TRIM59 — 53 ClinVar variants
All ClinVar germline TRIM59 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
3 Likely benign · 50 Uncertain significance
Full TRIM59 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRIM59 p.Arg21His Uncertain significance Single submitter
- TRIM59 p.Arg60Gly Uncertain significance Single submitter
- TRIM59 p.Asn215Tyr Uncertain significance Single submitter
- TRIM59 p.Asn377Ser Uncertain significance Single submitter
- TRIM59 p.Asn384Ser Uncertain significance Single submitter
- TRIM59 p.Asp209Gly Uncertain significance Single submitter
- TRIM59 p.Cys109Arg Uncertain significance Single submitter
- TRIM59 p.Cys109Gly Uncertain significance Single submitter
- TRIM59 p.Cys10Tyr Uncertain significance Single submitter
- TRIM59 p.Gln135His Uncertain significance Single submitter
- TRIM59 p.Gln135Pro Uncertain significance Single submitter
- TRIM59 p.Gln232His Uncertain significance Single submitter
- TRIM59 p.Gln88Glu Uncertain significance Single submitter
- TRIM59 p.Glu366Gly Uncertain significance Single submitter
- TRIM59 p.Glu89Lys Uncertain significance Single submitter
- TRIM59 p.His260Gln Uncertain significance Single submitter
- TRIM59 p.Ile277Val Uncertain significance Single submitter
- TRIM59 p.Ile332Leu Uncertain significance Single submitter
- TRIM59 p.Ile353Val Uncertain significance Single submitter
- TRIM59 p.Ile389Val Uncertain significance Single submitter
- TRIM59 p.Ile46Leu Uncertain significance Single submitter
- TRIM59 p.Ile94Thr Uncertain significance Single submitter
- TRIM59 p.Leu160Phe Uncertain significance Single submitter
- TRIM59 p.Leu375Ser Uncertain significance Single submitter
- TRIM59 p.Leu392Ser Uncertain significance Single submitter
- TRIM59 p.Lys201Arg Uncertain significance Single submitter
- TRIM59 p.Lys310Asn Uncertain significance Single submitter
- TRIM59 p.Lys328Arg Uncertain significance Single submitter
- TRIM59 p.Met236Arg Uncertain significance Single submitter
- TRIM59 p.Phe347Cys Uncertain significance Single submitter
- TRIM59 p.Pro11Ser Uncertain significance Single submitter
- TRIM59 p.Pro145Ser Uncertain significance Single submitter
- TRIM59 p.Pro309Leu Uncertain significance Single submitter
- TRIM59 p.Ser136Asn Uncertain significance Single submitter
- TRIM59 p.Ser172Ala Uncertain significance Single submitter
- TRIM59 p.Ser339Pro Uncertain significance Single submitter
- TRIM59 p.Thr161Asn Uncertain significance Single submitter
- TRIM59 p.Thr205Lys Uncertain significance Single submitter
- TRIM59 p.Thr205Met Uncertain significance Single submitter
- TRIM59 p.Thr336Ile Uncertain significance Single submitter
- TRIM59 p.Trp157Leu Uncertain significance Single submitter
- TRIM59 p.Tyr218Cys Uncertain significance Single submitter
- TRIM59 p.Tyr391Asn Uncertain significance Single submitter
- TRIM59 p.Val281Leu Uncertain significance Single submitter
- TRIM59 p.Val300Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All TRIM59 variants
Likely benign 3
- p.His403Arg Single submitter
- p.Ile362Val Single submitter
- p.Val397Met Single submitter
Uncertain significance 50
- p.Arg21His Single submitter ⚠
- p.Arg60Gly Single submitter ⚠
- p.Asn215Tyr Single submitter ⚠
- p.Asn377Ser Single submitter ⚠
- p.Asn384Ser Single submitter ⚠
- p.Asp181Tyr Single submitter ⚠
- p.Asp209Gly Single submitter ⚠
- p.Cys109Arg Single submitter ⚠
- p.Cys109Gly Single submitter ⚠
- p.Cys10Tyr Single submitter ⚠
- p.Gln135His Single submitter ⚠
- p.Gln135Pro Single submitter ⚠
- p.Gln232His Single submitter ⚠
- p.Gln88Glu Single submitter ⚠
- p.Glu366Gly Single submitter ⚠
- p.Glu89Lys Single submitter ⚠
- p.His260Gln Single submitter ⚠
- p.Ile277Val Single submitter ⚠
- p.Ile332Leu Single submitter ⚠
- p.Ile353Val Single submitter ⚠
- p.Ile389Val Single submitter ⚠
- p.Ile46Leu Single submitter ⚠
- p.Ile70Phe Single submitter ⚠
- p.Ile94Thr Single submitter ⚠
- p.Leu160Phe Single submitter ⚠
- p.Leu375Ser Single submitter ⚠
- p.Leu386Pro Single submitter ⚠
- p.Leu392Ser Single submitter ⚠
- p.Lys201Arg Single submitter ⚠
- p.Lys310Asn Single submitter ⚠
- p.Lys328Arg Single submitter ⚠
- p.Met236Arg Single submitter ⚠
- p.Phe189Leu Single submitter ⚠
- p.Phe347Cys Single submitter ⚠
- p.Pro11Ser Single submitter ⚠
- p.Pro145Ser Single submitter ⚠
- p.Pro220Ala Single submitter ⚠
- p.Pro309Leu Single submitter ⚠
- p.Ser136Asn Single submitter ⚠
- p.Ser172Ala Single submitter ⚠
- p.Ser339Pro Single submitter ⚠
- p.Thr161Asn Single submitter ⚠
- p.Thr205Lys Single submitter ⚠
- p.Thr205Met Single submitter ⚠
- p.Thr336Ile Single submitter ⚠
- p.Trp157Leu Single submitter ⚠
- p.Tyr218Cys Single submitter ⚠
- p.Tyr391Asn Single submitter ⚠
- p.Val281Leu Single submitter ⚠
- p.Val300Ile Single submitter ⚠