TRDMT1 — 58 ClinVar variants
All ClinVar germline TRDMT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
2 Benign · 3 Likely benign · 53 Uncertain significance
Full TRDMT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRDMT1 p.Arg162Gln Uncertain significance Single submitter
- TRDMT1 p.Arg369Cys Uncertain significance Single submitter
- TRDMT1 p.Arg87Gln Uncertain significance Single submitter
- TRDMT1 p.Asn40Asp Uncertain significance Single submitter
- TRDMT1 p.Asn97Ser Uncertain significance Single submitter
- TRDMT1 p.Asp255Glu Uncertain significance Single submitter
- TRDMT1 p.Asp259Asn Uncertain significance Single submitter
- TRDMT1 p.Asp259Val Uncertain significance Single submitter
- TRDMT1 p.Asp93Gly Uncertain significance Single submitter
- TRDMT1 p.Gln51Pro Uncertain significance Single submitter
- TRDMT1 p.Glu185Gly Uncertain significance Single submitter
- TRDMT1 p.Glu190Asp Uncertain significance Single submitter
- TRDMT1 p.Glu190Gln Uncertain significance Single submitter
- TRDMT1 p.Glu63Gln Uncertain significance Single submitter
- TRDMT1 p.Gly359Val Uncertain significance Single submitter
- TRDMT1 p.Ile137Val Uncertain significance Single submitter
- TRDMT1 p.Ile214Thr Uncertain significance Single submitter
- TRDMT1 p.Ile348Thr Uncertain significance Single submitter
- TRDMT1 p.Ile364Thr Uncertain significance Single submitter
- TRDMT1 p.Ile57Thr Uncertain significance Single submitter
- TRDMT1 p.Leu118Val Uncertain significance Single submitter
- TRDMT1 p.Leu132Phe Uncertain significance Single submitter
- TRDMT1 p.Leu154Ile Uncertain significance Single submitter
- TRDMT1 p.Leu257Phe Uncertain significance Single submitter
- TRDMT1 p.Met72Leu Uncertain significance Single submitter
- TRDMT1 p.Phe360Leu Uncertain significance Single submitter
- TRDMT1 p.Pro179Arg Uncertain significance Single submitter
- TRDMT1 p.Pro194Thr Uncertain significance Single submitter
- TRDMT1 p.Pro26Ala Uncertain significance Single submitter
- TRDMT1 p.Pro361Ser Uncertain significance Single submitter
- TRDMT1 p.Pro77Leu Uncertain significance Single submitter
- TRDMT1 p.Ser191Phe Uncertain significance Single submitter
- TRDMT1 p.Thr152Ala Uncertain significance Single submitter
- TRDMT1 p.Thr152Asn Uncertain significance Single submitter
- TRDMT1 p.Thr261Ala Uncertain significance Single submitter
- TRDMT1 p.Thr344Ile Uncertain significance Single submitter
- TRDMT1 p.Tyr342His Uncertain significance Single submitter
- TRDMT1 p.Val182Leu Uncertain significance Single submitter
- TRDMT1 p.Val192Leu Uncertain significance Single submitter
- TRDMT1 p.Val379Leu Uncertain significance Single submitter
- TRDMT1 p.Val379Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- TRDMT1 p.Ala383Thr Uncertain significance Single submitter
- TRDMT1 p.Arg21Gly Uncertain significance Single submitter
- TRDMT1 p.Arg369His Uncertain significance Single submitter
- TRDMT1 p.Asp71Gly Uncertain significance Single submitter
- TRDMT1 p.Gln368Glu Uncertain significance Single submitter
- TRDMT1 p.Thr152Pro Uncertain significance Single submitter
- TRDMT1 p.Thr96Met Uncertain significance Single submitter
- TRDMT1 p.Tyr266His Uncertain significance Single submitter
- TRDMT1 p.Val30Met Uncertain significance Single submitter
- TRDMT1 p.Val35Ala Uncertain significance Single submitter
All TRDMT1 variants
Benign 2
- p.Asp226Glu Multiple submitters
- p.Leu183= Multiple submitters
Likely benign 3
- p.Ala311Thr Single submitter
- p.His18Gln Single submitter
- p.Val291Met Single submitter
Uncertain significance 53
- p.Ala383Thr Single submitter ⚠
- p.Arg162Gln Single submitter ⚠
- p.Arg21Gly Single submitter ⚠
- p.Arg369Cys Single submitter ⚠
- p.Arg369His Single submitter ⚠
- p.Arg87Gln Single submitter ⚠
- p.Asn40Asp Single submitter ⚠
- p.Asn97Ser Single submitter ⚠
- p.Asp255Glu Single submitter ⚠
- p.Asp259Asn Single submitter ⚠
- p.Asp259Val Single submitter ⚠
- p.Asp71Gly Single submitter ⚠
- p.Asp93Gly Single submitter ⚠
- p.Gln368Glu Single submitter ⚠
- p.Gln51Pro Single submitter ⚠
- p.Glu185Gly Single submitter ⚠
- p.Glu190Asp Single submitter ⚠
- p.Glu190Gln Single submitter ⚠
- p.Glu63Gln Single submitter ⚠
- p.Gly359Val Single submitter ⚠
- p.Ile137Val Single submitter ⚠
- p.Ile214Thr Single submitter ⚠
- p.Ile348Thr Single submitter ⚠
- p.Ile364Thr Single submitter ⚠
- p.Ile57Thr Single submitter ⚠
- p.Leu118Val Single submitter ⚠
- p.Leu132Phe Single submitter ⚠
- p.Leu154Ile Single submitter ⚠
- p.Leu257Phe Single submitter ⚠
- p.Leu338Phe Single submitter
- p.Met72Leu Single submitter ⚠
- p.Phe360Leu Single submitter ⚠
- p.Pro179Arg Single submitter ⚠
- p.Pro194Thr Single submitter ⚠
- p.Pro26Ala Single submitter ⚠
- p.Pro361Ser Single submitter ⚠
- p.Pro77Leu Single submitter ⚠
- p.Ser191Phe Single submitter ⚠
- p.Thr152Ala Single submitter ⚠
- p.Thr152Asn Single submitter ⚠
- p.Thr152Pro Single submitter ⚠
- p.Thr261Ala Single submitter ⚠
- p.Thr344Ile Single submitter ⚠
- p.Thr96Met Single submitter ⚠
- p.Tyr266His Single submitter ⚠
- p.Tyr276His Single submitter
- p.Tyr342His Single submitter ⚠
- p.Val182Leu Single submitter ⚠
- p.Val192Leu Single submitter ⚠
- p.Val30Met Single submitter ⚠
- p.Val35Ala Single submitter ⚠
- p.Val379Leu Single submitter ⚠
- p.Val379Met Single submitter ⚠