TRIB2 — 35 ClinVar variants
All ClinVar germline TRIB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Benign · 1 Likely benign · 33 Uncertain significance
Full TRIB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRIB2 p.Ala102Ser Uncertain significance Single submitter
- TRIB2 p.Ala109Asp Uncertain significance Single submitter
- TRIB2 p.Ala160Thr Uncertain significance Single submitter
- TRIB2 p.Arg13Lys Uncertain significance Single submitter
- TRIB2 p.Arg203Gln Uncertain significance Single submitter
- TRIB2 p.Arg203Trp Uncertain significance Single submitter
- TRIB2 p.Arg77His Uncertain significance Single submitter
- TRIB2 p.Asn114Ser Uncertain significance Single submitter
- TRIB2 p.Asn19Ser Uncertain significance Single submitter
- TRIB2 p.Asp211Asn Uncertain significance Single submitter
- TRIB2 p.Cys106Ser Uncertain significance Single submitter
- TRIB2 p.Cys60Ser Uncertain significance Single submitter
- TRIB2 p.Glu186Lys Uncertain significance Single submitter
- TRIB2 p.Glu26Asp Uncertain significance Single submitter
- TRIB2 p.Glu26Gln Uncertain significance Single submitter
- TRIB2 p.Ile30Val Uncertain significance Single submitter
- TRIB2 p.Pro69His Uncertain significance Single submitter
- TRIB2 p.Ser100Tyr Uncertain significance Single submitter
- TRIB2 p.Ser32Thr Uncertain significance Single submitter
- TRIB2 p.Ser95Arg Uncertain significance Single submitter
- TRIB2 p.Thr21Ala Uncertain significance Single submitter
- TRIB2 p.Thr21Ser Uncertain significance Single submitter
- TRIB2 p.Tyr200His Uncertain significance Single submitter
- TRIB2 p.Tyr319His Uncertain significance Single submitter
- TRIB2 p.Val141Ile Uncertain significance Single submitter
- TRIB2 p.Val314Ile Uncertain significance Single submitter
- TRIB2 p.Val79Leu Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All TRIB2 variants
Benign 1
- c.563+10A>T Multiple submitters
Likely benign 1
- p.Ser100= Single submitter
Uncertain significance 33
- p.Ala102Ser Single submitter ⚠
- p.Ala109Asp Single submitter ⚠
- p.Ala160Thr Single submitter ⚠
- p.Arg13Lys Single submitter ⚠
- p.Arg18Leu Single submitter
- p.Arg203Gln Single submitter ⚠
- p.Arg203Trp Single submitter ⚠
- p.Arg291Gln Single submitter
- p.Arg77His Single submitter ⚠
- p.Asn114Ser Single submitter ⚠
- p.Asn19Ser Single submitter ⚠
- p.Asp211Asn Single submitter ⚠
- p.Cys106Ser Single submitter ⚠
- p.Cys60Ser Single submitter ⚠
- p.Glu186Lys Single submitter ⚠
- p.Glu258Lys Single submitter ⚠
- p.Glu26Asp Single submitter ⚠
- p.Glu26Gln Single submitter ⚠
- p.Ile30Val Single submitter ⚠
- p.Pro69His Single submitter ⚠
- p.Ser100Tyr Single submitter ⚠
- p.Ser210Phe Single submitter
- p.Ser32Thr Single submitter ⚠
- p.Ser6Phe Single submitter
- p.Ser95Arg Single submitter ⚠
- p.Thr21Ala Single submitter ⚠
- p.Thr21Ser Single submitter ⚠
- p.Tyr200His Single submitter ⚠
- p.Tyr319His Single submitter ⚠
- p.Val141Ile Single submitter ⚠
- p.Val219Ile Single submitter ⚠
- p.Val314Ile Single submitter ⚠
- p.Val79Leu Single submitter ⚠