TRPV2 — 95 ClinVar variants
All ClinVar germline TRPV2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →
1 Benign · 3 Likely benign · 91 Uncertain significance
Full TRPV2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 87
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 70
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRPV2 p.Ala236Ser Uncertain significance Single submitter
- TRPV2 p.Ala276Ser Uncertain significance Single submitter
- TRPV2 p.Ala278Gly Uncertain significance Single submitter
- TRPV2 p.Ala51Thr Uncertain significance Single submitter
- TRPV2 p.Arg162Gln Uncertain significance Single submitter
- TRPV2 p.Arg196Cys Uncertain significance Single submitter
- TRPV2 p.Arg290Cys Uncertain significance Single submitter
- TRPV2 p.Arg326Gln Uncertain significance Single submitter
- TRPV2 p.Arg369Gly Uncertain significance Single submitter
- TRPV2 p.Arg48Gln Uncertain significance Single submitter
- TRPV2 p.Arg48Trp Uncertain significance Single submitter
- TRPV2 p.Arg533Gln Uncertain significance Single submitter
- TRPV2 p.Arg73Gln Uncertain significance Single submitter
- TRPV2 p.Arg76Gln Uncertain significance Single submitter
- TRPV2 p.Arg85Gln Uncertain significance Single submitter
- TRPV2 p.Asn570Ser Uncertain significance Single submitter
- TRPV2 p.Asp107Asn Uncertain significance Single submitter
- TRPV2 p.Asp159Asn Uncertain significance Single submitter
- TRPV2 p.Asp748Asn Uncertain significance Single submitter
- TRPV2 p.Cys349Tyr Uncertain significance Single submitter
- TRPV2 p.Cys678Tyr Uncertain significance Single submitter
- TRPV2 p.Gln239Arg Uncertain significance Single submitter
- TRPV2 p.Gln762Arg Uncertain significance Single submitter
- TRPV2 p.Glu20Lys Uncertain significance Single submitter
- TRPV2 p.Glu426Asp Uncertain significance Single submitter
- TRPV2 p.Glu46Gly Uncertain significance Single submitter
- TRPV2 p.Glu46Lys Uncertain significance Single submitter
- TRPV2 p.Glu559Gly Uncertain significance Single submitter
- TRPV2 p.Glu584Lys Uncertain significance Single submitter
- TRPV2 p.Glu670Asp Uncertain significance Single submitter
- TRPV2 p.Glu715Asp Uncertain significance Single submitter
- TRPV2 p.Glu752Asp Uncertain significance Single submitter
- TRPV2 p.Gly35Arg Uncertain significance Single submitter
- TRPV2 p.Gly449Ser Uncertain significance Single submitter
- TRPV2 p.Gly580Arg Uncertain significance Single submitter
- TRPV2 p.Gly580Glu Uncertain significance Single submitter
- TRPV2 p.Gly592Ser Uncertain significance Single submitter
- TRPV2 p.Gly620Ser Uncertain significance Single submitter
- TRPV2 p.Gly63Arg Uncertain significance Single submitter
- TRPV2 p.Gly65Ser Uncertain significance Single submitter
- TRPV2 p.His250Arg Uncertain significance Single submitter
- TRPV2 p.Ile439Met Uncertain significance Single submitter
- TRPV2 p.Ile463Thr Uncertain significance Single submitter
- TRPV2 p.Ile666Met Uncertain significance Single submitter
- TRPV2 p.Leu280Phe Uncertain significance Single submitter
- TRPV2 p.Leu447Phe Uncertain significance Single submitter
- TRPV2 p.Lys117Asn Uncertain significance Single submitter
- TRPV2 p.Lys200Asn Uncertain significance Single submitter
- TRPV2 p.Met578Ile Uncertain significance Single submitter
- TRPV2 p.Phe50Leu Uncertain significance Single submitter
- TRPV2 p.Pro297Thr Uncertain significance Single submitter
- TRPV2 p.Pro365Gln Uncertain significance Single submitter
- TRPV2 p.Pro365Ser Uncertain significance Single submitter
- TRPV2 p.Pro4Leu Uncertain significance Single submitter
- TRPV2 p.Pro4Ser Uncertain significance Single submitter
- TRPV2 p.Pro69Leu Uncertain significance Single submitter
- TRPV2 p.Ser102Gly Uncertain significance Single submitter
- TRPV2 p.Ser464Leu Uncertain significance Single submitter
- TRPV2 p.Ser99Thr Uncertain significance Single submitter
- TRPV2 p.Thr434Met Uncertain significance Single submitter
- TRPV2 p.Thr514Ala Uncertain significance Single submitter
- TRPV2 p.Thr717Met Uncertain significance Single submitter
- TRPV2 p.Trp455Arg Uncertain significance Single submitter
- TRPV2 p.Trp455Leu Uncertain significance Single submitter
- TRPV2 p.Trp507Cys Uncertain significance Single submitter
- TRPV2 p.Tyr513Cys Uncertain significance Single submitter
- TRPV2 p.Val372Ile Uncertain significance Single submitter
