TRAFD1 — 69 ClinVar variants
All ClinVar germline TRAFD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
1 Benign · 7 Likely benign · 61 Uncertain significance
Full TRAFD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRAFD1 p.Ala56Thr Uncertain significance Multiple submitters
- TRAFD1 p.Ala147Thr Uncertain significance Single submitter
- TRAFD1 p.Ala258Thr Uncertain significance Single submitter
- TRAFD1 p.Ala317Thr Uncertain significance Single submitter
- TRAFD1 p.Ala505Val Uncertain significance Single submitter
- TRAFD1 p.Ala554Ser Uncertain significance Single submitter
- TRAFD1 p.Arg112Trp Uncertain significance Single submitter
- TRAFD1 p.Arg264Ser Uncertain significance Single submitter
- TRAFD1 p.Arg316His Uncertain significance Single submitter
- TRAFD1 p.Arg406Gly Uncertain significance Single submitter
- TRAFD1 p.Arg499Gln Uncertain significance Single submitter
- TRAFD1 p.Arg515Cys Uncertain significance Single submitter
- TRAFD1 p.Arg550Gln Uncertain significance Single submitter
- TRAFD1 p.Arg550Trp Uncertain significance Single submitter
- TRAFD1 p.Asn151Thr Uncertain significance Single submitter
- TRAFD1 p.Asn548Thr Uncertain significance Single submitter
- TRAFD1 p.Asp351His Uncertain significance Single submitter
- TRAFD1 p.Asp435Gly Uncertain significance Single submitter
- TRAFD1 p.Asp575His Uncertain significance Single submitter
- TRAFD1 p.Cys267Tyr Uncertain significance Single submitter
- TRAFD1 p.Cys66Phe Uncertain significance Single submitter
- TRAFD1 p.Gln410Pro Uncertain significance Single submitter
- TRAFD1 p.Gln518His Uncertain significance Single submitter
- TRAFD1 p.Glu133Asp Uncertain significance Single submitter
- TRAFD1 p.Glu133Gln Uncertain significance Single submitter
- TRAFD1 p.Glu145Asp Uncertain significance Single submitter
- TRAFD1 p.Glu413Lys Uncertain significance Single submitter
- TRAFD1 p.Glu544Lys Uncertain significance Single submitter
- TRAFD1 p.Glu80Asp Uncertain significance Single submitter
- TRAFD1 p.Gly275Ser Uncertain significance Single submitter
- TRAFD1 p.Gly509Arg Uncertain significance Single submitter
- TRAFD1 p.Gly538Arg Uncertain significance Single submitter
- TRAFD1 p.Gly546Ser Uncertain significance Single submitter
- TRAFD1 p.His195Tyr Uncertain significance Single submitter
- TRAFD1 p.Leu169Phe Uncertain significance Single submitter
- TRAFD1 p.Leu186Val Uncertain significance Single submitter
- TRAFD1 p.Lys48Ile Uncertain significance Single submitter
- TRAFD1 p.Lys564Glu Uncertain significance Single submitter
- TRAFD1 p.Met179Val Uncertain significance Single submitter
- TRAFD1 p.Phe529Leu Uncertain significance Single submitter
- TRAFD1 p.Pro132Ala Uncertain significance Single submitter
- TRAFD1 p.Pro182Leu Uncertain significance Single submitter
- TRAFD1 p.Pro230Leu Uncertain significance Single submitter
- TRAFD1 p.Pro334Thr Uncertain significance Single submitter
- TRAFD1 p.Pro445Leu Uncertain significance Single submitter
- TRAFD1 p.Pro445Thr Uncertain significance Single submitter
- TRAFD1 p.Pro454Arg Uncertain significance Single submitter
