Sugi Variant

Sugi Variant/TRIM63

TRIM63 — 154 ClinVar variants

All ClinVar germline TRIM63 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →

3 Pathogenic · 3 Likely pathogenic · 8 Conflicting · 18 Benign · 4 Benign/Likely benign · 27 Likely benign · 91 Uncertain significance

Full TRIM63 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 87

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 5

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 63

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 19

The independent predictors disagree with each other — read with care.

All TRIM63 variants

Pathogenic 3

  • p.Ser161fs Multiple submitters Inborn genetic diseases
  • p.Gln93Ter Single submitter idiopathic cardiomyopathy
  • p.Leu319Pro No assertion criteria cardiomyopathy, familial hypertrophic, 31

Likely pathogenic 3

Conflicting classifications of pathogenicity 8

Benign 18

Benign/Likely benign 4

Likely benign 27

Uncertain significance 91