TRIM58 — 69 ClinVar variants
All ClinVar germline TRIM58 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
2 Likely benign · 67 Uncertain significance
Full TRIM58 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRIM58 p.Ala206Val Uncertain significance Single submitter
- TRIM58 p.Ala308Thr Uncertain significance Single submitter
- TRIM58 p.Ala356Thr Uncertain significance Single submitter
- TRIM58 p.Ala453Val Uncertain significance Single submitter
- TRIM58 p.Ala4Thr Uncertain significance Single submitter
- TRIM58 p.Ala93Thr Uncertain significance Single submitter
- TRIM58 p.Arg105Gly Uncertain significance Single submitter
- TRIM58 p.Arg181Cys Uncertain significance Single submitter
- TRIM58 p.Arg190His Uncertain significance Single submitter
- TRIM58 p.Arg190Leu Uncertain significance Single submitter
- TRIM58 p.Arg199Trp Uncertain significance Single submitter
- TRIM58 p.Arg216Gln Uncertain significance Single submitter
- TRIM58 p.Arg320Lys Uncertain significance Single submitter
- TRIM58 p.Arg345Ser Uncertain significance Single submitter
- TRIM58 p.Arg409His Uncertain significance Single submitter
- TRIM58 p.Arg98Pro Uncertain significance Single submitter
- TRIM58 p.Arg9Trp Uncertain significance Single submitter
- TRIM58 p.Asn426Ser Uncertain significance Single submitter
- TRIM58 p.Asn72Ser Uncertain significance Single submitter
- TRIM58 p.Asp321His Uncertain significance Single submitter
- TRIM58 p.Asp473Asn Uncertain significance Single submitter
- TRIM58 p.Cys16Tyr Uncertain significance Single submitter
- TRIM58 p.Cys278Tyr Uncertain significance Single submitter
- TRIM58 p.Gln133Leu Uncertain significance Single submitter
- TRIM58 p.Gln160Arg Uncertain significance Single submitter
- TRIM58 p.Gln198Arg Uncertain significance Single submitter
- TRIM58 p.Gln314Arg Uncertain significance Single submitter
- TRIM58 p.Glu101Gln Uncertain significance Single submitter
- TRIM58 p.Glu148Val Uncertain significance Single submitter
- TRIM58 p.Glu176Lys Uncertain significance Single submitter
- TRIM58 p.Glu197Ala Uncertain significance Single submitter
- TRIM58 p.Glu349Asp Uncertain significance Single submitter
- TRIM58 p.Glu391Lys Uncertain significance Single submitter
- TRIM58 p.Gly467Ala Uncertain significance Single submitter
- TRIM58 p.Gly7Arg Uncertain significance Single submitter
- TRIM58 p.Ile413Val Uncertain significance Single submitter
- TRIM58 p.Leu114Pro Uncertain significance Single submitter
- TRIM58 p.Leu338Ser Uncertain significance Single submitter
- TRIM58 p.Leu387Met Uncertain significance Single submitter
- TRIM58 p.Leu403Phe Uncertain significance Single submitter
- TRIM58 p.Lys142Arg Uncertain significance Single submitter
- TRIM58 p.Lys288Thr Uncertain significance Single submitter
- TRIM58 p.Lys370Asn Uncertain significance Single submitter
- TRIM58 p.Met145Leu Uncertain significance Single submitter
- TRIM58 p.Phe35Ile Uncertain significance Single submitter
- TRIM58 p.Pro368Arg Uncertain significance Single submitter
- TRIM58 p.Pro368Ser Uncertain significance Single submitter
- TRIM58 p.Pro5Leu Uncertain significance Single submitter
- TRIM58 p.Thr454Asn Uncertain significance Single submitter
- TRIM58 p.Trp3Arg Uncertain significance Single submitter
