TRPC5 — 152 ClinVar variants
All ClinVar germline TRPC5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →
1 Conflicting · 4 Benign · 64 Likely benign · 83 Uncertain significance
Full TRPC5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 83
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRPC5 p.Ala929Thr Uncertain significance Single submitter
- TRPC5 p.Arg120Gln Uncertain significance Single submitter
- TRPC5 p.Arg263Lys Uncertain significance Single submitter
- TRPC5 p.Arg464Cys Uncertain significance Single submitter
- TRPC5 p.Arg697Thr Uncertain significance Single submitter
- TRPC5 p.Asn10Ser Uncertain significance Single submitter
- TRPC5 p.Asn38Ser Uncertain significance Single submitter
- TRPC5 p.Asn900Thr Uncertain significance Single submitter
- TRPC5 p.Cys65Arg Uncertain significance Single submitter
- TRPC5 p.Gln873His Uncertain significance Single submitter
-
TRPC5 p.Gln914Glu
Uncertain significance
Single submitter
TRPC5-related disorder
- TRPC5 p.Glu156Lys Uncertain significance Single submitter
- TRPC5 p.Glu892Lys Uncertain significance Single submitter
- TRPC5 p.Gly110Asp Uncertain significance Single submitter
- TRPC5 p.Gly123Arg Uncertain significance Single submitter
- TRPC5 p.Gly43Arg Uncertain significance Single submitter
- TRPC5 p.Gly889Ala Uncertain significance Single submitter
- TRPC5 p.His285Gln Uncertain significance Single submitter
- TRPC5 p.His387Arg Uncertain significance Single submitter
- TRPC5 p.Ile63Val Uncertain significance Single submitter
- TRPC5 p.Lys459Glu Uncertain significance Single submitter
-
TRPC5 p.Lys7Gln
Uncertain significance
Single submitter
TRPC5-related disorder
- TRPC5 p.Met624Thr Uncertain significance Single submitter
- TRPC5 p.Met864Val Uncertain significance Single submitter
- TRPC5 p.Met86Val Uncertain significance Single submitter
- TRPC5 p.Phe237Leu Uncertain significance Single submitter
- TRPC5 p.Phe677Leu Uncertain significance Single submitter
- TRPC5 p.Phe947Ser Uncertain significance Single submitter
- TRPC5 p.Pro352Arg Uncertain significance Single submitter
- TRPC5 p.Thr129Asn Uncertain significance Single submitter
- TRPC5 p.Thr134Met Uncertain significance Single submitter
- TRPC5 p.Val233Met Uncertain significance Single submitter
-
TRPC5 p.Ala912Thr
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Arg260Trp
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Arg545Thr
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Asp424His
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Cys876Tyr
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Gln779Glu
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Glu952Lys
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Gly689Ser
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.His855Arg
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Met131Ile
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Met131Thr
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Met422Thr
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Met877Ile
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Phe576Tyr
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Ser666Asn
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Ser925Pro
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Ser93Arg
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Val182Leu
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Val9Phe
Uncertain significance
No assertion criteria
TRPC5-related disorder
Predictors split 31
The independent predictors disagree with each other — read with care.
-
TRPC5 p.Arg175Cys
Uncertain significance
Single submitter
intellectual disability
- TRPC5 p.Arg17Cys Uncertain significance Single submitter
- TRPC5 p.Arg17His Uncertain significance Single submitter
- TRPC5 p.Arg17Leu Uncertain significance Single submitter
-
TRPC5 p.Arg222Cys
Uncertain significance
Single submitter
TRPC5-related disorder
- TRPC5 p.Arg691Gln Uncertain significance Single submitter
- TRPC5 p.Arg694Cys Uncertain significance Single submitter
- TRPC5 p.Arg694His Likely benign Single submitter
- TRPC5 p.Arg791Trp Uncertain significance Single submitter
- TRPC5 p.Arg835Cys Uncertain significance Single submitter
- TRPC5 p.Ile337Thr Uncertain significance Single submitter
