TSG101 — 39 ClinVar variants
All ClinVar germline TSG101 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
1 Benign · 38 Uncertain significance
Full TSG101 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TSG101 p.Ala337Thr Uncertain significance Single submitter
- TSG101 p.Asn27Ser Uncertain significance Single submitter
- TSG101 p.Asn83Thr Uncertain significance Single submitter
- TSG101 p.Asp315Asn Uncertain significance Single submitter
- TSG101 p.Gln121Arg Uncertain significance Single submitter
- TSG101 p.Gln203Pro Uncertain significance Single submitter
- TSG101 p.Gly193Ala Uncertain significance Single submitter
- TSG101 p.Gly385Cys Uncertain significance Single submitter
- TSG101 p.His267Asn Uncertain significance Single submitter
- TSG101 p.His267Gln Uncertain significance Single submitter
- TSG101 p.Ile146Val Uncertain significance Single submitter
- TSG101 p.Ile288Leu Uncertain significance Single submitter
- TSG101 p.Lys265Met Uncertain significance Single submitter
- TSG101 p.Lys33Glu Uncertain significance Single submitter
- TSG101 p.Lys382Gln Uncertain significance Single submitter
- TSG101 p.Pro145Ser Uncertain significance Single submitter
- TSG101 p.Pro192Ala Uncertain significance Single submitter
- TSG101 p.Pro208Leu Uncertain significance Single submitter
- TSG101 p.Pro37Arg Uncertain significance Single submitter
- TSG101 p.Ser176Ala Uncertain significance Single submitter
- TSG101 p.Ser176Tyr Uncertain significance Single submitter
- TSG101 p.Ser216Asn Uncertain significance Single submitter
- TSG101 p.Thr156Met Uncertain significance Single submitter
- TSG101 p.Thr21Ala Uncertain significance Single submitter
- TSG101 p.Thr225Ala Uncertain significance Single submitter
- TSG101 p.Val213Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- TSG101 p.Arg241Gln Uncertain significance Single submitter
- TSG101 p.Arg248Cys Uncertain significance Single submitter
- TSG101 p.Arg276His Uncertain significance Single submitter
- TSG101 p.Asp218Val Uncertain significance Single submitter
- TSG101 p.Glu223Lys Uncertain significance Single submitter
- TSG101 p.Glu316Lys Uncertain significance Single submitter
- TSG101 p.Gly177Arg Uncertain significance Single submitter
- TSG101 p.Leu8Phe Uncertain significance Single submitter
- TSG101 p.Lys243Glu Uncertain significance Single submitter
- TSG101 p.Pro151Leu Uncertain significance Single submitter
- TSG101 p.Val353Leu Uncertain significance Single submitter
All TSG101 variants
Benign 1
- p.Ile318= Multiple submitters
Uncertain significance 38
- p.Ala337Thr Single submitter ⚠
- p.Arg241Gln Single submitter ⚠
- p.Arg248Cys Single submitter ⚠
- p.Arg276His Single submitter ⚠
- p.Asn27Ser Single submitter ⚠
- p.Asn83Thr Single submitter ⚠
- p.Asp218Val Single submitter ⚠
- p.Asp315Asn Single submitter ⚠
- p.Gln121Arg Single submitter ⚠
- p.Gln203Pro Single submitter ⚠
- p.Glu223Lys Single submitter ⚠
- p.Glu316Lys Single submitter ⚠
- p.Gly177Arg Single submitter ⚠
- p.Gly193Ala Single submitter ⚠
- p.Gly385Cys Single submitter ⚠
- p.His267Asn Single submitter ⚠
- p.His267Gln Single submitter ⚠
- p.Ile146Val Single submitter ⚠
- p.Ile288Leu Single submitter ⚠
- p.Leu8Phe Single submitter ⚠
- p.Lys243Glu Single submitter ⚠
- p.Lys265Met Single submitter ⚠
- p.Lys33Glu Single submitter ⚠
- p.Lys382Gln Single submitter ⚠
- p.Pro145Ser Single submitter ⚠
- p.Pro151Leu Single submitter ⚠
- p.Pro192Ala Single submitter ⚠
- p.Pro208Leu Single submitter ⚠
- p.Pro37Arg Single submitter ⚠
- p.Ser176Ala Single submitter ⚠
- p.Ser176Tyr Single submitter ⚠
- p.Ser216Asn Single submitter ⚠
- p.Thr156Met Single submitter ⚠
- p.Thr21Ala Single submitter ⚠
- p.Thr225Ala Single submitter ⚠
- p.Tyr390Cys Single submitter
- p.Val213Ile Single submitter ⚠
- p.Val353Leu Single submitter ⚠