TRPC7 — 98 ClinVar variants
All ClinVar germline TRPC7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 91 flagged for review →
1 Likely benign · 97 Uncertain significance
Full TRPC7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 91
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 69
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRPC7 p.Ala109Val Uncertain significance Single submitter
- TRPC7 p.Ala545Thr Uncertain significance Single submitter
- TRPC7 p.Ala607Thr Uncertain significance Single submitter
- TRPC7 p.Ala737Thr Uncertain significance Single submitter
- TRPC7 p.Ala737Val Uncertain significance Single submitter
- TRPC7 p.Ala760Val Uncertain significance Single submitter
- TRPC7 p.Arg105Gln Uncertain significance Single submitter
- TRPC7 p.Arg12His Uncertain significance Single submitter
- TRPC7 p.Arg208Pro Uncertain significance Single submitter
- TRPC7 p.Arg251Lys Uncertain significance Single submitter
- TRPC7 p.Arg305His Uncertain significance Single submitter
- TRPC7 p.Arg409Gln Uncertain significance Single submitter
- TRPC7 p.Arg489Cys Uncertain significance Single submitter
- TRPC7 p.Arg605Gln Uncertain significance Single submitter
- TRPC7 p.Arg855Lys Uncertain significance Single submitter
- TRPC7 p.Asn673Lys Uncertain significance Single submitter
- TRPC7 p.Asp164His Uncertain significance Single submitter
- TRPC7 p.Asp262Glu Uncertain significance Single submitter
- TRPC7 p.Asp641Asn Uncertain significance Single submitter
- TRPC7 p.Asp815Gly Uncertain significance Single submitter
- TRPC7 p.Asp852His Uncertain significance Single submitter
- TRPC7 p.Cys73Ser Uncertain significance Single submitter
- TRPC7 p.Gln11His Uncertain significance Single submitter
- TRPC7 p.Gln144Arg Uncertain significance Single submitter
- TRPC7 p.Gln175Arg Uncertain significance Single submitter
- TRPC7 p.Gln346Glu Uncertain significance Single submitter
- TRPC7 p.Gln829Glu Uncertain significance Single submitter
- TRPC7 p.Glu205Asp Uncertain significance Single submitter
- TRPC7 p.Glu236Lys Uncertain significance Single submitter
- TRPC7 p.Glu338Asp Uncertain significance Single submitter
- TRPC7 p.Glu460Asp Uncertain significance Single submitter
- TRPC7 p.Glu617Gly Uncertain significance Single submitter
- TRPC7 p.Glu646Lys Uncertain significance Single submitter
- TRPC7 p.Glu766Gly Uncertain significance Single submitter
- TRPC7 p.Gly477Ala Uncertain significance Single submitter
- TRPC7 p.Gly573Arg Uncertain significance Single submitter
- TRPC7 p.His853Tyr Uncertain significance Single submitter
- TRPC7 p.Ile558Val Uncertain significance Single submitter
- TRPC7 p.Ile56Ser Uncertain significance Single submitter
- TRPC7 p.Ile730Leu Uncertain significance Single submitter
- TRPC7 p.Leu170Pro Uncertain significance Single submitter
- TRPC7 p.Leu308Gln Uncertain significance Single submitter
- TRPC7 p.Leu732Phe Uncertain significance Single submitter
- TRPC7 p.Lys100Met Uncertain significance Single submitter
- TRPC7 p.Met727Thr Uncertain significance Single submitter
- TRPC7 p.Phe482Leu Uncertain significance Single submitter
- TRPC7 p.Phe490Ile Uncertain significance Single submitter
- TRPC7 p.Phe565Ser Uncertain significance Single submitter
- TRPC7 p.Phe753Ile Uncertain significance Single submitter
- TRPC7 p.Pro373Leu Uncertain significance Single submitter
- TRPC7 p.Pro567Ala Uncertain significance Single submitter
- TRPC7 p.Pro713Ser Uncertain significance Single submitter
- TRPC7 p.Ser307Cys Uncertain significance Single submitter
- TRPC7 p.Ser383Gly Uncertain significance Single submitter
- TRPC7 p.Thr257Ser Uncertain significance Single submitter
- TRPC7 p.Thr497Met Uncertain significance Single submitter
- TRPC7 p.Thr68Asn Uncertain significance Single submitter
- TRPC7 p.Trp459Arg Uncertain significance Single submitter
- TRPC7 p.Tyr821Cys Uncertain significance Single submitter
- TRPC7 p.Val277Leu Uncertain significance Single submitter
- TRPC7 p.Val350Leu Uncertain significance Single submitter
- TRPC7 p.Val389Ala Uncertain significance Single submitter
- TRPC7 p.Val404Met Uncertain significance Single submitter
- TRPC7 p.Val467Met Uncertain significance Single submitter
- TRPC7 p.Val503Ala Uncertain significance Single submitter
- TRPC7 p.Val503Met Uncertain significance Single submitter
- TRPC7 p.Val549Leu Uncertain significance Single submitter
- TRPC7 p.Val651Ile Uncertain significance Single submitter
- TRPC7 p.Val658Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- TRPC7 p.Ala30Ser Uncertain significance Single submitter
