TRPA1 — 219 ClinVar variants
All ClinVar germline TRPA1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 121 flagged for review →
6 Conflicting · 23 Benign · 2 Benign/Likely benign · 60 Likely benign · 128 Uncertain significance
Full TRPA1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 121
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 4
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
TRPA1 p.Asp412Asn
Conflicting
Single submitter
familial episodic pain syndrome with predominantly upper body involvement
- TRPA1 p.Ile255Val Conflicting Single submitter
- TRPA1 p.Ile469Val Conflicting Single submitter
- TRPA1 p.Ser293Leu Conflicting Single submitter
Predictors lean, ClinVar uncertain 95
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
TRPA1 p.His309Tyr
Uncertain significance
Multiple submitters
familial episodic pain syndrome with predominantly upper body involvement
- TRPA1 p.His418Gln Uncertain significance Multiple submitters
- TRPA1 p.Lys504Arg Uncertain significance Multiple submitters
- TRPA1 p.Met1042Val Uncertain significance Multiple submitters
- TRPA1 p.Ala189Asp Uncertain significance Single submitter
- TRPA1 p.Ala521Val Uncertain significance Single submitter
- TRPA1 p.Ala581Thr Uncertain significance Single submitter
- TRPA1 p.Ala745Thr Uncertain significance Single submitter
-
TRPA1 p.Ala789Val
Uncertain significance
Single submitter
familial episodic pain syndrome with predominantly upper body involvement
- TRPA1 p.Arg1102Thr Uncertain significance Single submitter
- TRPA1 p.Arg343His Uncertain significance Single submitter
- TRPA1 p.Arg376Cys Uncertain significance Single submitter
- TRPA1 p.Arg543His Uncertain significance Single submitter
- TRPA1 p.Arg58Ser Uncertain significance Single submitter
- TRPA1 p.Arg652Leu Uncertain significance Single submitter
- TRPA1 p.Arg694His Uncertain significance Single submitter
- TRPA1 p.Arg6Gly Uncertain significance Single submitter
- TRPA1 p.Asn237Lys Uncertain significance Single submitter
- TRPA1 p.Asn411Lys Uncertain significance Single submitter
- TRPA1 p.Asn49Asp Uncertain significance Single submitter
- TRPA1 p.Asn571Lys Uncertain significance Single submitter
- TRPA1 p.Asn619Ser Uncertain significance Single submitter
-
TRPA1 p.Asn692His
Uncertain significance
Single submitter
familial episodic pain syndrome with predominantly upper body involvement
- TRPA1 p.Asp468Glu Uncertain significance Single submitter
- TRPA1 p.Asp61Asn Uncertain significance Single submitter
- TRPA1 p.Cys199Arg Uncertain significance Single submitter
-
TRPA1 p.Cys462Arg
Uncertain significance
Single submitter
familial episodic pain syndrome with predominantly upper body involvement
- TRPA1 p.Gln423Glu Uncertain significance Single submitter
- TRPA1 p.Glu107Lys Uncertain significance Single submitter
- TRPA1 p.Glu16Asp Uncertain significance Single submitter
- TRPA1 p.Glu41Asp Uncertain significance Single submitter
- TRPA1 p.Glu657Lys Uncertain significance Single submitter
- TRPA1 p.Glu93Gly Uncertain significance Single submitter
- TRPA1 p.Gly121Arg Uncertain significance Single submitter
- TRPA1 p.Gly209Val Uncertain significance Single submitter
- TRPA1 p.Gly365Asp Uncertain significance Single submitter
- TRPA1 p.Gly424Arg Uncertain significance Single submitter
- TRPA1 p.Gly425Ser Uncertain significance Single submitter
- TRPA1 p.Gly42Glu Uncertain significance Single submitter
- TRPA1 p.Gly524Ser Uncertain significance Single submitter
- TRPA1 p.Gly525Arg Uncertain significance Single submitter