- TRPC5 p.Lys8Thr Uncertain significance Single submitter
- TRPC5 p.Phe681Leu Uncertain significance Single submitter
- TRPC5 p.Pro399His Uncertain significance Single submitter
- TRPC5 p.Ser769Asn Uncertain significance Single submitter
- TRPC5 p.Ser773Cys Uncertain significance Single submitter
- TRPC5 p.Ser884Phe Uncertain significance Single submitter
- TRPC5 p.Ser937Phe Uncertain significance Single submitter
- TRPC5 p.Tyr14His Uncertain significance Single submitter
- TRPC5 p.Val579Ala Uncertain significance Single submitter
- TRPC5 p.Val716Ile Uncertain significance Single submitter
-
TRPC5 p.Ala546Asp
Likely benign
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Arg120Trp
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Arg191His
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Arg324Gln
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Arg691Trp
Likely benign
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Arg702His
Likely benign
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Asp16Glu
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Glu87Lys
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Ile431Met
Uncertain significance
No assertion criteria
TRPC5-related disorder
-
TRPC5 p.Ser924Cys
Uncertain significance
No assertion criteria
TRPC5-related disorder
All TRPC5 variants
Conflicting classifications of pathogenicity 1
- p.Leu738Ile Single submitter ⚠
Benign 4
Likely benign 64
- p.Arg694His Single submitter ⚠
- p.Asp280= Single submitter
- p.His473= Single submitter
- p.Leu447= Single submitter
- p.Phe319= Single submitter
- p.Ser860= Single submitter
- p.Val328= Single submitter
- c.1238-7del No assertion criteria TRPC5-related disorder
- c.1238-8T>C No assertion criteria TRPC5-related disorder
- c.1377+6T>C No assertion criteria TRPC5-related disorder
- c.1700+7C>T No assertion criteria TRPC5-related disorder
- c.1897-3T>C No assertion criteria TRPC5-related disorder
- c.1897-5C>T No assertion criteria TRPC5-related disorder
- c.2232+9A>G No assertion criteria TRPC5-related disorder
- c.-10G>C No assertion criteria TRPC5-related disorder
- p.Ala239= No assertion criteria TRPC5-related disorder
- p.Ala478= No assertion criteria TRPC5-related disorder
- p.Ala546Asp No assertion criteria TRPC5-related disorder ⚠
- p.Ala891= No assertion criteria TRPC5-related disorder
- p.Ala929= No assertion criteria TRPC5-related disorder
- p.Arg120= No assertion criteria TRPC5-related disorder
- p.Arg222= No assertion criteria TRPC5-related disorder
- p.Arg466= No assertion criteria TRPC5-related disorder
- p.Arg643= No assertion criteria TRPC5-related disorder
- p.Arg691Trp No assertion criteria TRPC5-related disorder ⚠
- p.Arg702His No assertion criteria TRPC5-related disorder ⚠
- p.Arg791= No assertion criteria TRPC5-related disorder
- p.Asn10= No assertion criteria TRPC5-related disorder
- p.Asn62= No assertion criteria TRPC5-related disorder
- p.Asn763= No assertion criteria TRPC5-related disorder
- p.Asn91= No assertion criteria TRPC5-related disorder
- p.Asp688= No assertion criteria TRPC5-related disorder
- p.Asp781= No assertion criteria TRPC5-related disorder
- p.Cys65= No assertion criteria TRPC5-related disorder
- p.Gln386= No assertion criteria TRPC5-related disorder
- p.Gln711= No assertion criteria TRPC5-related disorder
- p.Glu26= No assertion criteria TRPC5-related disorder
- p.Gly110= No assertion criteria TRPC5-related disorder
- p.Gly338= No assertion criteria TRPC5-related disorder
- p.Gly357= No assertion criteria TRPC5-related disorder
- p.Gly789= No assertion criteria TRPC5-related disorder
- p.Ile18= No assertion criteria TRPC5-related disorder
- p.Ile199= No assertion criteria TRPC5-related disorder
- p.Ile268= No assertion criteria TRPC5-related disorder
- p.Ile547= No assertion criteria TRPC5-related disorder
- p.Ile621= No assertion criteria TRPC5-related disorder
- p.Ile63= No assertion criteria TRPC5-related disorder
- p.Leu20= No assertion criteria TRPC5-related disorder
- p.Leu230= No assertion criteria TRPC5-related disorder
- p.Leu290= No assertion criteria TRPC5-related disorder
- p.Leu437= No assertion criteria TRPC5-related disorder
- p.Leu535= No assertion criteria TRPC5-related disorder
- p.Pro19= No assertion criteria TRPC5-related disorder
