TRIM25 — 87 ClinVar variants
All ClinVar germline TRIM25 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
3 Benign · 9 Likely benign · 75 Uncertain significance
Full TRIM25 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 62
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRIM25 p.Ala114Val Uncertain significance Single submitter
- TRIM25 p.Ala254Thr Uncertain significance Single submitter
- TRIM25 p.Ala424Ser Uncertain significance Single submitter
- TRIM25 p.Ala424Val Uncertain significance Single submitter
- TRIM25 p.Ala547Thr Uncertain significance Single submitter
- TRIM25 p.Ala594Val Uncertain significance Single submitter
- TRIM25 p.Ala94Pro Uncertain significance Single submitter
- TRIM25 p.Ala94Thr Uncertain significance Single submitter
- TRIM25 p.Ala96Asp Uncertain significance Single submitter
- TRIM25 p.Arg231Trp Uncertain significance Single submitter
- TRIM25 p.Arg236Ser Uncertain significance Single submitter
- TRIM25 p.Arg489Trp Uncertain significance Single submitter
- TRIM25 p.Arg494Gly Uncertain significance Single submitter
- TRIM25 p.Arg83Trp Uncertain significance Single submitter
- TRIM25 p.Asn225Asp Uncertain significance Single submitter
- TRIM25 p.Asn487Lys Uncertain significance Single submitter
- TRIM25 p.Asn522Ser Uncertain significance Single submitter
- TRIM25 p.Asn534Ile Uncertain significance Single submitter
- TRIM25 p.Asn582Ser Uncertain significance Single submitter
- TRIM25 p.Asp151His Uncertain significance Single submitter
- TRIM25 p.Asp80Tyr Uncertain significance Single submitter
- TRIM25 p.Cys16Tyr Uncertain significance Single submitter
- TRIM25 p.Cys5Arg Uncertain significance Single submitter
- TRIM25 p.Gln132Lys Uncertain significance Single submitter
- TRIM25 p.Gln417Lys Uncertain significance Single submitter
- TRIM25 p.Glu421Asp Uncertain significance Single submitter
- TRIM25 p.Gly419Ala Uncertain significance Single submitter
- TRIM25 p.His160Pro Uncertain significance Single submitter
- TRIM25 p.His64Tyr Uncertain significance Single submitter
- TRIM25 p.Ile277Thr Uncertain significance Single submitter
- TRIM25 p.Ile528Thr Uncertain significance Single submitter
- TRIM25 p.Leu198Arg Uncertain significance Single submitter
- TRIM25 p.Leu251Val Uncertain significance Single submitter
- TRIM25 p.Leu37Val Uncertain significance Single submitter
- TRIM25 p.Leu599Met Uncertain significance Single submitter
- TRIM25 p.Lys21Thr Uncertain significance Single submitter
- TRIM25 p.Lys313Gln Uncertain significance Single submitter
- TRIM25 p.Lys332Arg Uncertain significance Single submitter
- TRIM25 p.Lys520Arg Uncertain significance Single submitter
- TRIM25 p.Met232Arg Uncertain significance Single submitter
- TRIM25 p.Pro101Arg Uncertain significance Single submitter
- TRIM25 p.Pro144Arg Uncertain significance Single submitter
- TRIM25 p.Pro147Leu Uncertain significance Single submitter
- TRIM25 p.Pro188Ser Uncertain significance Single submitter
- TRIM25 p.Pro370Thr Uncertain significance Single submitter
- TRIM25 p.Pro404Leu Uncertain significance Single submitter
- TRIM25 p.Ser259Leu Uncertain significance Single submitter
- TRIM25 p.Ser298Asn Uncertain significance Single submitter
- TRIM25 p.Ser372Pro Uncertain significance Single submitter
- TRIM25 p.Ser376Phe Uncertain significance Single submitter
- TRIM25 p.Ser428Arg Uncertain significance Single submitter
- TRIM25 p.Ser532Arg Uncertain significance Single submitter
- TRIM25 p.Thr207Ser Uncertain significance Single submitter
- TRIM25 p.Thr290Asn Uncertain significance Single submitter
- TRIM25 p.Thr341Ile Uncertain significance Single submitter
- TRIM25 p.Thr373Ala Uncertain significance Single submitter
- TRIM25 p.Thr556Ser Uncertain significance Single submitter