- TRPA1 p.His589Gln Uncertain significance Single submitter
- TRPA1 p.Ile111Thr Uncertain significance Single submitter
- TRPA1 p.Ile171Phe Uncertain significance Single submitter
- TRPA1 p.Ile171Thr Uncertain significance Single submitter
- TRPA1 p.Ile459Phe Uncertain significance Single submitter
- TRPA1 p.Ile656Met Uncertain significance Single submitter
- TRPA1 p.Ile761Met Uncertain significance Single submitter
- TRPA1 p.Ile76Asn Uncertain significance Single submitter
- TRPA1 p.Ile770Met Uncertain significance Single submitter
- TRPA1 p.Leu1051Pro Uncertain significance Single submitter
- TRPA1 p.Leu480His Uncertain significance Single submitter
- TRPA1 p.Leu480Phe Uncertain significance Single submitter
- TRPA1 p.Leu637Ile Uncertain significance Single submitter
- TRPA1 p.Leu663His Uncertain significance Single submitter
- TRPA1 p.Leu730Phe Uncertain significance Single submitter
- TRPA1 p.Leu769Ile Uncertain significance Single submitter
- TRPA1 p.Lys196Arg Uncertain significance Single submitter
- TRPA1 p.Lys337Gln Uncertain significance Single submitter
- TRPA1 p.Lys54Asn Uncertain significance Single submitter
- TRPA1 p.Lys620Asn Uncertain significance Single submitter
- TRPA1 p.Met1015Thr Uncertain significance Single submitter
- TRPA1 p.Met132Val Uncertain significance Single submitter
- TRPA1 p.Met397Arg Uncertain significance Single submitter
- TRPA1 p.Met62Ile Uncertain significance Single submitter
- TRPA1 p.Met62Thr Uncertain significance Single submitter
- TRPA1 p.Met642Val Uncertain significance Single submitter
-
TRPA1 p.Met689Val
Uncertain significance
Single submitter
familial episodic pain syndrome with predominantly upper body involvement
- TRPA1 p.Met733Val Uncertain significance Single submitter
- TRPA1 p.Met801Val Uncertain significance Single submitter
- TRPA1 p.Met978Val Uncertain significance Single submitter
- TRPA1 p.Phe1056Leu Uncertain significance Single submitter
- TRPA1 p.Phe396Cys Uncertain significance Single submitter
- TRPA1 p.Phe583Ser Uncertain significance Single submitter
- TRPA1 p.Phe818Cys Uncertain significance Single submitter
- TRPA1 p.Pro674Ser Uncertain significance Single submitter
- TRPA1 p.Ser113Gly Uncertain significance Single submitter
- TRPA1 p.Ser354Phe Uncertain significance Single submitter
- TRPA1 p.Ser363Cys Uncertain significance Single submitter
- TRPA1 p.Thr382Ala Uncertain significance Single submitter
- TRPA1 p.Thr472Met Uncertain significance Single submitter
- TRPA1 p.Thr598Met Uncertain significance Single submitter
- TRPA1 p.Thr646Arg Uncertain significance Single submitter
- TRPA1 p.Thr83Asn Uncertain significance Single submitter
- TRPA1 p.Tyr22Cys Uncertain significance Single submitter
- TRPA1 p.Tyr295Phe Uncertain significance Single submitter
- TRPA1 p.Tyr840Ser Uncertain significance Single submitter
- TRPA1 p.Val20Ile Uncertain significance Single submitter
- TRPA1 p.Val20Phe Uncertain significance Single submitter
- TRPA1 p.Val383Ile Uncertain significance Single submitter
- TRPA1 p.Val839Ala Uncertain significance Single submitter
-
TRPA1 p.Val861Phe
Uncertain significance
Single submitter
familial episodic pain syndrome with predominantly upper body involvement
- TRPA1 p.Val967Phe Uncertain significance Single submitter
- TRPA1 p.Cys651Phe Uncertain significance No assertion criteria
-
TRPA1 p.Ile301Val
Uncertain significance
No assertion criteria
familial episodic pain syndrome with predominantly upper body involvement
Predictors split 22
The independent predictors disagree with each other — read with care.