- TRPV2 p.Val448Met Uncertain significance Single submitter
- TRPV2 p.Val758Ile Uncertain significance Single submitter
- TRPV2 p.Val83Gly Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- TRPV2 p.Ala236Thr Uncertain significance Single submitter
- TRPV2 p.Ala502Thr Uncertain significance Single submitter
- TRPV2 p.Ala550Thr Uncertain significance Single submitter
- TRPV2 p.Arg279Cys Uncertain significance Single submitter
- TRPV2 p.Arg337Trp Uncertain significance Single submitter
- TRPV2 p.Arg533Trp Uncertain significance Single submitter
- TRPV2 p.Arg85Trp Uncertain significance Single submitter
- TRPV2 p.Asp142His Uncertain significance Single submitter
- TRPV2 p.Asp695Gly Uncertain significance Single submitter
- TRPV2 p.Glu308Lys Uncertain significance Single submitter
- TRPV2 p.Glu670Ala Uncertain significance Single submitter
- TRPV2 p.Ile169Val Uncertain significance Single submitter
- TRPV2 p.Ile404Met Uncertain significance Single submitter
- TRPV2 p.Leu499Arg Uncertain significance Single submitter
- TRPV2 p.Ser430Pro Uncertain significance Single submitter
- TRPV2 p.Ser524Gly Uncertain significance Single submitter
- TRPV2 p.Trp462Cys Uncertain significance Single submitter
All TRPV2 variants
Benign 1
- c.1351-4G>A Single submitter
Likely benign 3
- p.His617Arg Single submitter
- p.Pro569Ser Single submitter
- p.Val427Ala Single submitter
Uncertain significance 91
- p.Ala236Ser Single submitter ⚠
- p.Ala236Thr Single submitter ⚠
- p.Ala276Ser Single submitter ⚠
- p.Ala278Gly Single submitter ⚠
- p.Ala502Thr Single submitter ⚠
- p.Ala51Thr Single submitter ⚠
- p.Ala550Thr Single submitter ⚠
- p.Ala82Glu Single submitter
- p.Arg162Gln Single submitter ⚠
- p.Arg196Cys Single submitter ⚠
- p.Arg279Cys Single submitter ⚠
- p.Arg290Cys Single submitter ⚠
- p.Arg326Gln Single submitter ⚠
- p.Arg337Trp Single submitter ⚠
- p.Arg369Gly Single submitter ⚠
- p.Arg48Gln Single submitter ⚠
- p.Arg48Trp Single submitter ⚠
- p.Arg533Gln Single submitter ⚠
- p.Arg533Trp Single submitter ⚠
- p.Arg73Gln Single submitter ⚠
- p.Arg76Gln Single submitter ⚠
- p.Arg85Gln Single submitter ⚠
- p.Arg85Trp Single submitter ⚠
- p.Asn570Ser Single submitter ⚠
- p.Asp107Asn Single submitter ⚠
- p.Asp107Gly Single submitter
- p.Asp142His Single submitter ⚠
- p.Asp159Asn Single submitter ⚠
- p.Asp695Gly Single submitter ⚠
- p.Asp699Glu Single submitter
- p.Asp748Asn Single submitter ⚠
- p.Cys349Tyr Single submitter ⚠
- p.Cys678Tyr Single submitter ⚠
- p.Gln239Arg Single submitter ⚠
- p.Gln762Arg Single submitter ⚠
- p.Glu20Lys Single submitter ⚠
- p.Glu308Lys Single submitter ⚠
- p.Glu426Asp Single submitter ⚠
- p.Glu46Gly Single submitter ⚠
- p.Glu46Lys Single submitter ⚠
- p.Glu559Gly Single submitter ⚠
- p.Glu584Lys Single submitter ⚠
- p.Glu670Ala Single submitter ⚠
- p.Glu670Asp Single submitter ⚠
- p.Glu715Asp Single submitter ⚠
- p.Glu752Asp Single submitter ⚠
- p.Gly35Arg Single submitter ⚠
- p.Gly449Ser Single submitter ⚠
- p.Gly580Arg Single submitter ⚠
- p.Gly580Glu Single submitter ⚠
- p.Gly592Ser Single submitter ⚠
- p.Gly620Ser Single submitter ⚠
- p.Gly63Arg Single submitter ⚠
- p.Gly65Ser Single submitter ⚠
- p.His250Arg Single submitter ⚠
- p.Ile169Val Single submitter ⚠
- p.Ile313Val Single submitter
- p.Ile404Met Single submitter ⚠
- p.Ile439Met Single submitter ⚠
- p.Ile463Thr Single submitter ⚠
- p.Ile666Met Single submitter ⚠
- p.Leu280Phe Single submitter ⚠
- p.Leu447Phe Single submitter ⚠
- p.Leu499Arg Single submitter ⚠
- p.Lys117Asn Single submitter ⚠
- p.Lys200Asn Single submitter ⚠
- p.Met578Ile Single submitter ⚠
- p.Phe50Leu Single submitter ⚠
- p.Pro297Thr Single submitter ⚠
- p.Pro365Gln Single submitter ⚠
- p.Pro365Ser Single submitter ⚠
- p.Pro4Leu Single submitter ⚠
- p.Pro4Ser Single submitter ⚠
- p.Pro69Leu Single submitter ⚠
- p.Ser102Gly Single submitter ⚠
- p.Ser430Pro Single submitter ⚠
- p.Ser464Leu Single submitter ⚠
- p.Ser524Gly Single submitter ⚠
- p.Ser99Thr Single submitter ⚠
- p.Thr434Met Single submitter ⚠
- p.Thr514Ala Single submitter ⚠
- p.Thr717Met Single submitter ⚠
- p.Trp455Arg Single submitter ⚠
- p.Trp455Leu Single submitter ⚠
- p.Trp462Cys Single submitter ⚠
- p.Trp507Cys Single submitter ⚠
- p.Tyr513Cys Single submitter ⚠
- p.Val372Ile Single submitter ⚠
- p.Val448Met Single submitter ⚠
- p.Val758Ile Single submitter ⚠
- p.Val83Gly Single submitter ⚠