- TRAFD1 p.Pro454Ser Uncertain significance Single submitter
- TRAFD1 p.Pro474Ala Uncertain significance Single submitter
- TRAFD1 p.Pro527Leu Uncertain significance Single submitter
- TRAFD1 p.Ser452Gly Uncertain significance Single submitter
- TRAFD1 p.Thr10Asn Uncertain significance Single submitter
- TRAFD1 p.Thr199Ala Uncertain significance Single submitter
- TRAFD1 p.Thr446Ile Uncertain significance Single submitter
- TRAFD1 p.Thr459Ile Uncertain significance Single submitter
- TRAFD1 p.Thr469Ile Uncertain significance Single submitter
- TRAFD1 p.Thr53Ser Uncertain significance Single submitter
- TRAFD1 p.Thr63Ile Uncertain significance Single submitter
- TRAFD1 p.Tyr108Asp Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All TRAFD1 variants
Benign 1
- p.Glu232= Multiple submitters
Likely benign 7
- p.Arg497Gln Single submitter
- p.Asn118Ser Single submitter
- p.Asn196Ser Single submitter
- p.Asn548Ser Single submitter
- p.Glu138Asp Single submitter
- p.Met38Val Single submitter
- p.Val266Ile Single submitter
Uncertain significance 61
- p.Ala56Thr Multiple submitters ⚠
- p.Ala147Thr Single submitter ⚠
- p.Ala258Thr Single submitter ⚠
- p.Ala317Thr Single submitter ⚠
- p.Ala505Val Single submitter ⚠
- p.Ala554Ser Single submitter ⚠
- p.Arg112Trp Single submitter ⚠
- p.Arg264Ser Single submitter ⚠
- p.Arg316His Single submitter ⚠
- p.Arg406Gly Single submitter ⚠
- p.Arg499Gln Single submitter ⚠
- p.Arg515Cys Single submitter ⚠
- p.Arg550Gln Single submitter ⚠
- p.Arg550Trp Single submitter ⚠
- p.Asn151Thr Single submitter ⚠
- p.Asn548Thr Single submitter ⚠
- p.Asp351His Single submitter ⚠
- p.Asp435Gly Single submitter ⚠
- p.Asp575His Single submitter ⚠
- p.Cys267Tyr Single submitter ⚠
- p.Cys66Phe Single submitter ⚠
- p.Gln410Pro Single submitter ⚠
- p.Gln518His Single submitter ⚠
- p.Glu133Asp Single submitter ⚠
- p.Glu133Gln Single submitter ⚠
- p.Glu145Asp Single submitter ⚠
- p.Glu413Lys Single submitter ⚠
- p.Glu544Lys Single submitter ⚠
- p.Glu80Asp Single submitter ⚠
- p.Gly275Ser Single submitter ⚠
- p.Gly509Arg Single submitter ⚠
- p.Gly538Arg Single submitter ⚠
- p.Gly546Ser Single submitter ⚠
- p.His195Tyr Single submitter ⚠
- p.Leu169Phe Single submitter ⚠
- p.Leu186Val Single submitter ⚠
- p.Lys48Ile Single submitter ⚠
- p.Lys564Glu Single submitter ⚠
- p.Met179Val Single submitter ⚠
- p.Met51Ile Single submitter ⚠
- p.Phe529Leu Single submitter ⚠
- p.Pro132Ala Single submitter ⚠
- p.Pro182Leu Single submitter ⚠
- p.Pro230Leu Single submitter ⚠
- p.Pro301Arg Single submitter ⚠
- p.Pro334Thr Single submitter ⚠
- p.Pro445Leu Single submitter ⚠
- p.Pro445Thr Single submitter ⚠
- p.Pro454Arg Single submitter ⚠
- p.Pro454Ser Single submitter ⚠
- p.Pro474Ala Single submitter ⚠
- p.Pro527Leu Single submitter ⚠
- p.Ser452Gly Single submitter ⚠
- p.Thr10Asn Single submitter ⚠
- p.Thr199Ala Single submitter ⚠
- p.Thr446Ile Single submitter ⚠
- p.Thr459Ile Single submitter ⚠
- p.Thr469Ile Single submitter ⚠
- p.Thr53Ser Single submitter ⚠
- p.Thr63Ile Single submitter ⚠
- p.Tyr108Asp Single submitter ⚠