- TRPA1 p.Arg458His Likely benign Multiple submitters
-
TRPA1 p.Asp339Asn
Uncertain significance
Multiple submitters
familial episodic pain syndrome with predominantly upper body involvement
- TRPA1 p.Met626Ile Likely benign Multiple submitters
- TRPA1 p.Ala122Val Conflicting Single submitter
- TRPA1 p.Ala70Thr Uncertain significance Single submitter
- TRPA1 p.Arg458Cys Uncertain significance Single submitter
- TRPA1 p.Arg996Cys Benign Single submitter
- TRPA1 p.Cys540Arg Uncertain significance Single submitter
- TRPA1 p.Gly188Ala Uncertain significance Single submitter
- TRPA1 p.Gly750Asp Uncertain significance Single submitter
- TRPA1 p.His68Tyr Uncertain significance Single submitter
- TRPA1 p.Ile1074Phe Uncertain significance Single submitter
- TRPA1 p.Leu465Ile Uncertain significance Single submitter
- TRPA1 p.Leu518Phe Uncertain significance Single submitter
- TRPA1 p.Leu667Ser Uncertain significance Single submitter
- TRPA1 p.Leu830Pro Uncertain significance Single submitter
- TRPA1 p.Pro485Ser Uncertain significance Single submitter
- TRPA1 p.Pro682Ser Uncertain significance Single submitter
- TRPA1 p.Thr241Ser Likely benign Single submitter
- TRPA1 p.Thr311Asn Likely benign Single submitter
- TRPA1 p.Thr765Met Conflicting Single submitter
- TRPA1 p.Val564Ile Uncertain significance Single submitter
All TRPA1 variants
Conflicting classifications of pathogenicity 6
- p.Ala122Val Single submitter ⚠
- p.Asp412Asn Single submitter familial episodic pain syndrome with predominantly upper body involvement ⚠
- p.Ile255Val Single submitter ⚠
- p.Ile469Val Single submitter ⚠
- p.Ser293Leu Single submitter ⚠
- p.Thr765Met Single submitter ⚠
Benign 23
- c.1530-22T>C Multiple submitters familial episodic pain syndrome with predominantly upper body involvement
- c.1644+15C>T Multiple submitters familial episodic pain syndrome with predominantly upper body involvement
- c.1905+28C>T Multiple submitters familial episodic pain syndrome with predominantly upper body involvement
- c.2869-6C>A Multiple submitters familial episodic pain syndrome with predominantly upper body involvement
- c.2938-24C>G Multiple submitters familial episodic pain syndrome with predominantly upper body involvement
- c.2938-49T>G Multiple submitters familial episodic pain syndrome with predominantly upper body involvement
- p.Asn125= Multiple submitters familial episodic pain syndrome with predominantly upper body involvement
- p.His1018Arg Multiple submitters familial episodic pain syndrome with predominantly upper body involvement
- p.Leu544= Multiple submitters familial episodic pain syndrome with predominantly upper body involvement
- p.Lys186Asn Multiple submitters familial episodic pain syndrome with predominantly upper body involvement
- p.Val299Met Multiple submitters
- p.Arg3Cys Single submitter
- p.Arg58Thr Single submitter
- p.Arg996Cys Single submitter ⚠
- p.Asn373Ile Single submitter
- p.Gly962= Single submitter
- c.1195-8del No assertion criteria TRPA1-related disorder
- c.1812-3C>T No assertion criteria TRPA1-related disorder
- p.Arg228= No assertion criteria TRPA1-related disorder
- p.Asn128= No assertion criteria TRPA1-related disorder
- p.Glu179Lys No assertion criteria TRPA1-related disorder
- p.Leu830= No assertion criteria TRPA1-related disorder
- p.Thr814= No assertion criteria TRPA1-related disorder
Benign/Likely benign 2
- c.2937+6T>C Multiple submitters
- p.Ser759= Multiple submitters
Likely benign 60
- p.Ala263= Multiple submitters
