TRIM28 — 291 ClinVar variants
All ClinVar germline TRIM28 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →
9 Pathogenic · 5 Likely pathogenic · 1 Conflicting · 25 Benign · 6 Benign/Likely benign · 108 Likely benign · 137 Uncertain significance
Full TRIM28 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 113
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 88
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
TRIM28 p.Ala537Val
Uncertain significance
Multiple submitters
Wilms tumor 1
- TRIM28 p.Arg412His Uncertain significance Multiple submitters
-
TRIM28 p.Arg767His
Uncertain significance
Multiple submitters
Wilms tumor 1
-
TRIM28 p.Arg795Cys
Uncertain significance
Multiple submitters
Wilms tumor 1
- TRIM28 p.Asp231Tyr Uncertain significance Multiple submitters
-
TRIM28 p.Glu798Asp
Uncertain significance
Multiple submitters
Wilms tumor 1
-
TRIM28 p.Gly735Ala
Uncertain significance
Multiple submitters
Predisposition to Wilms tumor
- TRIM28 p.Gly735Ser Uncertain significance Multiple submitters
- TRIM28 p.His373Gln Uncertain significance Multiple submitters
-
TRIM28 p.Lys127Arg
Uncertain significance
Multiple submitters
Wilms tumor 1
- TRIM28 p.Pro698Leu Uncertain significance Multiple submitters
- TRIM28 p.Pro814Leu Uncertain significance Multiple submitters
-
TRIM28 p.Ser512Asn
Uncertain significance
Multiple submitters
Predisposition to Wilms tumor
- TRIM28 p.Thr558Met Uncertain significance Multiple submitters
- TRIM28 p.Tyr208Cys Uncertain significance Multiple submitters
- TRIM28 p.Val693Ala Uncertain significance Multiple submitters
- TRIM28 p.Ala143Ser Uncertain significance Single submitter
- TRIM28 p.Ala349Pro Uncertain significance Single submitter
- TRIM28 p.Ala528Gly Uncertain significance Single submitter
- TRIM28 p.Ala539Gly Uncertain significance Single submitter
- TRIM28 p.Ala561Val Uncertain significance Single submitter
- TRIM28 p.Ala580Asp Uncertain significance Single submitter
- TRIM28 p.Ala580Thr Uncertain significance Single submitter
- TRIM28 p.Ala582Pro Uncertain significance Single submitter
- TRIM28 p.Ala582Val Uncertain significance Single submitter
-
TRIM28 p.Ala687Gly
Uncertain significance
Single submitter
Wilms tumor 1
- TRIM28 p.Ala699Asp Uncertain significance Single submitter
- TRIM28 p.Ala710Ser Uncertain significance Single submitter
- TRIM28 p.Ala799Val Uncertain significance Single submitter
- TRIM28 p.Ala99Ser Uncertain significance Single submitter
- TRIM28 p.Arg230Gly Uncertain significance Single submitter
- TRIM28 p.Arg591Cys Uncertain significance Single submitter
- TRIM28 p.Arg629His Uncertain significance Single submitter
-
TRIM28 p.Arg702Trp
Uncertain significance
Single submitter
Predisposition to Wilms tumor
- TRIM28 p.Asn210Asp Uncertain significance Single submitter
- TRIM28 p.Asn210Ser Uncertain significance Single submitter
- TRIM28 p.Asn396Ser Uncertain significance Single submitter
- TRIM28 p.Asp116Glu Uncertain significance Single submitter
- TRIM28 p.Asp145Glu Uncertain significance Single submitter
- TRIM28 p.Asp455Asn Uncertain significance Single submitter
-
TRIM28 p.Asp685His
Uncertain significance
Single submitter
Predisposition to Wilms tumor
- TRIM28 p.Asp726Asn Uncertain significance Single submitter
- TRIM28 p.Asp732Tyr Uncertain significance Single submitter
- TRIM28 p.Gly450Ser Uncertain significance Single submitter
-
TRIM28 p.Gly454Glu
Uncertain significance
Single submitter
TRIM28-related disorder
- TRIM28 p.Gly476Ser Uncertain significance Single submitter
