Sugi Variant

Sugi Variant/TRAF3IP1

TRAF3IP1 — 510 ClinVar variants

All ClinVar germline TRAF3IP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 236 flagged for review →

21 Pathogenic · 1 Pathogenic/Likely pathogenic · 8 Likely pathogenic · 8 Conflicting · 27 Benign · 1 Benign/Likely benign · 178 Likely benign · 266 Uncertain significance

Full TRAF3IP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 236

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 8

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 190

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 190

Predictors split 38

The independent predictors disagree with each other — read with care.

All TRAF3IP1 variants

Pathogenic 21

Pathogenic/Likely pathogenic 1

  • p.Gln184fs Multiple submitters Senior-Loken syndrome 9

Likely pathogenic 8

Conflicting classifications of pathogenicity 8

Benign 27

Benign/Likely benign 1

Likely benign 178

Uncertain significance 266