- p.Pro305= No assertion criteria TRPC5-related disorder
- p.Pro840= No assertion criteria TRPC5-related disorder
- p.Ser122= No assertion criteria TRPC5-related disorder
- p.Ser261= No assertion criteria TRPC5-related disorder
- p.Ser943= No assertion criteria TRPC5-related disorder
- p.Thr47= No assertion criteria TRPC5-related disorder
- p.Thr475= No assertion criteria TRPC5-related disorder
- p.Thr772= No assertion criteria TRPC5-related disorder
- p.Tyr430= No assertion criteria TRPC5-related disorder
- p.Tyr59= No assertion criteria TRPC5-related disorder
- p.Val182= No assertion criteria TRPC5-related disorder
Uncertain significance 83
- p.Ala929Thr Single submitter ⚠
- p.Arg120Gln Single submitter ⚠
- p.Arg175Cys Single submitter intellectual disability ⚠
- p.Arg17Cys Single submitter ⚠
- p.Arg17His Single submitter ⚠
- p.Arg17Leu Single submitter ⚠
- p.Arg222Cys Single submitter TRPC5-related disorder ⚠
- p.Arg263Lys Single submitter ⚠
- p.Arg464Cys Single submitter ⚠
- p.Arg691Gln Single submitter ⚠
- p.Arg694Cys Single submitter ⚠
- p.Arg697Thr Single submitter ⚠
- p.Arg791Trp Single submitter ⚠
- p.Arg835Cys Single submitter ⚠
- p.Asn10Ser Single submitter ⚠
- p.Asn38Ser Single submitter ⚠
- p.Asn900Thr Single submitter ⚠
- p.Cys65Arg Single submitter ⚠
- p.Gln873His Single submitter ⚠
- p.Gln914Glu Single submitter TRPC5-related disorder ⚠
- p.Glu156Lys Single submitter ⚠
- p.Glu892Lys Single submitter ⚠
- p.Gly110Asp Single submitter ⚠
- p.Gly123Arg Single submitter ⚠
- p.Gly43Arg Single submitter ⚠
- p.Gly889Ala Single submitter ⚠
- p.His285Gln Single submitter ⚠
- p.His387Arg Single submitter ⚠
- p.Ile337Thr Single submitter ⚠
- p.Ile63Val Single submitter ⚠
- p.Leu801= Single submitter
- p.Lys459Glu Single submitter ⚠
- p.Lys7Gln Single submitter TRPC5-related disorder ⚠
- p.Lys8Thr Single submitter ⚠
- p.Met624Thr Single submitter ⚠
- p.Met864Val Single submitter ⚠
- p.Met86Val Single submitter ⚠
- p.Phe237Leu Single submitter ⚠
- p.Phe677Leu Single submitter ⚠
- p.Phe681Leu Single submitter ⚠
- p.Phe947Ser Single submitter ⚠
- p.Pro352Arg Single submitter ⚠
- p.Pro399His Single submitter ⚠
- p.Ser769Asn Single submitter ⚠
- p.Ser773Cys Single submitter ⚠
- p.Ser884Phe Single submitter ⚠
- p.Ser937Phe Single submitter ⚠
- p.Thr129Asn Single submitter ⚠
- p.Thr134Met Single submitter ⚠
- p.Tyr14His Single submitter ⚠
- p.Val233Met Single submitter ⚠
- p.Val579Ala Single submitter ⚠
- p.Val716Ile Single submitter ⚠
- p.Ala912Thr No assertion criteria TRPC5-related disorder ⚠
- p.Arg120Trp No assertion criteria TRPC5-related disorder ⚠
- p.Arg191His No assertion criteria TRPC5-related disorder ⚠
- p.Arg260Trp No assertion criteria TRPC5-related disorder ⚠
- p.Arg324Gln No assertion criteria TRPC5-related disorder ⚠
- p.Arg545Thr No assertion criteria TRPC5-related disorder ⚠
- p.Asn679del No assertion criteria TRPC5-related disorder
- p.Asp16Glu No assertion criteria TRPC5-related disorder ⚠
- p.Asp424His No assertion criteria TRPC5-related disorder ⚠
- p.Cys876Tyr No assertion criteria TRPC5-related disorder ⚠
- p.Gln779Glu No assertion criteria TRPC5-related disorder ⚠
- p.Glu87Lys No assertion criteria TRPC5-related disorder ⚠
- p.Glu952Lys No assertion criteria TRPC5-related disorder ⚠
- p.Gly689Ser No assertion criteria TRPC5-related disorder ⚠
- p.His735fs No assertion criteria TRPC5-related disorder
- p.His855Arg No assertion criteria TRPC5-related disorder ⚠
- p.Ile431Met No assertion criteria TRPC5-related disorder ⚠
- p.Met131Ile No assertion criteria TRPC5-related disorder ⚠
- p.Met131Thr No assertion criteria TRPC5-related disorder ⚠
- p.Met422Thr No assertion criteria TRPC5-related disorder ⚠
- p.Met877Ile No assertion criteria TRPC5-related disorder ⚠
- p.Phe576Tyr No assertion criteria TRPC5-related disorder ⚠
- p.Ser122Thr No assertion criteria TRPC5-related disorder
- p.Ser666Asn No assertion criteria TRPC5-related disorder ⚠
- p.Ser798fs No assertion criteria TRPC5-related disorder
- p.Ser924Cys No assertion criteria TRPC5-related disorder ⚠
- p.Ser925Pro No assertion criteria TRPC5-related disorder ⚠
- p.Ser93Arg No assertion criteria TRPC5-related disorder ⚠
- p.Val182Leu No assertion criteria TRPC5-related disorder ⚠
- p.Val9Phe No assertion criteria TRPC5-related disorder ⚠