Sugi Variant

Sugi Variant/TRAIP

TRAIP — 211 ClinVar variants

All ClinVar germline TRAIP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →

10 Pathogenic · 3 Likely pathogenic · 1 Conflicting · 16 Benign · 4 Benign/Likely benign · 90 Likely benign · 87 Uncertain significance

Full TRAIP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 79

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 52

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 25

The independent predictors disagree with each other — read with care.

All TRAIP variants

Pathogenic 10

Likely pathogenic 3

Conflicting classifications of pathogenicity 1

Benign 16

Benign/Likely benign 4

Likely benign 90

Uncertain significance 87