Sugi Variant

Sugi Variant/TRAF3IP2

TRAF3IP2 — 211 ClinVar variants

All ClinVar germline TRAF3IP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 90 flagged for review →

10 Pathogenic · 5 Likely pathogenic · 2 Conflicting · 8 Benign · 6 Benign/Likely benign · 85 Likely benign · 95 Uncertain significance

Full TRAF3IP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 90

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 79

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 10

The independent predictors disagree with each other — read with care.

All TRAF3IP2 variants

Pathogenic 10

Likely pathogenic 5

Conflicting classifications of pathogenicity 2

  • p.Arg3Ter Single submitter candidiasis, familial, 8
  • p.Pro28Leu Single submitter candidiasis, familial, 8 ⚠

Benign 8

Benign/Likely benign 6

  • c.1291-13dup Multiple submitters candidiasis, familial, 8
  • p.Asp10Asn Multiple submitters candidiasis, familial, 8
  • p.His64Pro Multiple submitters candidiasis, familial, 8
  • p.Pro217Thr Multiple submitters candidiasis, familial, 8
  • p.Ser319Arg Multiple submitters candidiasis, familial, 8
  • p.Thr455= Multiple submitters candidiasis, familial, 8

Likely benign 85

  • c.1291-9T>G Multiple submitters candidiasis, familial, 8
  • c.1551+14_1551+17del Multiple submitters candidiasis, familial, 8
  • p.Asn395Ser Multiple submitters candidiasis, familial, 8
  • p.Asp280= Multiple submitters candidiasis, familial, 8
  • p.Gln79His Multiple submitters candidiasis, familial, 8
  • p.Ile459= Multiple submitters candidiasis, familial, 8
  • p.Leu422= Multiple submitters candidiasis, familial, 8
  • p.Pro292= Multiple submitters candidiasis, familial, 8
  • p.Pro327= Multiple submitters candidiasis, familial, 8
  • p.Pro373= Multiple submitters candidiasis, familial, 8
  • c.1022+16C>A Single submitter candidiasis, familial, 8
  • c.1022+7A>G Single submitter candidiasis, familial, 8
  • c.1023-4C>G Single submitter candidiasis, familial, 8
  • c.1023-6T>G Single submitter candidiasis, familial, 8
  • c.1023-9C>T Single submitter candidiasis, familial, 8
  • c.1201+12G>C Single submitter candidiasis, familial, 8
  • c.1202-16A>G Single submitter candidiasis, familial, 8
  • c.1202-19T>C Single submitter candidiasis, familial, 8
  • c.1290+15C>T Single submitter candidiasis, familial, 8
  • c.1290+20A>G Single submitter candidiasis, familial, 8
  • c.1291-14C>G Single submitter candidiasis, familial, 8
  • c.1291-8T>G Single submitter candidiasis, familial, 8
  • c.1360-13C>G Single submitter candidiasis, familial, 8
  • c.1360-15C>G Single submitter candidiasis, familial, 8
  • c.1360-9C>G Single submitter candidiasis, familial, 8
  • c.1476+7G>A Single submitter candidiasis, familial, 8
  • c.1477-15T>C Single submitter candidiasis, familial, 8
  • c.1551+10_1551+13del Single submitter candidiasis, familial, 8
  • c.1551+14G>C Single submitter candidiasis, familial, 8
  • c.1551+17del Single submitter candidiasis, familial, 8
  • c.1552-5C>T Single submitter candidiasis, familial, 8
  • c.1552-6C>A Single submitter candidiasis, familial, 8
  • c.829+7G>A Single submitter candidiasis, familial, 8
  • c.830-14G>A Single submitter candidiasis, familial, 8
  • c.830-15T>G Single submitter candidiasis, familial, 8
  • c.830-16T>G Single submitter candidiasis, familial, 8
  • c.830-7C>T Single submitter candidiasis, familial, 8
  • p.Ala302= Single submitter candidiasis, familial, 8
  • p.Ala328= Single submitter candidiasis, familial, 8
  • p.Ala363= Single submitter candidiasis, familial, 8
  • p.Ala412= Single submitter candidiasis, familial, 8
  • p.Ala473= Single submitter candidiasis, familial, 8
  • p.Ala49= Single submitter candidiasis, familial, 8
  • p.Arg3= Single submitter candidiasis, familial, 8
  • p.Arg3Gln Single submitter candidiasis, familial, 8
  • p.Arg542= Single submitter candidiasis, familial, 8
  • p.Asn395= Single submitter candidiasis, familial, 8
  • p.Asn425= Single submitter candidiasis, familial, 8
  • p.Asp331= Single submitter candidiasis, familial, 8
  • p.Asp469= Single submitter candidiasis, familial, 8
  • p.Asp478= Single submitter candidiasis, familial, 8
  • p.Gln525= Single submitter candidiasis, familial, 8
  • p.Glu357= Single submitter candidiasis, familial, 8
  • p.Glu448= Single submitter candidiasis, familial, 8
  • p.Gly336= Single submitter candidiasis, familial, 8
  • p.Gly472= Single submitter candidiasis, familial, 8
  • p.His323= Single submitter candidiasis, familial, 8
  • p.Ile508= Single submitter candidiasis, familial, 8
  • p.Leu391= Single submitter candidiasis, familial, 8
  • p.Leu560= Single submitter candidiasis, familial, 8
  • p.Lys312= Single submitter candidiasis, familial, 8
  • p.Phe418= Single submitter candidiasis, familial, 8
  • p.Pro224= Single submitter candidiasis, familial, 8
  • p.Pro24= Single submitter candidiasis, familial, 8
  • p.Pro28Arg Single submitter candidiasis, familial, 8
  • p.Pro298= Single submitter candidiasis, familial, 8
  • p.Pro318= Single submitter candidiasis, familial, 8
  • p.Pro335= Single submitter candidiasis, familial, 8
  • p.Pro344= Single submitter candidiasis, familial, 8
  • p.Pro370= Single submitter candidiasis, familial, 8
  • p.Pro533= Single submitter candidiasis, familial, 8
  • p.Pro558= Single submitter candidiasis, familial, 8
  • p.Pro564= Single submitter candidiasis, familial, 8
  • p.Ser383= Single submitter candidiasis, familial, 8
  • p.Ser408= Single submitter candidiasis, familial, 8
  • p.Ser48= Single submitter candidiasis, familial, 8
  • p.Ser57= Single submitter candidiasis, familial, 8
  • p.Thr411= Single submitter candidiasis, familial, 8
  • p.Thr51= Single submitter candidiasis, familial, 8
  • p.Thr559= Single submitter candidiasis, familial, 8
  • p.Tyr407= Single submitter candidiasis, familial, 8
  • p.Tyr549= Single submitter candidiasis, familial, 8
  • p.Val510= Single submitter candidiasis, familial, 8
  • p.Val529= Single submitter candidiasis, familial, 8
  • p.Val562= Single submitter candidiasis, familial, 8

Uncertain significance 95