TRPC1 — 66 ClinVar variants
All ClinVar germline TRPC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
1 Likely benign · 65 Uncertain significance
Full TRPC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRPC1 p.Ala653Val Uncertain significance Single submitter
- TRPC1 p.Arg782Gln Uncertain significance Single submitter
- TRPC1 p.Arg85Lys Uncertain significance Single submitter
- TRPC1 p.Asn29Lys Uncertain significance Single submitter
-
TRPC1 p.Asn456Tyr
Uncertain significance
Single submitter
neurodevelopmental disorder
- TRPC1 p.Asn630Ser Uncertain significance Single submitter
- TRPC1 p.Asn70Lys Uncertain significance Single submitter
- TRPC1 p.Asp205Gly Uncertain significance Single submitter
- TRPC1 p.Asp36Asn Uncertain significance Single submitter
- TRPC1 p.Glu293Lys Uncertain significance Single submitter
- TRPC1 p.Gly358Ala Uncertain significance Single submitter
- TRPC1 p.His481Arg Uncertain significance Single submitter
- TRPC1 p.Ile216Val Uncertain significance Single submitter
- TRPC1 p.Ile314Ser Uncertain significance Single submitter
- TRPC1 p.Ile588Thr Uncertain significance Single submitter
- TRPC1 p.Ile691Val Uncertain significance Single submitter
- TRPC1 p.Ile775Met Uncertain significance Single submitter
- TRPC1 p.Ile90Val Uncertain significance Single submitter
- TRPC1 p.Ile99Val Uncertain significance Single submitter
- TRPC1 p.Leu11Phe Uncertain significance Single submitter
- TRPC1 p.Leu165Ser Uncertain significance Single submitter
- TRPC1 p.Leu398Arg Uncertain significance Single submitter
- TRPC1 p.Lys487Gln Uncertain significance Single submitter
- TRPC1 p.Met2Val Uncertain significance Single submitter
- TRPC1 p.Met788Ile Uncertain significance Single submitter
- TRPC1 p.Pro7Arg Uncertain significance Single submitter
- TRPC1 p.Ser16Phe Uncertain significance Single submitter
- TRPC1 p.Ser17Phe Uncertain significance Single submitter
- TRPC1 p.Ser210Phe Uncertain significance Single submitter
- TRPC1 p.Ser22Pro Uncertain significance Single submitter
- TRPC1 p.Ser248Thr Uncertain significance Single submitter
- TRPC1 p.Ser27Leu Uncertain significance Single submitter
- TRPC1 p.Ser27Pro Uncertain significance Single submitter
- TRPC1 p.Ser290Cys Uncertain significance Single submitter
- TRPC1 p.Thr289Lys Uncertain significance Single submitter
- TRPC1 p.Thr783Ala Uncertain significance Single submitter
- TRPC1 p.Thr9Arg Uncertain significance Single submitter
- TRPC1 p.Tyr671Asn Uncertain significance Single submitter
- TRPC1 p.Val40Gly Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- TRPC1 p.Ala224Val Uncertain significance Single submitter
- TRPC1 p.Ala623Thr Uncertain significance Single submitter
- TRPC1 p.Ala623Val Uncertain significance Single submitter
- TRPC1 p.Ala787Asp Uncertain significance Single submitter
- TRPC1 p.Arg169Cys Uncertain significance Single submitter
- TRPC1 p.Arg277Gln Uncertain significance Single submitter
- TRPC1 p.Arg455Cys Uncertain significance Single submitter
- TRPC1 p.Arg455His Uncertain significance Single submitter
