p.Ala177Val Single submitter ⚠
- p.Ala245Ser Single submitter ⚠
- p.Ala254Gly Single submitter ⚠
- p.Ala362Thr Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Ala420Thr Single submitter ⚠
- p.Ala446Thr Single submitter ⚠
- p.Ala494Val Single submitter ⚠
- p.Arg144Cys Single submitter ⚠
- p.Arg150Cys Single submitter ⚠
- p.Arg167Gln Single submitter ⚠
- p.Arg241Pro Single submitter ⚠
- p.Arg308Gln Single submitter ⚠
- p.Arg372His Single submitter ⚠
- p.Arg52Gln Single submitter ⚠
- p.Asn39Lys Single submitter ⚠
- p.Asn94Lys Single submitter ⚠
- p.Asp450Asn Single submitter ⚠
- p.Asp487Gly Single submitter ⚠
- p.Cys124Phe Single submitter ⚠
- p.Cys182Arg Single submitter ⚠
- p.Cys192Tyr Single submitter ⚠
- p.Glu155Gln Single submitter ⚠
- p.Glu158Gly Single submitter ⚠
- p.Glu228Lys Single submitter ⚠
- p.Glu276Gly Single submitter ⚠
- p.Glu325Ter Single submitter
- p.Gly172Arg Single submitter ⚠
- p.Gly18Ser Single submitter ⚠
- p.Gly210Asp Single submitter ⚠
- p.Gly222Ser Single submitter ⚠
- p.Gly265Arg Single submitter ⚠
- p.His154Arg Single submitter ⚠
- p.His154Asp Single submitter ⚠
- p.His165Tyr Single submitter ⚠
- p.Ile197Phe Single submitter ⚠
- p.Ile285Val Single submitter ⚠
- p.Ile77Met Single submitter ⚠
- p.Ile82Leu Single submitter ⚠
- p.Leu131Arg Single submitter ⚠
- p.Leu133Val Single submitter ⚠
- p.Leu62Phe Single submitter
- p.Lys320Glu Single submitter ⚠
- p.Phe218Leu Single submitter ⚠
- p.Phe56Ser Single submitter ⚠
- p.Pro17Ser Single submitter ⚠
- p.Pro183Ser Single submitter ⚠
- p.Pro9His Single submitter ⚠
- p.Ser250Leu Single submitter ⚠
- p.Ser483Ala Single submitter ⚠
- p.Ser55Phe Single submitter ⚠
- p.Ser88Asn Single submitter ⚠
- p.Thr279Met Single submitter ⚠
- p.Tyr395His Single submitter ⚠
- p.Tyr78Cys Single submitter ⚠
- p.Val100Leu Single submitter ⚠
- p.Val237Leu Single submitter ⚠
- p.Val369Ala Single submitter ⚠
- p.Val40Ile Single submitter ⚠
- p.Val443Met Single submitter ⚠
- p.Val451Met Single submitter ⚠
- p.Val485Leu Single submitter ⚠
- p.Val485Met Single submitter ⚠