TRPC4 — 88 ClinVar variants
All ClinVar germline TRPC4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
1 Pathogenic · 2 Benign · 2 Likely benign · 83 Uncertain significance
Full TRPC4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 65
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRPC4 p.Ala327Val Uncertain significance Single submitter
- TRPC4 p.Ala484Thr Uncertain significance Single submitter
- TRPC4 p.Ala808Thr Uncertain significance Single submitter
- TRPC4 p.Ala856Ser Uncertain significance Single submitter
- TRPC4 p.Ala856Val Uncertain significance Single submitter
- TRPC4 p.Ala876Pro Uncertain significance Single submitter
- TRPC4 p.Ala877Ser Uncertain significance Single submitter
- TRPC4 p.Arg246Gln Uncertain significance Single submitter
- TRPC4 p.Arg639Pro Uncertain significance Single submitter
- TRPC4 p.Arg684Ile Uncertain significance Single submitter
- TRPC4 p.Arg747Cys Uncertain significance Single submitter
- TRPC4 p.Arg851Leu Uncertain significance Single submitter
- TRPC4 p.Arg873His Uncertain significance Single submitter
- TRPC4 p.Arg889Gln Uncertain significance Single submitter
- TRPC4 p.Asn559Thr Uncertain significance Single submitter
- TRPC4 p.Asn862Ser Uncertain significance Single submitter
- TRPC4 p.Asn9Lys Uncertain significance Single submitter
- TRPC4 p.Asp724Gly Uncertain significance Single submitter
- TRPC4 p.Gln250His Uncertain significance Single submitter
- TRPC4 p.Gln569Pro Uncertain significance Single submitter
- TRPC4 p.Gln874His Uncertain significance Single submitter
- TRPC4 p.Gln905Pro Uncertain significance Single submitter
- TRPC4 p.Glu729Asp Uncertain significance Single submitter
- TRPC4 p.Glu827Asp Uncertain significance Single submitter
- TRPC4 p.Glu84Val Uncertain significance Single submitter
- TRPC4 p.Glu858Gln Uncertain significance Single submitter
- TRPC4 p.Glu858Gly Uncertain significance Single submitter
- TRPC4 p.Glu881Gln Uncertain significance Single submitter
- TRPC4 p.Glu913Lys Uncertain significance Single submitter
- TRPC4 p.Glu953Lys Uncertain significance Single submitter
- TRPC4 p.Glu970Ala Uncertain significance Single submitter
- TRPC4 p.Gly396Ser Uncertain significance Single submitter
- TRPC4 p.Gly890Arg Uncertain significance Single submitter
- TRPC4 p.Gly895Asp Uncertain significance Single submitter
- TRPC4 p.His969Leu Uncertain significance Single submitter
- TRPC4 p.Ile267Leu Uncertain significance Single submitter
- TRPC4 p.Ile293Val Uncertain significance Single submitter
- TRPC4 p.Ile336Val Uncertain significance Single submitter
- TRPC4 p.Ile406Met Uncertain significance Single submitter
- TRPC4 p.Ile483Val Uncertain significance Single submitter
- TRPC4 p.Ile633Thr Uncertain significance Single submitter
- TRPC4 p.Ile884Asn Uncertain significance Single submitter
- TRPC4 p.Leu203Val Uncertain significance Single submitter
- TRPC4 p.Leu244Gln Uncertain significance Single submitter
- TRPC4 p.Leu277Pro Uncertain significance Single submitter
- TRPC4 p.Lys726Arg Uncertain significance Single submitter
- TRPC4 p.Lys832Arg Uncertain significance Single submitter
- TRPC4 p.Lys925Asn Uncertain significance Single submitter
- TRPC4 p.Pro879Gln Uncertain significance Single submitter
- TRPC4 p.Ser760Phe Uncertain significance Single submitter
- TRPC4 p.Ser760Pro Uncertain significance Single submitter
- TRPC4 p.Ser768Leu Uncertain significance Single submitter
- TRPC4 p.Ser956Gly Uncertain significance Single submitter
- TRPC4 p.Thr548Ile Uncertain significance Single submitter
- TRPC4 p.Thr968Ile Uncertain significance Single submitter
- TRPC4 p.Thr974Ser Uncertain significance Single submitter
- TRPC4 p.Tyr14Cys Uncertain significance Single submitter
- TRPC4 p.Tyr959Cys Uncertain significance Single submitter
- TRPC4 p.Val109Ala Uncertain significance Single submitter
- TRPC4 p.Val23Ile Uncertain significance Single submitter
- TRPC4 p.Val40Met Uncertain significance Single submitter
- TRPC4 p.Val718Ile Uncertain significance Single submitter
- TRPC4 p.Val907Glu Uncertain significance Single submitter
- TRPC4 p.Val935Leu Uncertain significance Single submitter
-
TRPC4 p.Arg175Cys
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 14
The independent predictors disagree with each other — read with care.