- TRIM28 p.Gly480Ser Uncertain significance Single submitter
- TRIM28 p.Gly532Ser Uncertain significance Single submitter
- TRIM28 p.Gly787Ser Uncertain significance Single submitter
- TRIM28 p.His214Leu Uncertain significance Single submitter
- TRIM28 p.His464Pro Uncertain significance Single submitter
- TRIM28 p.His464Tyr Uncertain significance Single submitter
- TRIM28 p.Ile345Val Uncertain significance Single submitter
- TRIM28 p.Leu547Met Uncertain significance Single submitter
- TRIM28 p.Leu547Val Uncertain significance Single submitter
- TRIM28 p.Leu578Phe Uncertain significance Single submitter
- TRIM28 p.Lys275Arg Uncertain significance Single submitter
- TRIM28 p.Lys400Arg Uncertain significance Single submitter
- TRIM28 p.Lys676Glu Uncertain significance Single submitter
- TRIM28 p.Met443Val Uncertain significance Single submitter
- TRIM28 p.Phe645Cys Uncertain significance Single submitter
- TRIM28 p.Pro161Ala Uncertain significance Single submitter
- TRIM28 p.Pro422Thr Uncertain significance Single submitter
- TRIM28 p.Pro431Leu Uncertain significance Single submitter
- TRIM28 p.Pro442Leu Uncertain significance Single submitter
- TRIM28 p.Pro457His Uncertain significance Single submitter
- TRIM28 p.Pro457Ser Uncertain significance Single submitter
- TRIM28 p.Pro590Leu Uncertain significance Single submitter
- TRIM28 p.Pro814Ser Uncertain significance Single submitter
- TRIM28 p.Ser140Gly Uncertain significance Single submitter
- TRIM28 p.Ser417Ala Uncertain significance Single submitter
- TRIM28 p.Ser473Pro Uncertain significance Single submitter
-
TRIM28 p.Ser727Pro
Uncertain significance
Single submitter
Predisposition to Wilms tumor
- TRIM28 p.Ser730Cys Uncertain significance Single submitter
- TRIM28 p.Thr144Ile Uncertain significance Single submitter
- TRIM28 p.Thr163Ser Uncertain significance Single submitter
- TRIM28 p.Thr274Ala Uncertain significance Single submitter
- TRIM28 p.Thr336Ser Uncertain significance Single submitter
- TRIM28 p.Thr359Arg Uncertain significance Single submitter
- TRIM28 p.Thr558Ser Uncertain significance Single submitter
- TRIM28 p.Thr574Pro Uncertain significance Single submitter
- TRIM28 p.Thr611Ile Uncertain significance Single submitter
- TRIM28 p.Val115Leu Uncertain significance Single submitter
- TRIM28 p.Val207Ile Uncertain significance Single submitter
- TRIM28 p.Val445Met Uncertain significance Single submitter
- TRIM28 p.Val605Leu Uncertain significance Single submitter
- TRIM28 p.Val606Met Uncertain significance Single submitter
- TRIM28 p.Val692Met Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- TRIM28 p.Arg706Cys Uncertain significance Multiple submitters
- TRIM28 p.Asn358Thr Benign/Likely benign Multiple submitters
-
TRIM28 p.Ser433Arg
Uncertain significance
Multiple submitters
Predisposition to Wilms tumor
- TRIM28 p.Arg524His Uncertain significance Single submitter
- TRIM28 p.Arg629Leu Uncertain significance Single submitter
- TRIM28 p.Arg706Leu Uncertain significance Single submitter
- TRIM28 p.Arg790Cys Uncertain significance Single submitter
- TRIM28 p.Asp247Asn Uncertain significance Single submitter
- TRIM28 p.Asp802Asn Uncertain significance Single submitter
- TRIM28 p.Gln789His Uncertain significance Single submitter
- TRIM28 p.Glu354Gly Uncertain significance Single submitter
- TRIM28 p.Glu354Val Uncertain significance Single submitter
- TRIM28 p.His267Asp Uncertain significance Single submitter
- TRIM28 p.His721Arg Uncertain significance Single submitter
-
TRIM28 p.Ile552Ser
Uncertain significance
Single submitter