- TRIM25 p.Val105Glu Uncertain significance Single submitter
- TRIM25 p.Val230Met Uncertain significance Single submitter
- TRIM25 p.Val24Ala Uncertain significance Single submitter
- TRIM25 p.Val24Ile Uncertain significance Single submitter
- TRIM25 p.Val551Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- TRIM25 p.Gly586Arg Uncertain significance Single submitter
- TRIM25 p.His177Asp Uncertain significance Single submitter
- TRIM25 p.Lys602Glu Uncertain significance Single submitter
- TRIM25 p.Lys65Gln Uncertain significance Single submitter
- TRIM25 p.Met209Lys Uncertain significance Single submitter
- TRIM25 p.Ser14Phe Uncertain significance Single submitter
- TRIM25 p.Tyr48Asn Uncertain significance Single submitter
- TRIM25 p.Val270Phe Uncertain significance Single submitter
- TRIM25 p.Val470Met Uncertain significance Single submitter
All TRIM25 variants
Benign 3
- p.Ala216= Multiple submitters
- p.Thr185Ala Multiple submitters
- p.Thr575= Multiple submitters
Likely benign 9
- p.Ala189Val Single submitter
- p.Ala87Pro Single submitter
- p.Asp197Asn Single submitter
- p.Cys475Ser Single submitter
- p.Cys550= Single submitter
- p.His338Tyr Single submitter
- p.Ile457Val Single submitter
- p.Ser211Gly Single submitter
- p.Val238Met Single submitter
Uncertain significance 75
- p.Ala114Val Single submitter ⚠
- p.Ala124Val Single submitter
- p.Ala254Thr Single submitter ⚠
- p.Ala424Ser Single submitter ⚠
- p.Ala424Val Single submitter ⚠
- p.Ala547Thr Single submitter ⚠
- p.Ala594Val Single submitter ⚠
- p.Ala94Pro Single submitter ⚠
- p.Ala94Thr Single submitter ⚠
- p.Ala96Asp Single submitter ⚠
- p.Arg231Trp Single submitter ⚠
- p.Arg236Ser Single submitter ⚠
- p.Arg489Trp Single submitter ⚠
- p.Arg494Gly Single submitter ⚠
- p.Arg83Trp Single submitter ⚠
- p.Asn225Asp Single submitter ⚠
- p.Asn487Lys Single submitter ⚠
- p.Asn522Ser Single submitter ⚠
- p.Asn534Ile Single submitter ⚠
- p.Asn545Ser Single submitter
- p.Asn582Ser Single submitter ⚠
- p.Asp151His Single submitter ⚠
- p.Asp80Tyr Single submitter ⚠
- p.Cys16Tyr Single submitter ⚠
- p.Cys5Arg Single submitter ⚠
- p.Gln132Lys Single submitter ⚠
- p.Gln417Lys Single submitter ⚠
- p.Glu421Asp Single submitter ⚠
- p.Gly419Ala Single submitter ⚠
- p.Gly531Arg Single submitter
- p.Gly586Arg Single submitter ⚠
- p.His160Pro Single submitter ⚠
- p.His177Asp Single submitter ⚠
- p.His64Tyr Single submitter ⚠
- p.Ile277Thr Single submitter ⚠
- p.Ile528Thr Single submitter ⚠
- p.Leu198Arg Single submitter ⚠
- p.Leu251Val Single submitter ⚠
- p.Leu37Val Single submitter ⚠
- p.Leu599Met Single submitter ⚠
- p.Lys21Thr Single submitter ⚠
- p.Lys313Gln Single submitter ⚠
- p.Lys332Arg Single submitter ⚠
- p.Lys520Arg Single submitter ⚠
- p.Lys602Glu Single submitter ⚠
- p.Lys65Gln Single submitter ⚠
- p.Met209Lys Single submitter ⚠
- p.Met232Arg Single submitter ⚠
- p.Pro101Arg Single submitter ⚠
- p.Pro144Arg Single submitter ⚠
- p.Pro147Leu Single submitter ⚠
- p.Pro188Ser Single submitter ⚠
- p.Pro325Leu Single submitter
- p.Pro370Thr Single submitter ⚠
- p.Pro404Leu Single submitter ⚠
- p.Ser14Phe Single submitter ⚠
- p.Ser259Leu Single submitter ⚠
- p.Ser298Asn Single submitter ⚠
- p.Ser372Pro Single submitter ⚠
- p.Ser376Phe Single submitter ⚠
- p.Ser428Arg Single submitter ⚠
- p.Ser532Arg Single submitter ⚠
- p.Thr207Ser Single submitter ⚠
- p.Thr290Asn Single submitter ⚠
- p.Thr341Ile Single submitter ⚠
- p.Thr373Ala Single submitter ⚠
- p.Thr556Ser Single submitter ⚠
- p.Tyr48Asn Single submitter ⚠
- p.Val105Glu Single submitter ⚠
- p.Val230Met Single submitter ⚠
- p.Val24Ala Single submitter ⚠
- p.Val24Ile Single submitter ⚠
- p.Val270Phe Single submitter ⚠
- p.Val470Met Single submitter ⚠
- p.Val551Leu Single submitter ⚠