- TRPC4 p.Ala720Glu Uncertain significance Single submitter
- TRPC4 p.Arg288Lys Uncertain significance Single submitter
- TRPC4 p.Arg723Thr Uncertain significance Single submitter
- TRPC4 p.Cys928Trp Uncertain significance Single submitter
- TRPC4 p.Glu555Val Uncertain significance Single submitter
- TRPC4 p.Ile18Val Uncertain significance Single submitter
- TRPC4 p.Ile22Thr Uncertain significance Single submitter
- TRPC4 p.Leu309Val Uncertain significance Single submitter
- TRPC4 p.Leu339Ile Uncertain significance Single submitter
- TRPC4 p.Met600Ile Uncertain significance Single submitter
- TRPC4 p.Phe217Leu Uncertain significance Single submitter
- TRPC4 p.Phe4Ser Uncertain significance Single submitter
- TRPC4 p.Ser212Ala Uncertain significance Single submitter
- TRPC4 p.Thr259Ser Uncertain significance Single submitter
All TRPC4 variants
Pathogenic 1
- c.379-2A>T Single submitter autism, susceptiblity to
Likely benign 2
- p.Asn786= Single submitter
- p.Ile762Val Single submitter
Uncertain significance 83
- p.Ala327Val Single submitter ⚠
- p.Ala484Thr Single submitter ⚠
- p.Ala697Thr Single submitter
- p.Ala720Glu Single submitter ⚠
- p.Ala808Thr Single submitter ⚠
- p.Ala856Ser Single submitter ⚠
- p.Ala856Val Single submitter ⚠
- p.Ala876Pro Single submitter ⚠
- p.Ala877Ser Single submitter ⚠
- p.Arg246Gln Single submitter ⚠
- p.Arg288Lys Single submitter ⚠
- p.Arg313His Single submitter
- p.Arg639Pro Single submitter ⚠
- p.Arg684Ile Single submitter ⚠
- p.Arg723Thr Single submitter ⚠
- p.Arg747Cys Single submitter ⚠
- p.Arg851Leu Single submitter ⚠
- p.Arg873His Single submitter ⚠
- p.Arg889Gln Single submitter ⚠
- p.Asn559Thr Single submitter ⚠
- p.Asn862Ser Single submitter ⚠
- p.Asn9Lys Single submitter ⚠
- p.Asp428Glu Single submitter
- p.Asp724Gly Single submitter ⚠
- p.Cys928Trp Single submitter ⚠
- p.Gln250His Single submitter ⚠
- p.Gln569Pro Single submitter ⚠
- p.Gln874His Single submitter ⚠
- p.Gln905Pro Single submitter ⚠
- p.Glu555Val Single submitter ⚠
- p.Glu729Asp Single submitter ⚠
- p.Glu827Asp Single submitter ⚠
- p.Glu84Val Single submitter ⚠
- p.Glu858Gln Single submitter ⚠
- p.Glu858Gly Single submitter ⚠
- p.Glu881Gln Single submitter ⚠
- p.Glu913Lys Single submitter ⚠
- p.Glu953Lys Single submitter ⚠
- p.Glu970Ala Single submitter ⚠
- p.Gly396Ser Single submitter ⚠
- p.Gly890Arg Single submitter ⚠
- p.Gly895Asp Single submitter ⚠
- p.His969Leu Single submitter ⚠
- p.Ile18Val Single submitter ⚠
- p.Ile22Thr Single submitter ⚠
- p.Ile267Leu Single submitter ⚠
- p.Ile293Val Single submitter ⚠
- p.Ile336Val Single submitter ⚠
- p.Ile406Met Single submitter ⚠
- p.Ile483Val Single submitter ⚠
- p.Ile633Thr Single submitter ⚠
- p.Ile76Leu Single submitter
- p.Ile884Asn Single submitter ⚠
- p.Leu203Val Single submitter ⚠
- p.Leu244Gln Single submitter ⚠
- p.Leu277Pro Single submitter ⚠
- p.Leu309Val Single submitter ⚠
- p.Leu339Ile Single submitter ⚠
- p.Lys726Arg Single submitter ⚠
- p.Lys832Arg Single submitter ⚠
- p.Lys925Asn Single submitter ⚠
- p.Met600Ile Single submitter ⚠
- p.Phe217Leu Single submitter ⚠
- p.Phe4Ser Single submitter ⚠
- p.Pro879Gln Single submitter ⚠
- p.Ser212Ala Single submitter ⚠
- p.Ser760Phe Single submitter ⚠
- p.Ser760Pro Single submitter ⚠
- p.Ser768Leu Single submitter ⚠
- p.Ser956Gly Single submitter ⚠
- p.Thr259Ser Single submitter ⚠
- p.Thr548Ile Single submitter ⚠
- p.Thr968Ile Single submitter ⚠
- p.Thr974Ser Single submitter ⚠
- p.Tyr14Cys Single submitter ⚠
- p.Tyr959Cys Single submitter ⚠
- p.Val109Ala Single submitter ⚠
- p.Val23Ile Single submitter ⚠
- p.Val40Met Single submitter ⚠
- p.Val718Ile Single submitter ⚠
- p.Val907Glu Single submitter ⚠
- p.Val935Leu Single submitter ⚠
- p.Arg175Cys No assertion criteria prostate cancer ⚠