Predisposition to Wilms tumor
- TRIM28 p.Lys199Asn Uncertain significance Single submitter
-
TRIM28 p.Met135Thr
Uncertain significance
Single submitter
Wilms tumor 1
- TRIM28 p.Met482Thr Uncertain significance Single submitter
- TRIM28 p.Pro753Ser Uncertain significance Single submitter
- TRIM28 p.Ser479Arg Uncertain significance Single submitter
- TRIM28 p.Ser598Arg Uncertain significance Single submitter
- TRIM28 p.Thr269Pro Uncertain significance Single submitter
- TRIM28 p.Val249Ala Uncertain significance Single submitter
- TRIM28 p.Val782Met Uncertain significance Single submitter
All TRIM28 variants
Pathogenic 9
- p.Ala160fs Single submitter Predisposition to Wilms tumor
- p.Gln331Ter Single submitter Predisposition to Wilms tumor
- p.Gln701Ter Single submitter Wilms tumor
- p.Glu343fs Single submitter
- p.Glu644fs Single submitter
- p.Pro614fs Single submitter
- p.Gln339Ter No assertion criteria Wilms tumor 7
- p.Glu175fs No assertion criteria Wilms tumor 7
- p.Glu583fs No assertion criteria Wilms tumor 7
Likely pathogenic 5
- c.1216+1G>A Single submitter Wilms tumor 7
- c.1216+1G>T Single submitter Predisposition to Wilms tumor
- c.839+1G>A Single submitter
- c.955-1G>A Single submitter Wilms tumor 7
- p.His714fs Single submitter Wilms tumor 7
Conflicting classifications of pathogenicity 1
- p.His386Gln Single submitter ⚠
Benign 25
- p.Lys390= Multiple submitters
- c.1102-5A>C Single submitter
- c.1216+19C>T Single submitter
- c.1217-15C>G Single submitter
- c.1323+5G>A Single submitter
- c.1360+13G>T Single submitter
- c.1361-20T>G Single submitter
- c.1662+20C>A Single submitter
- c.1663-11C>T Single submitter
- c.1663-20C>T Single submitter
- c.1983-15T>C Single submitter
- c.1983-19C>T Single submitter
- c.1983-5C>G Single submitter
- c.2107-11A>G Single submitter
- c.2193+20A>G Single submitter
- c.341-7C>T Single submitter
- c.453+12C>T Single submitter
- c.723-18A>C Single submitter
- c.840-6C>T Single submitter
- p.Ala349= Single submitter
- p.Arg427= Single submitter
- p.Asp286= Single submitter
- p.Pro716= Single submitter
- p.Pro754= Single submitter
- p.Thr728= Single submitter
Benign/Likely benign 6
- p.Ala527= Multiple submitters
- p.Ala537= Multiple submitters
- p.Asn358Thr Multiple submitters ⚠
- p.His190= Multiple submitters
- p.Pro118= Multiple submitters
- p.Thr567Ala Multiple submitters
Likely benign 108
- p.Asp781= Multiple submitters
- p.Gly535= Multiple submitters
- p.His464= Multiple submitters
- p.Lys340= Multiple submitters
- p.Pro566= Multiple submitters
- p.Pro618= Multiple submitters
- p.Pro734= Multiple submitters
- p.Thr728Ile Multiple submitters
- c.1101+18C>G Single submitter
- c.1101+4T>A Single submitter
- c.1101+9T>G Single submitter
- c.1102-19C>T Single submitter
- c.1216+7C>A Single submitter
- c.1217-13C>T Single submitter
- c.1217-15_1217-12del Single submitter
- c.1324-15C>A Single submitter
- c.1324-20G>A Single submitter
- c.1360+9G>A Single submitter
- c.1409+17C>T Single submitter
- c.1662+12C>G Single submitter
- c.1662+13C>T Single submitter
- c.1662+4A>G Single submitter
- c.1663-10C>T Single submitter
- c.1663-16C>T Single submitter
- c.1983-20C>T Single submitter
- c.1983-5C>T Single submitter
- c.1983-6C>A Single submitter
- c.2106+8C>T Single submitter
- c.2107-12C>A Single submitter
- c.2107-18C>T Single submitter
- c.2194-17G>A Single submitter
- c.2331+7C>T Single submitter
- c.340+12G>A Single submitter
- c.341-10C>T Single submitter
- c.341-13C>T Single submitter
- c.453+7C>T Single submitter