- TRPC7 p.Ala484Val Uncertain significance Single submitter
- TRPC7 p.Ala81Ser Uncertain significance Single submitter
- TRPC7 p.Arg189Cys Uncertain significance Single submitter
- TRPC7 p.Arg344His Uncertain significance Single submitter
- TRPC7 p.Arg46Ser Uncertain significance Single submitter
- TRPC7 p.Arg605Pro Uncertain significance Single submitter
- TRPC7 p.Arg786Gln Uncertain significance Single submitter
- TRPC7 p.Asn562Ser Uncertain significance Single submitter
- TRPC7 p.Asp108Asn Uncertain significance Single submitter
- TRPC7 p.Asp155Asn Uncertain significance Single submitter
- TRPC7 p.Gln79His Uncertain significance Single submitter
- TRPC7 p.Glu318Lys Uncertain significance Single submitter
- TRPC7 p.Glu461Lys Uncertain significance Single submitter
- TRPC7 p.Gly158Ser Uncertain significance Single submitter
- TRPC7 p.Ile595Thr Uncertain significance Single submitter
- TRPC7 p.Met491Ile Uncertain significance Single submitter
- TRPC7 p.Met660Thr Uncertain significance Single submitter
- TRPC7 p.Phe436Leu Uncertain significance Single submitter
- TRPC7 p.Phe71Leu Uncertain significance Single submitter
- TRPC7 p.Pro129Leu Uncertain significance Single submitter
- TRPC7 p.Val389Leu Uncertain significance Single submitter
All TRPC7 variants
Likely benign 1
- p.Asn657= Single submitter
Uncertain significance 97
- p.Ala109Val Single submitter ⚠
- p.Ala228Thr Single submitter
- p.Ala30Ser Single submitter ⚠
- p.Ala484Val Single submitter ⚠
- p.Ala545Thr Single submitter ⚠
- p.Ala607Thr Single submitter ⚠
- p.Ala737Thr Single submitter ⚠
- p.Ala737Val Single submitter ⚠
- p.Ala760Val Single submitter ⚠
- p.Ala81Ser Single submitter ⚠
- p.Arg105Gln Single submitter ⚠
- p.Arg12His Single submitter ⚠
- p.Arg13Trp Single submitter
- p.Arg189Cys Single submitter ⚠
- p.Arg208Pro Single submitter ⚠
- p.Arg251Lys Single submitter ⚠
- p.Arg305His Single submitter ⚠
- p.Arg344His Single submitter ⚠
- p.Arg409Gln Single submitter ⚠
- p.Arg46Ser Single submitter ⚠
- p.Arg489Cys Single submitter ⚠
- p.Arg605Gln Single submitter ⚠
- p.Arg605Pro Single submitter ⚠
- p.Arg786Gln Single submitter ⚠
- p.Arg855Lys Single submitter ⚠
- p.Asn34Lys Single submitter
- p.Asn562Ser Single submitter ⚠
- p.Asn673Lys Single submitter ⚠
- p.Asp108Asn Single submitter ⚠
- p.Asp155Asn Single submitter ⚠
- p.Asp164His Single submitter ⚠
- p.Asp262Glu Single submitter ⚠
- p.Asp641Asn Single submitter ⚠
- p.Asp815Gly Single submitter ⚠
- p.Asp852His Single submitter ⚠
- p.Cys73Ser Single submitter ⚠
- p.Gln11His Single submitter ⚠
- p.Gln144Arg Single submitter ⚠
- p.Gln175Arg Single submitter ⚠
- p.Gln346Glu Single submitter ⚠
- p.Gln79His Single submitter ⚠
- p.Gln829Glu Single submitter ⚠
- p.Glu205Asp Single submitter ⚠
- p.Glu236Lys Single submitter ⚠
- p.Glu318Lys Single submitter ⚠
- p.Glu338Asp Single submitter ⚠
- p.Glu460Asp Single submitter ⚠
- p.Glu461Lys Single submitter ⚠
- p.Glu617Gly Single submitter ⚠
- p.Glu646Lys Single submitter ⚠
- p.Glu766Gly Single submitter ⚠
- p.Glu803Gln Single submitter
- p.Gly134Asp Single submitter
- p.Gly158Ser Single submitter ⚠
- p.Gly477Ala Single submitter ⚠
- p.Gly573Arg Single submitter ⚠
- p.His853Tyr Single submitter ⚠
- p.Ile558Val Single submitter ⚠
- p.Ile56Ser Single submitter ⚠
- p.Ile595Thr Single submitter ⚠
- p.Ile730Leu Single submitter ⚠
- p.Leu170Pro Single submitter ⚠
- p.Leu308Gln Single submitter ⚠
- p.Leu732Phe Single submitter ⚠
- p.Lys100Met Single submitter ⚠
- p.Met491Ile Single submitter ⚠
- p.Met660Thr Single submitter ⚠
- p.Met727Thr Single submitter ⚠
- p.Phe436Leu Single submitter ⚠
- p.Phe482Leu Single submitter ⚠
- p.Phe490Ile Single submitter ⚠
- p.Phe565Ser Single submitter ⚠
- p.Phe71Leu Single submitter ⚠
- p.Phe753Ile Single submitter ⚠
- p.Pro129Leu Single submitter ⚠
- p.Pro373Leu Single submitter ⚠
- p.Pro567Ala Single submitter ⚠
- p.Pro713Ser Single submitter ⚠
- p.Ser307Cys Single submitter ⚠
- p.Ser383Gly Single submitter ⚠
- p.Thr257Ser Single submitter ⚠
- p.Thr497Met Single submitter ⚠
- p.Thr68Asn Single submitter ⚠
- p.Thr94Met Single submitter
- p.Trp459Arg Single submitter ⚠
- p.Tyr821Cys Single submitter ⚠
- p.Val277Leu Single submitter ⚠
- p.Val350Leu Single submitter ⚠
- p.Val389Ala Single submitter ⚠
- p.Val389Leu Single submitter ⚠
- p.Val404Met Single submitter ⚠
- p.Val467Met Single submitter ⚠
- p.Val503Ala Single submitter ⚠
- p.Val503Met Single submitter ⚠
- p.Val549Leu Single submitter ⚠
- p.Val651Ile Single submitter ⚠
- p.Val658Ile Single submitter ⚠