TRIM24 — 75 ClinVar variants
All ClinVar germline TRIM24 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
1 Likely pathogenic · 4 Benign · 1 Likely benign · 69 Uncertain significance
Full TRIM24 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRIM24 p.Ala550Thr Uncertain significance Single submitter
- TRIM24 p.Ala603Pro Uncertain significance Single submitter
- TRIM24 p.Ala603Ser Uncertain significance Single submitter
- TRIM24 p.Arg1046Cys Uncertain significance Single submitter
- TRIM24 p.Asn1003Lys Uncertain significance Single submitter
- TRIM24 p.Asn160Thr Uncertain significance Single submitter
- TRIM24 p.Asn401Ser Uncertain significance Single submitter
- TRIM24 p.Asn402Asp Uncertain significance Single submitter
- TRIM24 p.Asn726Ser Uncertain significance Single submitter
- TRIM24 p.Asn754Ser Uncertain significance Single submitter
- TRIM24 p.Asn766Ser Uncertain significance Single submitter
- TRIM24 p.Asn799His Uncertain significance Single submitter
- TRIM24 p.Asn980Ser Uncertain significance Single submitter
- TRIM24 p.Asp883Asn Uncertain significance Single submitter
- TRIM24 p.Gln536Leu Uncertain significance Single submitter
- TRIM24 p.Gln789Arg Uncertain significance Single submitter
- TRIM24 p.Gln794His Uncertain significance Single submitter
- TRIM24 p.Glu731Ala Uncertain significance Single submitter
- TRIM24 p.Glu803Gln Uncertain significance Single submitter
- TRIM24 p.Glu978Asp Uncertain significance Single submitter
- TRIM24 p.Gly574Val Uncertain significance Single submitter
- TRIM24 p.Gly863Glu Uncertain significance Single submitter
- TRIM24 p.His534Pro Uncertain significance Single submitter
- TRIM24 p.Ile1043Thr Uncertain significance Single submitter
- TRIM24 p.Ile1043Val Uncertain significance Single submitter
- TRIM24 p.Lys552Thr Uncertain significance Single submitter
- TRIM24 p.Lys810Asn Uncertain significance Single submitter
- TRIM24 p.Met360Val Uncertain significance Single submitter
- TRIM24 p.Met498Val Uncertain significance Single submitter
- TRIM24 p.Met608Val Uncertain significance Single submitter
- TRIM24 p.Phe1024Leu Uncertain significance Single submitter
- TRIM24 p.Phe459Tyr Uncertain significance Single submitter
- TRIM24 p.Pro512Leu Uncertain significance Single submitter
- TRIM24 p.Pro553Gln Uncertain significance Single submitter
- TRIM24 p.Pro730Leu Uncertain significance Single submitter
- TRIM24 p.Pro790Ala Uncertain significance Single submitter
- TRIM24 p.Ser397Phe Uncertain significance Single submitter
- TRIM24 p.Ser453Pro Uncertain significance Single submitter
- TRIM24 p.Ser583Gly Uncertain significance Single submitter
- TRIM24 p.Ser654Pro Uncertain significance Single submitter
- TRIM24 p.Ser708Cys Uncertain significance Single submitter
- TRIM24 p.Ser758Asn Uncertain significance Single submitter
- TRIM24 p.Ser771Thr Uncertain significance Single submitter
- TRIM24 p.Ser797Ala Uncertain significance Single submitter
- TRIM24 p.Ser886Asn Uncertain significance Single submitter
- TRIM24 p.Ser889Ala Uncertain significance Single submitter
- TRIM24 p.Thr403Ile Uncertain significance Single submitter
- TRIM24 p.Thr577Ser Uncertain significance Single submitter
- TRIM24 p.Thr584Ala Uncertain significance Single submitter
- TRIM24 p.Val1033Ile Uncertain significance Single submitter
- TRIM24 p.Val441Met Uncertain significance Single submitter
- TRIM24 p.Val898Phe Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- TRIM24 p.Asp872Glu Benign Multiple submitters