- c.454-13C>T Single submitter
- c.722+15A>G Single submitter
- c.839+20C>T Single submitter
- c.840-7C>T Single submitter
- c.954+14C>T Single submitter
- c.954+15G>T Single submitter
- c.954+7C>T Single submitter
- c.955-11_955-9del Single submitter
- p.Ala11= Single submitter
- p.Ala248= Single submitter
- p.Ala257Thr Single submitter
- p.Ala375= Single submitter
- p.Ala397= Single submitter
- p.Ala402= Single submitter
- p.Ala424= Single submitter
- p.Ala551= Single submitter
- p.Ala694= Single submitter
- p.Ala762= Single submitter
- p.Arg205= Single submitter
- p.Arg290= Single submitter
- p.Arg311= Single submitter
- p.Arg706= Single submitter
- p.Arg718= Single submitter
- p.Asn210= Single submitter
- p.Asn307= Single submitter
- p.Asn315= Single submitter
- p.Asp202Val Single submitter Wilms tumor 7
- p.Asp316= Single submitter
- p.Asp650= Single submitter
- p.Asp685= Single submitter
- p.Gln241= Single submitter
- p.Gln292= Single submitter
- p.Gln342= Single submitter
- p.Glu343= Single submitter
- p.Glu411= Single submitter
- p.Gly406= Single submitter
- p.Gly452= Single submitter
- p.Gly834= Single submitter
- p.His332= Single submitter
- p.His341= Single submitter
- p.Leu227= Single submitter
- p.Leu363= Single submitter
- p.Leu481= Single submitter
- p.Leu497= Single submitter
- p.Leu547= Single submitter
- p.Leu682= Single submitter
- p.Leu684= Single submitter
- p.Leu696= Single submitter
- p.Leu709= Single submitter
- p.Leu711= Single submitter
- p.Leu827= Single submitter
- p.Lys676= Single submitter
- p.Phe244= Single submitter
- p.Phe791= Single submitter
- p.Pro382= Single submitter
- p.Pro420Ser Single submitter
- p.Pro425Leu Single submitter
- p.Pro429Thr Single submitter
- p.Pro431= Single submitter
- p.Pro503= Single submitter
- p.Pro614= Single submitter
- p.Pro654= Single submitter
- p.Ser17= Single submitter
- p.Ser223= Single submitter
- p.Ser439= Single submitter
- p.Ser756= Single submitter
- p.Thr191= Single submitter
- p.Thr541= Single submitter
- p.Thr690= Single submitter
- p.Thr725= Single submitter
- p.Val707= Single submitter
- p.Ile786= No assertion criteria TRIM28-related disorder
Uncertain significance 137
- p.Ala537Val Multiple submitters Wilms tumor 1 ⚠
- p.Arg412His Multiple submitters ⚠
- p.Arg706Cys Multiple submitters ⚠
- p.Arg767His Multiple submitters Wilms tumor 1 ⚠
- p.Arg795Cys Multiple submitters Wilms tumor 1 ⚠
- p.Asp231Tyr Multiple submitters ⚠
- p.Glu798Asp Multiple submitters Wilms tumor 1 ⚠
- p.Gly735Ala Multiple submitters Predisposition to Wilms tumor ⚠
- p.Gly735Ser Multiple submitters ⚠
- p.His373Gln Multiple submitters ⚠
- p.Lys127Arg Multiple submitters Wilms tumor 1 ⚠
- p.Pro698Leu Multiple submitters ⚠
- p.Pro814Leu Multiple submitters ⚠
- p.Ser433Arg Multiple submitters Predisposition to Wilms tumor ⚠
- p.Ser512Asn Multiple submitters Predisposition to Wilms tumor ⚠
- p.Thr558Met Multiple submitters ⚠
- p.Tyr208Cys Multiple submitters ⚠
- p.Val693Ala Multiple submitters ⚠
- c.1101+7A>T Single submitter
- c.1101+8_1101+9dup Single submitter Wilms tumor 1
- c.1323+24_1323+71del Single submitter
- c.1410-3C>T Single submitter
- c.1663-3C>G Single submitter
- c.1983-3T>G Single submitter
- c.723-3C>T Single submitter
- c.955-6C>T Single submitter
- p.20PG[1] Single submitter
- p.2AASAA[2] Single submitter
- p.Ala143Ser Single submitter ⚠
- p.Ala349Pro Single submitter ⚠
- p.Ala528Gly Single submitter ⚠
- p.Ala52Pro Single submitter
- p.Ala539Gly Single submitter ⚠
- p.Ala561Val Single submitter ⚠
