TSLP — 25 ClinVar variants
All ClinVar germline TSLP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
2 Likely benign · 23 Uncertain significance
Full TSLP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TSLP p.Arg149His Uncertain significance Single submitter
- TSLP p.Asp35Asn Uncertain significance Single submitter
- TSLP p.Cys137Ser Uncertain significance Single submitter
- TSLP p.Gln140Lys Uncertain significance Single submitter
- TSLP p.Gly24Arg Uncertain significance Single submitter
- TSLP p.Leu7Gln Uncertain significance Single submitter
- TSLP p.Lys157Gln Uncertain significance Single submitter
- TSLP p.Lys95Glu Uncertain significance Single submitter
- TSLP p.Met97Thr Uncertain significance Single submitter
- TSLP p.Thr134Ala Uncertain significance Single submitter
- TSLP p.Thr53Ala Uncertain significance Single submitter
- TSLP p.Thr61Ala Uncertain significance Single submitter
- TSLP p.Thr87Asn Uncertain significance Single submitter
- TSLP p.Tyr113Ser Uncertain significance Single submitter
- TSLP p.Val12Asp Uncertain significance Single submitter
- TSLP p.Val132Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TSLP p.Arg149Cys Uncertain significance Single submitter
- TSLP p.Leu22Pro Uncertain significance Single submitter
- TSLP p.Phe31Val Uncertain significance Single submitter
- TSLP p.Phe36Leu Uncertain significance Single submitter
- TSLP p.Ser68Cys Uncertain significance Single submitter
- TSLP p.Ser92Trp Uncertain significance Single submitter
- TSLP p.Thr32Ile Uncertain significance Single submitter
All TSLP variants
Likely benign 2
- p.Asn152Ser Single submitter
- p.Glu78Lys Single submitter
Uncertain significance 23
- p.Arg149Cys Single submitter ⚠
- p.Arg149His Single submitter ⚠
- p.Asp35Asn Single submitter ⚠
- p.Cys137Ser Single submitter ⚠
- p.Gln140Lys Single submitter ⚠
- p.Gly24Arg Single submitter ⚠
- p.Leu22Pro Single submitter ⚠
- p.Leu7Gln Single submitter ⚠
- p.Lys157Gln Single submitter ⚠
- p.Lys95Glu Single submitter ⚠
- p.Met97Thr Single submitter ⚠
- p.Phe31Val Single submitter ⚠
- p.Phe36Leu Single submitter ⚠
- p.Ser68Cys Single submitter ⚠
- p.Ser92Trp Single submitter ⚠
- p.Thr134Ala Single submitter ⚠
- p.Thr32Ile Single submitter ⚠
- p.Thr53Ala Single submitter ⚠
- p.Thr61Ala Single submitter ⚠
- p.Thr87Asn Single submitter ⚠
- p.Tyr113Ser Single submitter ⚠
- p.Val12Asp Single submitter ⚠
- p.Val132Leu Single submitter ⚠