- TRIM24 p.Ala262Val Uncertain significance Single submitter
- TRIM24 p.Arg1036Gln Uncertain significance Single submitter
- TRIM24 p.Arg126Cys Uncertain significance Single submitter
- TRIM24 p.Arg387Trp Uncertain significance Single submitter
- TRIM24 p.Gln266Glu Uncertain significance Single submitter
- TRIM24 p.Glu250Lys Uncertain significance Single submitter
- TRIM24 p.Leu241Val Uncertain significance Single submitter
- TRIM24 p.Leu717Met Uncertain significance Single submitter
- TRIM24 p.Lys937Thr Uncertain significance Single submitter
- TRIM24 p.Phe263Leu Uncertain significance Single submitter
- TRIM24 p.Pro682Arg Uncertain significance Single submitter
- TRIM24 p.Thr373Ile Uncertain significance Single submitter
All TRIM24 variants
Likely pathogenic 1
- p.Arg684Cys Single submitter ovarian cancer
Benign 4
- p.Asp872Glu Multiple submitters ⚠
- p.Ala26Thr Single submitter ovarian cancer
- p.Ala967Thr Single submitter ovarian cancer
- p.Ser780Thr Single submitter ovarian cancer
Likely benign 1
- p.Ile418= No assertion criteria TRIM24-related disorder
Uncertain significance 69
- p.Ala262Val Single submitter ⚠
- p.Ala550Thr Single submitter ⚠
- p.Ala603Pro Single submitter ⚠
- p.Ala603Ser Single submitter ⚠
- p.Arg1036Gln Single submitter ⚠
- p.Arg1046Cys Single submitter ⚠
- p.Arg126Cys Single submitter ⚠
- p.Arg387Trp Single submitter ⚠
- p.Arg391His Single submitter
- p.Arg515His Single submitter
- p.Asn1003Lys Single submitter ⚠
- p.Asn160Thr Single submitter ⚠
- p.Asn401Ser Single submitter ⚠
- p.Asn402Asp Single submitter ⚠
- p.Asn554Tyr Single submitter
- p.Asn726Ser Single submitter ⚠
- p.Asn754Ser Single submitter ⚠
- p.Asn766Ser Single submitter ⚠
- p.Asn799His Single submitter ⚠
- p.Asn980Ser Single submitter ⚠
- p.Asp883Asn Single submitter ⚠
- p.Gln266Glu Single submitter ⚠
- p.Gln536Leu Single submitter ⚠
- p.Gln789Arg Single submitter ⚠
- p.Gln794His Single submitter ⚠
- p.Glu250Lys Single submitter ⚠
- p.Glu731Ala Single submitter ⚠
- p.Glu803Gln Single submitter ⚠
- p.Glu978Asp Single submitter ⚠
- p.Gly574Val Single submitter ⚠
- p.Gly863Glu Single submitter ⚠
- p.His338Tyr Single submitter
- p.His534Pro Single submitter ⚠
- p.Ile1043Thr Single submitter ⚠
- p.Ile1043Val Single submitter ⚠
- p.Leu241Val Single submitter ⚠
- p.Leu717Met Single submitter ⚠
- p.Lys552Thr Single submitter ⚠
- p.Lys810Asn Single submitter ⚠
- p.Lys937Thr Single submitter ⚠
- p.Met360Val Single submitter ⚠
- p.Met498Arg Single submitter
- p.Met498Val Single submitter ⚠
- p.Met608Val Single submitter ⚠
- p.Phe1024Leu Single submitter ⚠
- p.Phe263Leu Single submitter ⚠
- p.Phe459Tyr Single submitter ⚠
- p.Pro512Leu Single submitter ⚠
- p.Pro553Gln Single submitter ⚠
- p.Pro682Arg Single submitter ⚠
- p.Pro730Leu Single submitter ⚠
- p.Pro790Ala Single submitter ⚠
- p.Ser397Phe Single submitter ⚠
- p.Ser453Pro Single submitter ⚠
- p.Ser583Gly Single submitter ⚠
- p.Ser654Pro Single submitter ⚠
- p.Ser708Cys Single submitter ⚠
- p.Ser758Asn Single submitter ⚠
- p.Ser771Thr Single submitter ⚠
- p.Ser797Ala Single submitter ⚠
- p.Ser886Asn Single submitter ⚠
- p.Ser889Ala Single submitter ⚠
- p.Thr373Ile Single submitter ⚠
- p.Thr403Ile Single submitter ⚠
- p.Thr577Ser Single submitter ⚠
- p.Thr584Ala Single submitter ⚠
- p.Val1033Ile Single submitter ⚠
- p.Val441Met Single submitter ⚠
- p.Val898Phe Single submitter ⚠