- TRPC1 p.Arg512His Uncertain significance Single submitter
- TRPC1 p.Asn202Lys Uncertain significance Single submitter
- TRPC1 p.Glu239Asp Uncertain significance Single submitter
- TRPC1 p.Ile423Thr Uncertain significance Single submitter
- TRPC1 p.Leu426Phe Uncertain significance Single submitter
- TRPC1 p.Met227Thr Uncertain significance Single submitter
- TRPC1 p.Phe254Tyr Uncertain significance Single submitter
- TRPC1 p.Phe384Leu Uncertain significance Single submitter
- TRPC1 p.Phe515Cys Uncertain significance Single submitter
- TRPC1 p.Phe537Cys Uncertain significance Single submitter
- TRPC1 p.Pro681Ser Uncertain significance Single submitter
- TRPC1 p.Val632Met Uncertain significance Single submitter
All TRPC1 variants
Likely benign 1
- p.Ile216Met Single submitter malignant hyperthermia, susceptibility to, 1
Uncertain significance 65
- p.Ala224Val Single submitter ⚠
- p.Ala623Thr Single submitter ⚠
- p.Ala623Val Single submitter ⚠
- p.Ala653Val Single submitter ⚠
- p.Ala787Asp Single submitter ⚠
- p.Arg169Cys Single submitter ⚠
- p.Arg277Gln Single submitter ⚠
- p.Arg455Cys Single submitter ⚠
- p.Arg455His Single submitter ⚠
- p.Arg512His Single submitter ⚠
- p.Arg713Trp Single submitter
- p.Arg782Gln Single submitter ⚠
- p.Arg85Lys Single submitter ⚠
- p.Asn202Lys Single submitter ⚠
- p.Asn29Lys Single submitter ⚠
- p.Asn456Tyr Single submitter neurodevelopmental disorder ⚠
- p.Asn630Ser Single submitter ⚠
- p.Asn70Lys Single submitter ⚠
- p.Asn86His Single submitter
- p.Asp205Gly Single submitter ⚠
- p.Asp36Asn Single submitter ⚠
- p.Glu239Asp Single submitter ⚠
- p.Glu293Lys Single submitter ⚠
- p.Gly358Ala Single submitter ⚠
- p.His481Arg Single submitter ⚠
- p.Ile216Val Single submitter ⚠
- p.Ile314Ser Single submitter ⚠
- p.Ile423Thr Single submitter ⚠
- p.Ile588Thr Single submitter ⚠
- p.Ile691Val Single submitter ⚠
- p.Ile775Met Single submitter ⚠
- p.Ile90Val Single submitter ⚠
- p.Ile99Val Single submitter ⚠
- p.Leu11Phe Single submitter ⚠
- p.Leu165Ser Single submitter ⚠
- p.Leu301Ser Single submitter
- p.Leu398Arg Single submitter ⚠
- p.Leu426Phe Single submitter ⚠
- p.Lys487Gln Single submitter ⚠
- p.Met227Thr Single submitter ⚠
- p.Met2Val Single submitter ⚠
- p.Met746Ile Single submitter
- p.Met788Ile Single submitter ⚠
- p.Phe254Tyr Single submitter ⚠
- p.Phe384Leu Single submitter ⚠
- p.Phe515Cys Single submitter ⚠
- p.Phe537Cys Single submitter ⚠
- p.Pro681Ser Single submitter ⚠
- p.Pro7Arg Single submitter ⚠
- p.Ser16Phe Single submitter ⚠
- p.Ser17Phe Single submitter ⚠
- p.Ser210Phe Single submitter ⚠
- p.Ser22Pro Single submitter ⚠
- p.Ser248Thr Single submitter ⚠
- p.Ser27Leu Single submitter ⚠
- p.Ser27Pro Single submitter ⚠
- p.Ser290Cys Single submitter ⚠
- p.Ser752Arg Single submitter
- p.Thr289Lys Single submitter ⚠
- p.Thr783Ala Single submitter ⚠
- p.Thr9Arg Single submitter ⚠
- p.Tyr671Asn Single submitter ⚠
- p.Val40Gly Single submitter ⚠
- p.Val632Met Single submitter ⚠
- p.Gln324Ter No assertion criteria prostate cancer