- p.Arg393Ter Multiple submitters
- p.Arg458His Multiple submitters ⚠
- p.Asn109Lys Multiple submitters
- p.Asp60= Multiple submitters
- p.Met626Ile Multiple submitters ⚠
- p.Tyr655= Multiple submitters
- c.1094-6T>C Single submitter
- c.111+15C>A Single submitter
- c.1194+8A>G Single submitter
- c.1644+12G>A Single submitter
- c.1966-19_1966-16dup Single submitter
- c.2062-10T>A Single submitter
- c.3052-5G>A Single submitter
- c.3052-6C>T Single submitter
- c.993+7A>C Single submitter
- p.Ala279= Single submitter
- p.Ala44= Single submitter
- p.Ala521= Single submitter
- p.Ala565Val Single submitter
- p.Arg127Gln Single submitter
- p.Arg3= Single submitter
- p.Arg343Cys Single submitter
- p.Arg652Ter Single submitter
- p.Arg797= Single submitter
- p.Asn411= Single submitter
- p.Asn492= Single submitter
- p.Asn513= Single submitter
- p.Asn739Ser Single submitter
- p.Asp1081Glu Single submitter
- p.Cys213= Single submitter
- p.Cys59Tyr Single submitter
- p.Gln367Arg Single submitter
- p.Gly478= Single submitter
- p.His1084Gln Single submitter
- p.His440= Single submitter
- p.His481= Single submitter
- p.Ile111Val Single submitter
- p.Ile627Val Single submitter
- p.Ile679Thr Single submitter
- p.Leu1117Pro Single submitter
- p.Leu230Ser Single submitter
- p.Leu995= Single submitter
- p.Lys620Arg Single submitter
- p.Met397Ile Single submitter
- p.Met801Leu Single submitter
- p.Pro682= Single submitter
- p.Thr241Ser Single submitter ⚠
- p.Thr274= Single submitter
- p.Thr311Asn Single submitter ⚠
- p.Tyr45Cys Single submitter
- p.Val596= Single submitter
- p.Val702= Single submitter
- c.1094-3dup No assertion criteria TRPA1-related disorder
- c.2555+10G>A No assertion criteria TRPA1-related disorder
- c.-9G>A No assertion criteria TRPA1-related disorder
- p.Ala105= No assertion criteria TRPA1-related disorder
- p.Asp639= No assertion criteria TRPA1-related disorder
- p.Leu708= No assertion criteria TRPA1-related disorder
- p.Ser113= No assertion criteria TRPA1-related disorder
Uncertain significance 128
- p.Asp339Asn Multiple submitters familial episodic pain syndrome with predominantly upper body involvement ⚠
- p.His309Tyr Multiple submitters familial episodic pain syndrome with predominantly upper body involvement ⚠
- p.His418Gln Multiple submitters ⚠
- p.Lys504Arg Multiple submitters ⚠
- p.Met1042Val Multiple submitters ⚠
- p.Ala189Asp Single submitter ⚠
- p.Ala521Val Single submitter ⚠
- p.Ala581Thr Single submitter ⚠
- p.Ala70Thr Single submitter ⚠
- p.Ala713Thr Single submitter
- p.Ala745Thr Single submitter ⚠
- p.Ala789Val Single submitter familial episodic pain syndrome with predominantly upper body involvement ⚠
- p.Arg1050Trp Single submitter
- p.Arg1102Thr Single submitter ⚠
- p.Arg343His Single submitter ⚠
- p.Arg376Cys Single submitter ⚠
- p.Arg458Cys Single submitter ⚠
- p.Arg543His Single submitter ⚠
- p.Arg58Ser Single submitter ⚠
- p.Arg652Leu Single submitter ⚠
- p.Arg694His Single submitter ⚠
- p.Arg6Gly Single submitter ⚠
- p.Asn109fs Single submitter
- p.Asn237Lys Single submitter ⚠
- p.Asn411Lys Single submitter ⚠
- p.Asn49Asp Single submitter ⚠
- p.Asn571Lys Single submitter ⚠
- p.Asn577Asp Single submitter
- p.Asn619Ser Single submitter ⚠
- p.Asn692His Single submitter familial episodic pain syndrome with predominantly upper body involvement ⚠
- p.Asp468Glu Single submitter ⚠
- p.Asp61Asn Single submitter ⚠
- p.Cys199Arg Single submitter ⚠
- p.Cys273Tyr Single submitter
