TRIB1 — 34 ClinVar variants
All ClinVar germline TRIB1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
2 Benign · 2 Likely benign · 30 Uncertain significance
Full TRIB1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRIB1 p.Arg107Gln Uncertain significance Single submitter
- TRIB1 p.Arg174Gln Uncertain significance Single submitter
- TRIB1 p.Arg184Trp Uncertain significance Single submitter
- TRIB1 p.Arg321Gln Uncertain significance Single submitter
- TRIB1 p.Gln362Glu Uncertain significance Single submitter
- TRIB1 p.Glu217Ala Uncertain significance Single submitter
- TRIB1 p.His112Arg Uncertain significance Single submitter
- TRIB1 p.His112Tyr Uncertain significance Single submitter
- TRIB1 p.His126Gln Uncertain significance Single submitter
- TRIB1 p.Leu274Phe Uncertain significance Single submitter
- TRIB1 p.Lys187Arg Uncertain significance Single submitter
- TRIB1 p.Pro330Leu Uncertain significance Single submitter
- TRIB1 p.Ser141Asn Uncertain significance Single submitter
- TRIB1 p.Ser349Leu Uncertain significance Single submitter
- TRIB1 p.Ser368Asn Uncertain significance Single submitter
- TRIB1 p.Thr113Asn Uncertain significance Single submitter
- TRIB1 p.Val149Glu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TRIB1 p.Ala265Val Uncertain significance Single submitter
- TRIB1 p.Arg174Trp Uncertain significance Single submitter
- TRIB1 p.Arg178Trp Uncertain significance Single submitter
- TRIB1 p.Glu325Lys Uncertain significance Single submitter
- TRIB1 p.Glu331Ala Uncertain significance Single submitter
- TRIB1 p.Glu331Lys Uncertain significance Single submitter
- TRIB1 p.Gly165Glu Uncertain significance Single submitter
All TRIB1 variants
Benign 2
- p.Glu360Asp Multiple submitters
- p.Phe301= Multiple submitters
Uncertain significance 30
- p.Ala265Val Single submitter ⚠
- p.Arg107Gln Single submitter ⚠
- p.Arg174Gln Single submitter ⚠
- p.Arg174Trp Single submitter ⚠
- p.Arg178Trp Single submitter ⚠
- p.Arg184Trp Single submitter ⚠
- p.Arg312Gly Single submitter
- p.Arg321Gln Single submitter ⚠
- p.Gln362Glu Single submitter ⚠
- p.Glu217Ala Single submitter ⚠
- p.Glu227Asp Single submitter
- p.Glu325Lys Single submitter ⚠
- p.Glu331Ala Single submitter ⚠
- p.Glu331Lys Single submitter ⚠
- p.Gly165Glu Single submitter ⚠
- p.His112Arg Single submitter ⚠
- p.His112Tyr Single submitter ⚠
- p.His126Gln Single submitter ⚠
- p.Ile332Met Single submitter
- p.Leu274Phe Single submitter ⚠
- p.Lys187Arg Single submitter ⚠
- p.Met167Val Single submitter
- p.Pro123Leu Single submitter
- p.Pro330Leu Single submitter ⚠
- p.Ser141Asn Single submitter ⚠
- p.Ser349Leu Single submitter ⚠
- p.Ser368Asn Single submitter ⚠
- p.Thr113Asn Single submitter ⚠
- p.Val149Glu Single submitter ⚠
- p.Val279Ala Single submitter