- p.Ala580_Ala582del Single submitter
- p.Ala580Asp Single submitter ⚠
- p.Ala580Thr Single submitter ⚠
- p.Ala582Pro Single submitter ⚠
- p.Ala582Val Single submitter ⚠
- p.Ala687Gly Single submitter Wilms tumor 1 ⚠
- p.Ala699Asp Single submitter ⚠
- p.Ala710Ser Single submitter ⚠
- p.Ala799Val Single submitter ⚠
- p.Ala8= Single submitter
- p.Ala99Ser Single submitter ⚠
- p.Arg230Gly Single submitter ⚠
- p.Arg524His Single submitter ⚠
- p.Arg591Cys Single submitter ⚠
- p.Arg629Cys Single submitter
- p.Arg629His Single submitter ⚠
- p.Arg629Leu Single submitter ⚠
- p.Arg702Trp Single submitter Predisposition to Wilms tumor ⚠
- p.Arg706Leu Single submitter ⚠
- p.Arg790Cys Single submitter ⚠
- p.Arg795= Single submitter
- p.Asn150= Single submitter
- p.Asn210Asp Single submitter ⚠
- p.Asn210Ser Single submitter ⚠
- p.Asn396Ser Single submitter ⚠
- p.Asp116Glu Single submitter ⚠
- p.Asp145Glu Single submitter ⚠
- p.Asp247Asn Single submitter ⚠
- p.Asp455Asn Single submitter ⚠
- p.Asp685His Single submitter Predisposition to Wilms tumor ⚠
- p.Asp726Asn Single submitter ⚠
- p.Asp732Tyr Single submitter ⚠
- p.Asp802Asn Single submitter ⚠
- p.Gln789His Single submitter ⚠
- p.Glu354Gly Single submitter ⚠
- p.Glu354Val Single submitter ⚠
- p.Gly436= Single submitter
- p.Gly450Ser Single submitter ⚠
- p.Gly454Glu Single submitter TRIM28-related disorder ⚠
- p.Gly476Ser Single submitter ⚠
- p.Gly480Ser Single submitter ⚠
- p.Gly532Ser Single submitter ⚠
- p.Gly787Ser Single submitter ⚠
- p.His214Leu Single submitter ⚠
- p.His267Asp Single submitter ⚠
- p.His464Pro Single submitter ⚠
- p.His464Tyr Single submitter ⚠
- p.His721Arg Single submitter ⚠
- p.Ile345Val Single submitter ⚠
- p.Ile552Ser Single submitter Predisposition to Wilms tumor ⚠
- p.Leu547Met Single submitter ⚠
- p.Leu547Val Single submitter ⚠
- p.Leu578Phe Single submitter ⚠
- p.Leu649Val Single submitter
- p.Lys199Asn Single submitter ⚠
- p.Lys275Arg Single submitter ⚠
- p.Lys319= Single submitter
- p.Lys400Arg Single submitter ⚠
- p.Lys676Glu Single submitter ⚠
- p.Met135Thr Single submitter Wilms tumor 1 ⚠
- p.Met443Val Single submitter ⚠
- p.Met482Thr Single submitter ⚠
- p.Phe645Cys Single submitter ⚠
- p.Phe800= Single submitter
- p.Pro161Ala Single submitter ⚠
- p.Pro422Thr Single submitter ⚠
- p.Pro431Leu Single submitter ⚠
- p.Pro442Leu Single submitter ⚠
- p.Pro457His Single submitter ⚠
- p.Pro457Ser Single submitter ⚠
- p.Pro504= Single submitter
- p.Pro534His Single submitter
- p.Pro590Leu Single submitter ⚠
- p.Pro753Ser Single submitter ⚠
- p.Pro814Ser Single submitter ⚠
- p.Ser140Gly Single submitter ⚠
- p.Ser417Ala Single submitter ⚠
- p.Ser473Pro Single submitter ⚠
- p.Ser479Arg Single submitter ⚠
- p.Ser598Arg Single submitter ⚠
- p.Ser727Pro Single submitter Predisposition to Wilms tumor ⚠
- p.Ser730Cys Single submitter ⚠
- p.Thr144Ile Single submitter ⚠
- p.Thr163Ser Single submitter ⚠
- p.Thr228= Single submitter
- p.Thr269Pro Single submitter ⚠
- p.Thr274Ala Single submitter ⚠
- p.Thr336Ser Single submitter ⚠
- p.Thr359Arg Single submitter ⚠
- p.Thr558Ser Single submitter ⚠
- p.Thr574Pro Single submitter ⚠
- p.Thr611Ile Single submitter ⚠
- p.Tyr133= Single submitter
- p.Val115Leu Single submitter ⚠
- p.Val207Ile Single submitter ⚠
- p.Val249Ala Single submitter ⚠
- p.Val295= Single submitter
- p.Val445Met Single submitter ⚠
- p.Val605Leu Single submitter ⚠
- p.Val606Met Single submitter ⚠
- p.Val692Met Single submitter ⚠
- p.Val782Met Single submitter ⚠
- c.2193+3G>T No assertion criteria prostate cancer