- p.Cys462Arg Single submitter familial episodic pain syndrome with predominantly upper body involvement ⚠
- p.Cys540Arg Single submitter ⚠
- p.Gln1031fs Single submitter
- p.Gln423Glu Single submitter ⚠
- p.Glu107Lys Single submitter ⚠
- p.Glu16Asp Single submitter ⚠
- p.Glu41Asp Single submitter ⚠
- p.Glu657Lys Single submitter ⚠
- p.Glu93Gly Single submitter ⚠
- p.Gly121Arg Single submitter ⚠
- p.Gly188Ala Single submitter ⚠
- p.Gly209Val Single submitter ⚠
- p.Gly365Asp Single submitter ⚠
- p.Gly424Arg Single submitter ⚠
- p.Gly425Ser Single submitter ⚠
- p.Gly42Glu Single submitter ⚠
- p.Gly524Ser Single submitter ⚠
- p.Gly525Arg Single submitter ⚠
- p.Gly750Asp Single submitter ⚠
- p.His1018Ser Single submitter
- p.His589Gln Single submitter ⚠
- p.His68Tyr Single submitter ⚠
- p.Ile1074Phe Single submitter ⚠
- p.Ile111Thr Single submitter ⚠
- p.Ile171Phe Single submitter ⚠
- p.Ile171Thr Single submitter ⚠
- p.Ile459Phe Single submitter ⚠
- p.Ile656Met Single submitter ⚠
- p.Ile761Met Single submitter ⚠
- p.Ile76Asn Single submitter ⚠
- p.Ile770Met Single submitter ⚠
- p.Leu1051Pro Single submitter ⚠
- p.Leu324= Single submitter
- p.Leu465Ile Single submitter ⚠
- p.Leu480His Single submitter ⚠
- p.Leu480Phe Single submitter ⚠
- p.Leu518Phe Single submitter ⚠
- p.Leu637Ile Single submitter ⚠
- p.Leu663His Single submitter ⚠
- p.Leu667Ser Single submitter ⚠
- p.Leu730Phe Single submitter ⚠
- p.Leu769Ile Single submitter ⚠
- p.Leu830Pro Single submitter ⚠
- p.Lys196Arg Single submitter ⚠
- p.Lys337Gln Single submitter ⚠
- p.Lys446Met Single submitter
- p.Lys54Asn Single submitter ⚠
- p.Lys620Asn Single submitter ⚠
- p.Lys620fs Single submitter
- p.Met1015Thr Single submitter ⚠
- p.Met132Val Single submitter ⚠
- p.Met397Arg Single submitter ⚠
- p.Met62Ile Single submitter ⚠
- p.Met62Thr Single submitter ⚠
- p.Met642Val Single submitter ⚠
- p.Met689Val Single submitter familial episodic pain syndrome with predominantly upper body involvement ⚠
- p.Met733Val Single submitter ⚠
- p.Met801Val Single submitter ⚠
- p.Met978Val Single submitter ⚠
- p.Phe1056Leu Single submitter ⚠
- p.Phe396Cys Single submitter ⚠
- p.Phe583Ser Single submitter ⚠
- p.Phe800fs Single submitter
- p.Phe818Cys Single submitter ⚠
- p.Pro485Ser Single submitter ⚠
- p.Pro674Ser Single submitter ⚠
- p.Pro682Ser Single submitter ⚠
- p.Pro732Ala Single submitter familial episodic pain syndrome with predominantly upper body involvement
- p.Ser113Gly Single submitter ⚠
- p.Ser354Phe Single submitter ⚠
- p.Ser363Cys Single submitter ⚠
- p.Ser428Phe Single submitter
- p.Ser582fs Single submitter familial episodic pain syndrome with predominantly upper body involvement
- p.Ser781Asn Single submitter
- p.Thr382Ala Single submitter ⚠
- p.Thr472Met Single submitter ⚠
- p.Thr598Met Single submitter ⚠
- p.Thr646Arg Single submitter ⚠
- p.Thr83Asn Single submitter ⚠
- p.Trp993Ter Single submitter
- p.Tyr22Cys Single submitter ⚠
- p.Tyr295Phe Single submitter ⚠
- p.Tyr419Ter Single submitter
- p.Tyr840Ser Single submitter ⚠
- p.Tyr840Ter Single submitter
- p.Val20Ile Single submitter ⚠
- p.Val20Phe Single submitter ⚠
- p.Val383Ile Single submitter ⚠
- p.Val564Ile Single submitter ⚠
- p.Val839Ala Single submitter ⚠
- p.Val861Phe Single submitter familial episodic pain syndrome with predominantly upper body involvement ⚠
- p.Val967Phe Single submitter ⚠
- p.Cys651Phe No assertion criteria ⚠
- p.Ile301Val No assertion criteria familial episodic pain syndrome with predominantly upper body involvement ⚠