- TRIM58 p.Trp469Arg Uncertain significance Single submitter
- TRIM58 p.Tyr417Cys Uncertain significance Single submitter
- TRIM58 p.Val164Met Uncertain significance Single submitter
- TRIM58 p.Val481Glu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- TRIM58 p.Arg221Trp Uncertain significance Single submitter
- TRIM58 p.Arg257Gly Uncertain significance Single submitter
- TRIM58 p.Arg61Gly Uncertain significance Single submitter
- TRIM58 p.Gln339Arg Uncertain significance Single submitter
- TRIM58 p.Gly442Val Uncertain significance Single submitter
- TRIM58 p.His99Gln Uncertain significance Single submitter
- TRIM58 p.Leu193Arg Uncertain significance Single submitter
- TRIM58 p.Leu215Arg Uncertain significance Single submitter
- TRIM58 p.Leu229Pro Uncertain significance Single submitter
- TRIM58 p.Pro302Arg Uncertain significance Single submitter
- TRIM58 p.Pro377Leu Uncertain significance Single submitter
All TRIM58 variants
Likely benign 2
- p.Asn163Ser Single submitter
- p.Lys274Arg Single submitter
Uncertain significance 67
- p.Ala206Val Single submitter ⚠
- p.Ala308Thr Single submitter ⚠
- p.Ala356Thr Single submitter ⚠
- p.Ala453Val Single submitter ⚠
- p.Ala4Thr Single submitter ⚠
- p.Ala93Thr Single submitter ⚠
- p.Arg105Gly Single submitter ⚠
- p.Arg181Cys Single submitter ⚠
- p.Arg190His Single submitter ⚠
- p.Arg190Leu Single submitter ⚠
- p.Arg199Trp Single submitter ⚠
- p.Arg216Gln Single submitter ⚠
- p.Arg221Trp Single submitter ⚠
- p.Arg257Gly Single submitter ⚠
- p.Arg320Lys Single submitter ⚠
- p.Arg345Ser Single submitter ⚠
- p.Arg409His Single submitter ⚠
- p.Arg445Trp Single submitter
- p.Arg61Gly Single submitter ⚠
- p.Arg98Pro Single submitter ⚠
- p.Arg9Trp Single submitter ⚠
- p.Asn426Ser Single submitter ⚠
- p.Asn72Ser Single submitter ⚠
- p.Asp321His Single submitter ⚠
- p.Asp473Asn Single submitter ⚠
- p.Cys16Tyr Single submitter ⚠
- p.Cys278Tyr Single submitter ⚠
- p.Gln133Leu Single submitter ⚠
- p.Gln160Arg Single submitter ⚠
- p.Gln198Arg Single submitter ⚠
- p.Gln314Arg Single submitter ⚠
- p.Gln339Arg Single submitter ⚠
- p.Glu101Gln Single submitter ⚠
- p.Glu148Val Single submitter ⚠
- p.Glu176Lys Single submitter ⚠
- p.Glu197Ala Single submitter ⚠
- p.Glu349Asp Single submitter ⚠
- p.Glu391Lys Single submitter ⚠
- p.Gly442Val Single submitter ⚠
- p.Gly467Ala Single submitter ⚠
- p.Gly7Arg Single submitter ⚠
- p.His99Gln Single submitter ⚠
- p.Ile413Val Single submitter ⚠
- p.Leu114Pro Single submitter ⚠
- p.Leu193Arg Single submitter ⚠
- p.Leu215Arg Single submitter ⚠
- p.Leu229Pro Single submitter ⚠
- p.Leu338Ser Single submitter ⚠
- p.Leu387Met Single submitter ⚠
- p.Leu403Phe Single submitter ⚠
- p.Lys142Arg Single submitter ⚠
- p.Lys288Thr Single submitter ⚠
- p.Lys370Asn Single submitter ⚠
- p.Met145Leu Single submitter ⚠
- p.Phe35Ile Single submitter ⚠
- p.Pro302Arg Single submitter ⚠
- p.Pro368Arg Single submitter ⚠
- p.Pro368Ser Single submitter ⚠
- p.Pro377Leu Single submitter ⚠
- p.Pro5Leu Single submitter ⚠
- p.Thr299Met Single submitter
- p.Thr454Asn Single submitter ⚠
- p.Trp3Arg Single submitter ⚠
- p.Trp469Arg Single submitter ⚠
- p.Tyr417Cys Single submitter ⚠
- p.Val164Met Single submitter ⚠
- p.Val481Glu Single submitter ⚠